Please note: this site relies heavily on the use of javascript. Without a javascript-enabled browser, this site will not function correctly. Please enable javascript and reload the page, or switch to a different browser.
1  structure 1  species 0  interactions 1  sequence 1  architecture

Protein: SDE2_HUMAN (Q6IQ49)

Summary

This is the summary of UniProt entry SDE2_HUMAN (Q6IQ49).

Description: Replication stress response regulator SDE2 {ECO:0000305}
Source organism: Homo sapiens (Human) (NCBI taxonomy ID 9606)
Length: 451 amino acids
Reference Proteome: ✓

Please note: when we start each new Pfam data release, we take a copy of the UniProt sequence database. This snapshot of UniProt forms the basis of the overview that you see here. It is important to note that, although some UniProt entries may be removed after a Pfam release, these entries will not be removed from Pfam until the next Pfam data release.

Pfam domains

Download the data used to generate the domain graphic in JSON format.

Show or hide the data used to generate the graphic in JSON format.

Source Domain Start End
Pfam Sde2_N_Ubi 42 166
disorder n/a 103 106
coiled_coil n/a 109 143
disorder n/a 115 139
low_complexity n/a 123 140
disorder n/a 143 144
disorder n/a 155 159
disorder n/a 162 203
disorder n/a 206 208
disorder n/a 218 373
low_complexity n/a 226 242
low_complexity n/a 314 328
low_complexity n/a 352 368
Pfam SDE2_2C 356 444
low_complexity n/a 395 408

Show or hide domain scores.

Sequence information

This is the amino acid sequence of the UniProt sequence database entry with the accession Q6IQ49. This sequence is stored in the Pfam database and updated with each new Pfam release, but this means that the sequence we store may differ from that stored by UniProt.

Sequence:
1
MAEAAALVWI RGPGFGCKAV RCASGRCTVR DFIHRHCQDQ NVPVENFFVK
50
51
CNGALINTSD TVQHGAVYSL EPRLCGGKGG FGSMLRALGA QIEKTTNREA
100
101
CRDLSGRRLR DVNHEKAMAE WVKQQAEREA EKEQKRLERL QRKLVEPKHC
150
151
FTSPDYQQQC HEMAERLEDS VLKGMQAASS KMVSAEISEN RKRQWPTKSQ
200
201
TDRGASAGKR RCFWLGMEGL ETAEGSNSES SDDDSEEAPS TSGMGFHAPK
250
251
IGSNGVEMAA KFPSGSQRAR VVNTDHGSPE QLQIPVTDSG RHILEDSCAE
300
301
LGESKEHMES RMVTETEETQ EKKAESKEPI EEEPTGAGLN KDKETEERTD
350
351
GERVAEVAPE ERENVAVAKL QESQPGNAVI DKETIDLLAF TSVAELELLG
400
401
LEKLKCELMA LGLKCGGTLQ ERAARLFSVR GLAKEQIDPA LFAKPLKGKK
450
451
K                                                     
451
 

Show the unformatted sequence.

Checksums:
CRC64:D7C19152E0051A21
MD5:68afa621a5804352ec05bfca9f73ec0f

Structures

For those sequences which have a structure in the Protein DataBank, we use the mapping between UniProt, PDB and Pfam coordinate systems from the PDBe SIFTS project, to allow us to map Pfam domains onto UniProt three-dimensional structures. The table below shows the mapping between Pfam domains, this UniProt entry and a corresponding three dimensional structure.

Pfam family UniProt residues PDB ID PDB chain ID PDB residues View
Sde2_N_Ubi 93 - 126 6QDV z 93 - 126 Show 3D Structure View in InterPro
×

The parts of the structure corresponding to the Pfam family are highlighted in blue.

Loading Structure Data

TreeFam

Below is a phylogenetic tree of animal genes, with ortholog and paralog assignments, from TreeFam.

AlphaFold Structure Prediction

The protein structure below has been predicted by DeepMind with AlphaFold. For more information, please visit the AlphaFold page for this protein.

Model confidence scale

  Very High (pLDDT > 90)
  Confident (90 > pLDDT > 70)
  Low (70 > pLDDT > 50)
  Very Low (pLDDT < 50)
Highly accurate protein structure prediction with AlphaFold. John Jumper, Richard Evans, Alexander Pritzel, Tim Green, Michael Figurnov, Olaf Ronneberger, Kathryn Tunyasuvunakool, Russ Bates, Augustin Žídek, Anna Potapenko, Alex Bridgland, Clemens Meyer, Simon A. A. Kohl, Andrew J. Ballard, Andrew Cowie, Bernardino Romera-Paredes, Stanislav Nikolov, Rishub Jain, Jonas Adler, Trevor Back, Stig Petersen, David Reiman, Ellen Clancy, Michal Zielinski, Martin Steinegger, Michalina Pacholska, Tamas Berghammer, Sebastian Bodenstein, David Silver, Oriol Vinyals, Andrew W. Senior, Koray Kavukcuoglu, Pushmeet Kohli & Demis Hassabis Nature 2021-07-15; DOI: 10.1038/s41586-021-03819-2;