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6  structures 1  species 0  interactions 1  sequence 1  architecture

Protein: SIN3B_MOUSE (Q62141)

Summary

This is the summary of UniProt entry SIN3B_MOUSE (Q62141).

Description: Paired amphipathic helix protein Sin3b
Source organism: Mus musculus (Mouse) (NCBI taxonomy ID 10090)
Length: 1098 amino acids
Reference Proteome: ✓

Please note: when we start each new Pfam data release, we take a copy of the UniProt sequence database. This snapshot of UniProt forms the basis of the overview that you see here. It is important to note that, although some UniProt entries may be removed after a Pfam release, these entries will not be removed from Pfam until the next Pfam data release.

Pfam domains

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Source Domain Start End
disorder n/a 1 2
low_complexity n/a 5 26
disorder n/a 12 22
disorder n/a 25 26
Pfam PAH 53 97
disorder n/a 112 126
disorder n/a 128 135
Pfam PAH 173 227
disorder n/a 192 194
disorder n/a 196 198
disorder n/a 238 242
disorder n/a 245 262
disorder n/a 264 267
Pfam PAH 313 357
Pfam Sin3_corepress 386 481
disorder n/a 589 608
disorder n/a 664 701
low_complexity n/a 667 688
Pfam Sin3a_C 712 1011
coiled_coil n/a 729 756
low_complexity n/a 740 762
disorder n/a 755 759
disorder n/a 767 772
low_complexity n/a 933 944

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Sequence information

This is the amino acid sequence of the UniProt sequence database entry with the accession Q62141. This sequence is stored in the Pfam database and updated with each new Pfam release, but this means that the sequence we store may differ from that stored by UniProt.

Sequence:
1
MAHAGSGGSA GRGFGGSRWG RSGSGGHEKL PVHVEDALTY LDQVKIRFGS
50
51
DPATYNGFLE IMKEFKSQSI DTPGVIRRVS QLFHEHPDLI VGFNAFLPLG
100
101
YRIDIPKNGK LNIQSPLSSQ DNSHSHGDCG EDFKQMSYKE DRGQVPLESD
150
151
SVEFNNAISY VNKIKTRFLD HPEIYRSFLE ILHTYQKEQL HTKGRPFRGM
200
201
SEEEVFTEVA NLFRGQEDLL SEFGQFLPEA KRSLFTGNGS CEMNSGQKNE
250
251
EKSLEHNKKR SRPSLLRPVS APAKKKMKLR GTKDLSIAAV GKYGTLQEFS
300
301
FFDKVRRVLK SQEVYENFLR CIALFNQELV SGSELLQLVS PFLGKFPELF
350
351
AQFKSFLGVK ELSFAPPMSD RSGDGISREI DYASCKRIGS SYRALPKTYQ
400
401
QPKCSGRTAI CKEVLNDTWV SFPSWSEDST FVSSKKTPYE EQLHRCEDER
450
451
FELDVVLETN LATIRVLESV QKKLSRMAPE DQEKLRLDDC LGGTSEVIQR
500
501
RAIHRIYGDK APEVIESLKR NPATAVPVVL KRLKAKEEEW REAQQGFNKI
550
551
WREQYEKAYL KSLDHQAVNF KQNDTKALRS KSLLNEIESV YDEHQEQHSE
600
601
GRSAPSSEPH LIFVYEDRQI LEDAAALISY YVKRQPAIQK EDQGTIRQLL
650
651
HRFLPSLFFS QQCPGTSDDS ADERDRDRDS AEPERRRPTD EKPPADASPE
700
701
PPKVLDDVYS LFFANNNWYF FLRLHQTLCA RLLKIYRQAQ KQLLEHRREQ
750
751
EREQLLCEGR REKAADPAME LRLKQPSEVE LEEYYPAFLD MVRSLLEGSI
800
801
DPTQYEDTLR EMFTIHAYIG FTMDKLVQNI ARQLHHLVSD DVCLKVVELY
850
851
LNEQQRGAAG GNLSSRCVRA ARETSYQWKA ERCMADENCF KVMFLQRRGQ
900
901
VIMTIELLDT EEAQTEDPVE VQHLARYVEQ YVGSEGASSS STEGFLLKPV
950
951
FLQRNLKKFR RWQCEQVRAM RGEAKSSWKR LMGVESACDV DCRFRLGTHK
1000
1001
MVFIVNSEDY MYRRGTLCRA KQVQPLVLLR HHRHFEEWHG RWLEDNVTVA
1050
1051
AAGLVQDWLM GEEEEDMVPC KTLCETAHVH GLPVTRYRVQ YSRRPASP  
1098
 

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Checksums:
CRC64:A73F6DFC11EBA256
MD5:22898f6d920ace30f8553c76e2603979

Structures

For those sequences which have a structure in the Protein DataBank, we use the mapping between UniProt, PDB and Pfam coordinate systems from the PDBe SIFTS project, to allow us to map Pfam domains onto UniProt three-dimensional structures. The table below shows the mapping between Pfam domains, this UniProt entry and a corresponding three dimensional structure.

Pfam family UniProt residues PDB ID PDB chain ID PDB residues View
PAH 173 - 227 1E91 A 26 - 80 Show 3D Structure View in InterPro
1PD7 A 26 - 80 Show 3D Structure View in InterPro
2F05 A 26 - 80 Show 3D Structure View in InterPro
53 - 97 2CR7 A 29 - 73 Show 3D Structure View in InterPro
2CZY A 53 - 97 Show 3D Structure View in InterPro
5Y95 A 53 - 97 Show 3D Structure View in InterPro
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The parts of the structure corresponding to the Pfam family are highlighted in blue.

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TreeFam

Below is a phylogenetic tree of animal genes, with ortholog and paralog assignments, from TreeFam.

AlphaFold Structure Prediction

The protein structure below has been predicted by DeepMind with AlphaFold. For more information, please visit the AlphaFold page for this protein.

Model confidence scale

  Very High (pLDDT > 90)
  Confident (90 > pLDDT > 70)
  Low (70 > pLDDT > 50)
  Very Low (pLDDT < 50)
Highly accurate protein structure prediction with AlphaFold. John Jumper, Richard Evans, Alexander Pritzel, Tim Green, Michael Figurnov, Olaf Ronneberger, Kathryn Tunyasuvunakool, Russ Bates, Augustin Žídek, Anna Potapenko, Alex Bridgland, Clemens Meyer, Simon A. A. Kohl, Andrew J. Ballard, Andrew Cowie, Bernardino Romera-Paredes, Stanislav Nikolov, Rishub Jain, Jonas Adler, Trevor Back, Stig Petersen, David Reiman, Ellen Clancy, Michal Zielinski, Martin Steinegger, Michalina Pacholska, Tamas Berghammer, Sebastian Bodenstein, David Silver, Oriol Vinyals, Andrew W. Senior, Koray Kavukcuoglu, Pushmeet Kohli & Demis Hassabis Nature 2021-07-15; DOI: 10.1038/s41586-021-03819-2;