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0  structures 1  species 0  interactions 1  sequence 1  architecture

Protein: MFS4B_HUMAN (Q5TF39)

Summary

This is the summary of UniProt entry MFS4B_HUMAN (Q5TF39).

Description: Sodium-dependent glucose transporter 1 {ECO:0000250|UniProtKB:Q80T22}
Source organism: Homo sapiens (Human) (NCBI taxonomy ID 9606)
Length: 518 amino acids
Reference Proteome: ✓

Please note: when we start each new Pfam data release, we take a copy of the UniProt sequence database. This snapshot of UniProt forms the basis of the overview that you see here. It is important to note that, although some UniProt entries may be removed after a Pfam release, these entries will not be removed from Pfam until the next Pfam data release.

Pfam domains

Download the data used to generate the domain graphic in JSON format.

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Source Domain Start End
sig_p n/a 1 21
Pfam MFS_1 2 316
transmembrane n/a 31 54
transmembrane n/a 61 79
transmembrane n/a 85 112
transmembrane n/a 124 144
low_complexity n/a 129 148
transmembrane n/a 183 205
transmembrane n/a 226 244
low_complexity n/a 230 240
transmembrane n/a 272 292
transmembrane n/a 299 316
transmembrane n/a 322 344
transmembrane n/a 356 376
transmembrane n/a 388 408
disorder n/a 414 455
low_complexity n/a 435 451
disorder n/a 460 461
disorder n/a 465 474
disorder n/a 476 481
disorder n/a 494 495
disorder n/a 497 518

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Sequence information

This is the amino acid sequence of the UniProt sequence database entry with the accession Q5TF39. This sequence is stored in the Pfam database and updated with each new Pfam release, but this means that the sequence we store may differ from that stored by UniProt.

Sequence:
1
MLCASFLGLG LSVAIVGPTF QDLATNVNRN ISSLSFIFVG RALGYLSGSV
50
51
IGGFLVDVMN YFLLLGISMS ATTVGLYLVP FCKTAILLTV MMSIFGVSIG
100
101
ILDTGGNVLI LAIWGDKGAP HMQALHFSFA LGAFLAPLLA KLALGPTASA
150
151
ENHTESDFHP ALNQSSDADS EALFGVPNDK NLLWAYAVIG TYMFLVSVIF
200
201
FCLFLKNSSK QEKARASAET FRRAKYHNAL LCLLFLFFFF YVGAEVTYGS
250
251
YVFSFATTHA GMKESEAAGL NSIFWGTFAA CRGLAIFFAT CLQPGTMIVL
300
301
SNIGSLTSSL FLVLFDKNPI CLWIATSVYG ASMATTFPSG VSWIEQYTTI
350
351
HGKSAAFFVI GASLGEMAIP AVIGILQGKY PDLPVVLYTS LGASIATGIL
400
401
FPVLYKLATS PLDRQRKEDR KSEDQKALLS SSGLNEYEEE NEEEDAEKWN
450
451
EMDFEMIETN DTMRHSIIET SRSSLTEPTA EVYNQYPSNA LVFESSPFNT
500
501
GSAHVKHLPE TRTKGTNV                                   
518
 

Show the unformatted sequence.

Checksums:
CRC64:FCB02A5E428BD0F5
MD5:dd7c88f2fb72d4591cb57589e5becdb7

TreeFam

Below is a phylogenetic tree of animal genes, with ortholog and paralog assignments, from TreeFam.

AlphaFold Structure Prediction

The protein structure below has been predicted by DeepMind with AlphaFold. For more information, please visit the AlphaFold page for this protein.

Model confidence scale

  Very High (pLDDT > 90)
  Confident (90 > pLDDT > 70)
  Low (70 > pLDDT > 50)
  Very Low (pLDDT < 50)
Highly accurate protein structure prediction with AlphaFold. John Jumper, Richard Evans, Alexander Pritzel, Tim Green, Michael Figurnov, Olaf Ronneberger, Kathryn Tunyasuvunakool, Russ Bates, Augustin Žídek, Anna Potapenko, Alex Bridgland, Clemens Meyer, Simon A. A. Kohl, Andrew J. Ballard, Andrew Cowie, Bernardino Romera-Paredes, Stanislav Nikolov, Rishub Jain, Jonas Adler, Trevor Back, Stig Petersen, David Reiman, Ellen Clancy, Michal Zielinski, Martin Steinegger, Michalina Pacholska, Tamas Berghammer, Sebastian Bodenstein, David Silver, Oriol Vinyals, Andrew W. Senior, Koray Kavukcuoglu, Pushmeet Kohli & Demis Hassabis Nature 2021-07-15; DOI: 10.1038/s41586-021-03819-2;