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0  structures 1  species 0  interactions 1  sequence 1  architecture

Protein: RN220_HUMAN (Q5VTB9)

Summary

This is the summary of UniProt entry RN220_HUMAN (Q5VTB9).

Description: E3 ubiquitin-protein ligase RNF220 EC=2.3.2.27
Source organism: Homo sapiens (Human) (NCBI taxonomy ID 9606)
Length: 566 amino acids
Reference Proteome: ✓

Please note: when we start each new Pfam data release, we take a copy of the UniProt sequence database. This snapshot of UniProt forms the basis of the overview that you see here. It is important to note that, although some UniProt entries may be removed after a Pfam release, these entries will not be removed from Pfam until the next Pfam data release.

Pfam domains

Download the data used to generate the domain graphic in JSON format.

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Source Domain Start End
sig_p n/a 1 34
disorder n/a 38 42
disorder n/a 45 46
disorder n/a 135 141
disorder n/a 147 151
disorder n/a 156 157
disorder n/a 159 161
disorder n/a 164 177
disorder n/a 195 212
Pfam RNF220 217 339
low_complexity n/a 235 250
disorder n/a 237 264
disorder n/a 268 303
disorder n/a 316 347
Pfam RNF220 336 444
disorder n/a 349 350
disorder n/a 356 357
disorder n/a 380 440
low_complexity n/a 389 400
disorder n/a 442 477
coiled_coil n/a 485 505
Pfam zf-C3HC4_2 513 552

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Sequence information

This is the amino acid sequence of the UniProt sequence database entry with the accession Q5VTB9. This sequence is stored in the Pfam database and updated with each new Pfam release, but this means that the sequence we store may differ from that stored by UniProt.

Sequence:
1
MDLHRAAFKM ENSSYLPNPL ASPALMVLAS TAEASRDASI PCQQPRPFGV
50
51
PVSVDKDVHI PFTNGSYTFA SMYHRQGGVP GTFANRDFPP SLLHLHPQFA
100
101
PPNLDCTPIS MLNHSGVGAF RPFASTEDRE SYQSAFTPAK RLKNCHDTES
150
151
PHLRFSDADG KEYDFGTQLP SSSPGSLKVD DTGKKIFAVS GLISDREASS
200
201
SPEDRNDRCK KKAAALFDSQ APICPICQVL LRPSELQEHM EQELEQLAQL
250
251
PSSKNSLLKD AMAPGTPKSL LLSASIKREG ESPTASPHSS ATDDLHHSDR
300
301
YQTFLRVRAN RQTRLNARIG KMKRRKQDEG QREGSCMAED DAVDIEHENN
350
351
NRFEEYEWCG QKRIRATTLL EGGFRGSGFI MCSGKENPDS DADLDVDGDD
400
401
TLEYGKPQYT EADVIPCTGE EPGEAKEREA LRGAVLNGGP PSTRITPEFS
450
451
KWASDEMPST SNGESSKQEA MQKTCKNSDI EKITEDSAVT TFEALKARVR
500
501
ELERQLSRGD RYKCLICMDS YSMPLTSIQC WHVHCEECWL RTLGAKKLCP
550
551
QCNTITAPGD LRRIYL                                     
566
 

Show the unformatted sequence.

Checksums:
CRC64:AAE3C723032B062B
MD5:f60a4eace2e63e1a005d9d62832c54d2

TreeFam

Below is a phylogenetic tree of animal genes, with ortholog and paralog assignments, from TreeFam.

AlphaFold Structure Prediction

The protein structure below has been predicted by DeepMind with AlphaFold. For more information, please visit the AlphaFold page for this protein.

Model confidence scale

  Very High (pLDDT > 90)
  Confident (90 > pLDDT > 70)
  Low (70 > pLDDT > 50)
  Very Low (pLDDT < 50)
Highly accurate protein structure prediction with AlphaFold. John Jumper, Richard Evans, Alexander Pritzel, Tim Green, Michael Figurnov, Olaf Ronneberger, Kathryn Tunyasuvunakool, Russ Bates, Augustin Žídek, Anna Potapenko, Alex Bridgland, Clemens Meyer, Simon A. A. Kohl, Andrew J. Ballard, Andrew Cowie, Bernardino Romera-Paredes, Stanislav Nikolov, Rishub Jain, Jonas Adler, Trevor Back, Stig Petersen, David Reiman, Ellen Clancy, Michal Zielinski, Martin Steinegger, Michalina Pacholska, Tamas Berghammer, Sebastian Bodenstein, David Silver, Oriol Vinyals, Andrew W. Senior, Koray Kavukcuoglu, Pushmeet Kohli & Demis Hassabis Nature 2021-07-15; DOI: 10.1038/s41586-021-03819-2;