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3  structures 1  species 0  interactions 1  sequence 1  architecture

Protein: SPD2A_HUMAN (Q5TCZ1)

Summary

This is the summary of UniProt entry SPD2A_HUMAN (Q5TCZ1).

Description: SH3 and PX domain-containing protein 2A
Source organism: Homo sapiens (Human) (NCBI taxonomy ID 9606)
View Pfam proteome data.
Length: 1133 amino acids
Reference Proteome: ✓

Please note: when we start each new Pfam data release, we take a copy of the UniProt sequence database. This snapshot of UniProt forms the basis of the overview that you see here. It is important to note that, although some UniProt entries may be removed after a Pfam release, these entries will not be removed from Pfam until the next Pfam data release.

Pfam domains

Download the data used to generate the domain graphic in JSON format.

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Source Domain Start End
Pfam PX 5 124
disorder n/a 129 135
disorder n/a 155 156
disorder n/a 159 160
Pfam SH3_1 172 217
disorder n/a 217 220
disorder n/a 225 239
low_complexity n/a 241 253
disorder n/a 268 275
Pfam SH3_1 273 317
disorder n/a 320 322
disorder n/a 325 328
disorder n/a 331 332
disorder n/a 351 372
disorder n/a 395 398
disorder n/a 403 407
disorder n/a 410 444
low_complexity n/a 440 451
disorder n/a 449 451
Pfam SH3_1 455 499
disorder n/a 472 474
disorder n/a 497 689
low_complexity n/a 519 537
low_complexity n/a 632 651
low_complexity n/a 654 676
low_complexity n/a 685 714
disorder n/a 705 841
disorder n/a 843 847
Pfam SH3_1 848 891
disorder n/a 862 866
disorder n/a 891 1061
coiled_coil n/a 926 946
disorder n/a 1092 1097

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Sequence information

This is the amino acid sequence of the UniProt sequence database entry with the accession Q5TCZ1. This sequence is stored in the Pfam database and updated with each new Pfam release, but this means that the sequence we store may differ from that stored by UniProt.

Sequence:
1
MLAYCVQDAT VVDVEKRRNP SKHYVYIINV TWSDSTSQTI YRRYSKFFDL
50
51
QMQLLDKFPI EGGQKDPKQR IIPFLPGKIL FRRSHIRDVA VKRLKPIDEY
100
101
CRALVRLPPH ISQCDEVFRF FEARPEDVNP PKEDYGSSKR KSVWLSSWAE
150
151
SPKKDVTGAD ATAEPMILEQ YVVVSNYKKQ ENSELSLQAG EVVDVIEKNE
200
201
SGWWFVSTSE EQGWVPATYL EAQNGTRDDS DINTSKTGEV SKRRKAHLRR
250
251
LDRRWTLGGM VNRQHSREEK YVTVQPYTSQ SKDEIGFEKG VTVEVIRKNL
300
301
EGWWYIRYLG KEGWAPASYL KKAKDDLPTR KKNLAGPVEI IGNIMEISNL
350
351
LNKKASGDKE TPPAEGEGHE APIAKKEISL PILCNASNGS AVGVPDRTVS
400
401
RLAQGSPAVA RIAPQRAQIS SPNLRTRPPP RRESSLGFQL PKPPEPPSVE
450
451
VEYYTIAEFQ SCISDGISFR GGQKAEVIDK NSGGWWYVQI GEKEGWAPAS
500
501
YIDKRKKPNL SRRTSTLTRP KVPPPAPPSK PKEAEEGPTG ASESQDSPRK
550
551
LKYEEPEYDI PAFGFDSEPE LSEEPVEDRA SGERRPAQPH RPSPASSLQR
600
601
ARFKVGESSE DVALEEETIY ENEGFRPYAE DTLSARGSSG DSDSPGSSSL
650
651
SLTRKNSPKS GSPKSSSLLK LKAEKNAQAE MGKNHSSASF SSSITINTTC
700
701
CSSSSSSSSS LSKTSGDLKP RSASDAGIRG TPKVRAKKDA DANAGLTSCP
750
751
RAKPSVRPKP FLNRAESQSQ EKMDISTLRR QLRPTGQLRG GLKGSKSEDS
800
801
ELPPQTASEA PSEGSRRSSS DLITLPATTP PCPTKKEWEG PATSYMTCSA
850
851
YQKVQDSEIS FPAGVEVQVL EKQESGWWYV RFGELEGWAP SHYLVLDENE
900
901
QPDPSGKELD TVPAKGRQNE GKSDSLEKIE RRVQALNTVN QSKKATPPIP
950
951
SKPPGGFGKT SGTPAVKMRN GVRQVAVRPQ SVFVSPPPKD NNLSCALRRN
1000
1001
ESLTATDGLR GVRRNSSFST ARSAAAEAKG RLAERAASQG SDSPLLPAQR
1050
1051
NSIPVSPVRP KPIEKSQFIH NNLKDVYVSI ADYEGDEETA GFQEGVSMEV
1100
1101
LERNPNGWWY CQILDGVKPF KGWVPSNYLE KKN                  
1133
 

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Checksums:
CRC64:D485F49E9192359C
MD5:de932f76d25ce7289c4fd4fdf5c87db7

Structures

For those sequences which have a structure in the Protein DataBank, we use the mapping between UniProt, PDB and Pfam coordinate systems from the PDBe SIFTS project, to allow us to map Pfam domains onto UniProt three-dimensional structures. The table below shows the mapping between Pfam domains, this UniProt entry and a corresponding three dimensional structure.

Pfam family UniProt residues PDB ID PDB chain ID PDB residues View
SH3_1 172 - 217 2EGA A 12 - 57 Jmol OpenAstexViewer
273 - 317 2DNU A 13 - 57 Jmol OpenAstexViewer
848 - 891 2EKH A 14 - 57 Jmol OpenAstexViewer

TreeFam

Below is a phylogenetic tree of animal genes, with ortholog and paralog assignments, from TreeFam.