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0  structures 1  species 0  interactions 1  sequence 1  architecture

Protein: FMN1_HUMAN (Q68DA7)

Summary

This is the summary of UniProt entry FMN1_HUMAN (Q68DA7).

Description: Formin-1
Source organism: Homo sapiens (Human) (NCBI taxonomy ID 9606)
Length: 1419 amino acids
Reference Proteome: ✓

Please note: when we start each new Pfam data release, we take a copy of the UniProt sequence database. This snapshot of UniProt forms the basis of the overview that you see here. It is important to note that, although some UniProt entries may be removed after a Pfam release, these entries will not be removed from Pfam until the next Pfam data release.

Pfam domains

Download the data used to generate the domain graphic in JSON format.

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Source Domain Start End
disorder n/a 61 63
disorder n/a 70 75
low_complexity n/a 84 102
disorder n/a 119 121
disorder n/a 143 200
low_complexity n/a 175 185
disorder n/a 207 216
disorder n/a 223 255
disorder n/a 258 259
disorder n/a 261 413
disorder n/a 417 418
disorder n/a 420 556
low_complexity n/a 489 499
low_complexity n/a 518 531
disorder n/a 562 650
disorder n/a 663 666
disorder n/a 673 715
coiled_coil n/a 723 743
disorder n/a 760 765
disorder n/a 773 775
disorder n/a 799 801
disorder n/a 811 978
low_complexity n/a 867 958
Pfam FH2 972 1363
disorder n/a 987 992
disorder n/a 994 995
disorder n/a 997 1010
disorder n/a 1015 1026
disorder n/a 1029 1036
low_complexity n/a 1040 1049
low_complexity n/a 1114 1123
coiled_coil n/a 1263 1290
coiled_coil n/a 1307 1327
disorder n/a 1318 1322
disorder n/a 1390 1393
disorder n/a 1396 1397
disorder n/a 1399 1419

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Sequence information

This is the amino acid sequence of the UniProt sequence database entry with the accession Q68DA7. This sequence is stored in the Pfam database and updated with each new Pfam release, but this means that the sequence we store may differ from that stored by UniProt.

Sequence:
1
MEGTHCTLQL HKPITELCYI SFCLPKGEVR GFSYKGTVTL DRSNKGFHNC
50
51
YQVREESDII SLSQEPDEHP GDIFFKQTPT KDILTELYKL TTERERLLTN
100
101
LLSSDHILGI TMGNQEGKLQ ELSVSLAPED DCFQSAGDWQ GELPVGPLNK
150
151
RSTHGNKKPR RSSGRRESFG ALPQKRTKRK GRGGRESAPL MGKDKICSSH
200
201
SLPLSRTRPN LWVLEEKGNL LPNGALACSL QRRESCPPDI PKTPDTDLGF
250
251
GSFETAFKDT GLGREVLPPD CSSTEAGGDG IRRPPSGLEH QQTGLSESHQ
300
301
DPEKHPEAEK DEMEKPAKRT CKQKPVSKVV AKVQDLSSQV QRVVKTHSKG
350
351
KETIAIRPAA HAEFVPKADL LTLPGAEAGA HGSRRQGKER QGDRSSQSPA
400
401
GETASISSVS ASAEGAVNKV PLKVIESEKL DEAPEGKRLG FPVHTSVPHT
450
451
RPETRNKRRA GLPLGGHKSL FLDLPHKVGP DSSQPRGDKK KPSPPAPAAL
500
501
GKVFNNSASQ SSTHKQTSPV PSPLSPRLPS PQQHHRILRL PALPGEREAA
550
551
LNDSPCRKSR VFSGCVSADT LEPPSSAKVT ETKGASPAFL RAGQPRLVPG
600
601
ETLEKSLGPG KTTAEPQHQS PPGISSEGFP WDGFNEQTPK DLPNRDGGAW
650
651
VLGYRAGPAC PFLLHEEREK SNRSELYLDL HPDHSLTEQD DRTPGRLQAV
700
701
WPPPKTKDTE EKVGLKYTEA EYQAAILHLK REHKEEIENL QAQFELRAFH
750
751
IRGEHAMITA RLEETIENLK HELEHRWRGG CEERKDVCIS TDDDCPPKTF
800
801
RNVCVQTDRE TFLKPCESES KTTRSNQLVP KKLNISSLSQ LSPPNDHKDI
850
851
HAALQPMEGM ASNQQKALPP PPASIPPPPP LPSGLGSLSP APPMPPVSAG
900
901
PPLPPPPPPP PPLPPPSSAG PPPPPPPPPL PNSPAPPNPG GPPPAPPPPG
950
951
LAPPPPPGLF FGLGSSSSQC PRKPAIEPSC PMKPLYWTRI QISDRSQNAT
1000
1001
PTLWDSLEEP DIRDPSEFEY LFSKDTTQQK KKPLSETYEK KNKVKKIIKL
1050
1051
LDGKRSQTVG ILISSLHLEM KDIQQAIFNV DDSVVDLETL AALYENRAQE
1100
1101
DELVKIRKYY ETSKEEELKL LDKPEQFLHE LAQIPNFAER AQCIIFRSVF
1150
1151
SEGITSLHRK VEIITRASKD LLHVKSVKDI LALILAFGNY MNGGNRTRGQ
1200
1201
ADGYSLEILP KLKDVKSRDN GINLVDYVVK YYLRYYDQEA GTEKSVFPLP
1250
1251
EPQDFFLASQ VKFEDLIKDL RKLKRQLEAS EKQMVVVCKE SPKEYLQPFK
1300
1301
DKLEEFFQKA KKEHKMEESH LENAQKSFET TVRYFGMKPK SGEKEITPSY
1350
1351
VFMVWYEFCS DFKTIWKRES KNISKERLKM AQESVSKLTS EKKVETKKIN
1400
1401
PTASLKERLR QKEASVTTN                                  
1419
 

Show the unformatted sequence.

Checksums:
CRC64:6ED2783FC8151A43
MD5:130257b56a9be7f69ac10fb5106ae0b7

TreeFam

Below is a phylogenetic tree of animal genes, with ortholog and paralog assignments, from TreeFam.

AlphaFold Structure Prediction

The protein structure below has been predicted by DeepMind with AlphaFold. For more information, please visit the AlphaFold page for this protein.

Model confidence scale

  Very High (pLDDT > 90)
  Confident (90 > pLDDT > 70)
  Low (70 > pLDDT > 50)
  Very Low (pLDDT < 50)
Highly accurate protein structure prediction with AlphaFold. John Jumper, Richard Evans, Alexander Pritzel, Tim Green, Michael Figurnov, Olaf Ronneberger, Kathryn Tunyasuvunakool, Russ Bates, Augustin Žídek, Anna Potapenko, Alex Bridgland, Clemens Meyer, Simon A. A. Kohl, Andrew J. Ballard, Andrew Cowie, Bernardino Romera-Paredes, Stanislav Nikolov, Rishub Jain, Jonas Adler, Trevor Back, Stig Petersen, David Reiman, Ellen Clancy, Michal Zielinski, Martin Steinegger, Michalina Pacholska, Tamas Berghammer, Sebastian Bodenstein, David Silver, Oriol Vinyals, Andrew W. Senior, Koray Kavukcuoglu, Pushmeet Kohli & Demis Hassabis Nature 2021-07-15; DOI: 10.1038/s41586-021-03819-2;