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2  structures 1  species 0  interactions 1  sequence 1  architecture

Protein: FBX31_HUMAN (Q5XUX0)

Summary

This is the summary of UniProt entry FBX31_HUMAN (Q5XUX0).

Description: F-box only protein 31
Source organism: Homo sapiens (Human) (NCBI taxonomy ID 9606)
Length: 539 amino acids
Reference Proteome: ✓

Please note: when we start each new Pfam data release, we take a copy of the UniProt sequence database. This snapshot of UniProt forms the basis of the overview that you see here. It is important to note that, although some UniProt entries may be removed after a Pfam release, these entries will not be removed from Pfam until the next Pfam data release.

Pfam domains

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Source Domain Start End
low_complexity n/a 14 24
disorder n/a 18 45
disorder n/a 50 53
low_complexity n/a 51 75
Pfam F-box-like 67 113
disorder n/a 231 238
disorder n/a 241 242
Pfam Cyclin_D1_bind 286 515
disorder n/a 301 303
disorder n/a 327 357
coiled_coil n/a 363 383
disorder n/a 368 440
low_complexity n/a 370 383
low_complexity n/a 378 396
low_complexity n/a 415 435
disorder n/a 442 447
disorder n/a 449 452

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Sequence information

This is the amino acid sequence of the UniProt sequence database entry with the accession Q5XUX0. This sequence is stored in the Pfam database and updated with each new Pfam release, but this means that the sequence we store may differ from that stored by UniProt.

Sequence:
1
MAVCARLCGV GPSRGCRRRQ QRRGPAETAA ADSEPDTDPE EERIEASAGV
50
51
GGGLCAGPSP PPPRCSLLEL PPELLVEIFA SLPGTDLPSL AQVCTKFRRI
100
101
LHTDTIWRRR CREEYGVCEN LRKLEITGVS CRDVYAKLLH RYRHILGLWQ
150
151
PDIGPYGGLL NVVVDGLFII GWMYLPPHDP HVDDPMRFKP LFRIHLMERK
200
201
AATVECMYGH KGPHHGHIQI VKKDEFSTKC NQTDHHRMSG GRQEEFRTWL
250
251
REEWGRTLED IFHEHMQELI LMKFIYTSQY DNCLTYRRIY LPPSRPDDLI
300
301
KPGLFKGTYG SHGLEIVMLS FHGRRARGTK ITGDPNIPAG QQTVEIDLRH
350
351
RIQLPDLENQ RNFNELSRIV LEVRERVRQE QQEGGHEAGE GRGRQGPRES
400
401
QPSPAQPRAE APSKGPDGTP GEDGGEPGDA VAAAEQPAQC GQGQPFVLPV
450
451
GVSSRNEDYP RTCRMCFYGT GLIAGHGFTS PERTPGVFIL FDEDRFGFVW
500
501
LELKSFSLYS RVQATFRNAD APSPQAFDEM LKNIQSLTS            
539
 

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Checksums:
CRC64:E833D63A361E7381
MD5:79bdee26b7b9e99ebd6016d95de2a6cd

Structures

For those sequences which have a structure in the Protein DataBank, we use the mapping between UniProt, PDB and Pfam coordinate systems from the PDBe SIFTS project, to allow us to map Pfam domains onto UniProt three-dimensional structures. The table below shows the mapping between Pfam domains, this UniProt entry and a corresponding three dimensional structure.

Pfam family UniProt residues PDB ID PDB chain ID PDB residues View
Cyclin_D1_bind 286 - 515 5VZT B 286 - 515 Show 3D Structure View in InterPro
D 286 - 515 Show 3D Structure View in InterPro
5VZU B 286 - 515 Show 3D Structure View in InterPro
D 286 - 515 Show 3D Structure View in InterPro
F-box-like 67 - 113 5VZT B 67 - 113 Show 3D Structure View in InterPro
D 67 - 113 Show 3D Structure View in InterPro
5VZU B 67 - 113 Show 3D Structure View in InterPro
D 67 - 113 Show 3D Structure View in InterPro
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The parts of the structure corresponding to the Pfam family are highlighted in blue.

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TreeFam

Below is a phylogenetic tree of animal genes, with ortholog and paralog assignments, from TreeFam.

AlphaFold Structure Prediction

The protein structure below has been predicted by DeepMind with AlphaFold. For more information, please visit the AlphaFold page for this protein.

Model confidence scale

  Very High (pLDDT > 90)
  Confident (90 > pLDDT > 70)
  Low (70 > pLDDT > 50)
  Very Low (pLDDT < 50)
Highly accurate protein structure prediction with AlphaFold. John Jumper, Richard Evans, Alexander Pritzel, Tim Green, Michael Figurnov, Olaf Ronneberger, Kathryn Tunyasuvunakool, Russ Bates, Augustin Žídek, Anna Potapenko, Alex Bridgland, Clemens Meyer, Simon A. A. Kohl, Andrew J. Ballard, Andrew Cowie, Bernardino Romera-Paredes, Stanislav Nikolov, Rishub Jain, Jonas Adler, Trevor Back, Stig Petersen, David Reiman, Ellen Clancy, Michal Zielinski, Martin Steinegger, Michalina Pacholska, Tamas Berghammer, Sebastian Bodenstein, David Silver, Oriol Vinyals, Andrew W. Senior, Koray Kavukcuoglu, Pushmeet Kohli & Demis Hassabis Nature 2021-07-15; DOI: 10.1038/s41586-021-03819-2;