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3  structures 1  species 0  interactions 1  sequence 1  architecture

Protein: TET2_HUMAN (Q6N021)

Summary

This is the summary of UniProt entry TET2_HUMAN (Q6N021).

Description: Methylcytosine dioxygenase TET2
Source organism: Homo sapiens (Human) (NCBI taxonomy ID 9606)
Length: 2002 amino acids
Reference Proteome: ✓

Please note: when we start each new Pfam data release, we take a copy of the UniProt sequence database. This snapshot of UniProt forms the basis of the overview that you see here. It is important to note that, although some UniProt entries may be removed after a Pfam release, these entries will not be removed from Pfam until the next Pfam data release.

Pfam domains

Download the data used to generate the domain graphic in JSON format.

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Source Domain Start End
disorder n/a 1 18
disorder n/a 20 22
disorder n/a 25 26
disorder n/a 28 53
disorder n/a 69 86
disorder n/a 89 94
disorder n/a 99 100
disorder n/a 105 154
low_complexity n/a 105 116
disorder n/a 164 187
disorder n/a 192 194
disorder n/a 209 222
disorder n/a 224 225
disorder n/a 258 296
disorder n/a 326 334
disorder n/a 339 375
disorder n/a 382 383
disorder n/a 387 560
low_complexity n/a 397 419
disorder n/a 563 567
disorder n/a 570 671
disorder n/a 673 779
low_complexity n/a 730 755
disorder n/a 787 822
disorder n/a 839 861
disorder n/a 863 870
disorder n/a 878 884
disorder n/a 890 1023
low_complexity n/a 908 916
low_complexity n/a 957 970
disorder n/a 1025 1029
disorder n/a 1050 1053
disorder n/a 1057 1099
Pfam Tet_JBP 1290 1905
disorder n/a 1323 1325
disorder n/a 1392 1394
disorder n/a 1399 1403
disorder n/a 1405 1411
disorder n/a 1431 1435
disorder n/a 1437 1438
disorder n/a 1440 1445
disorder n/a 1461 1597
low_complexity n/a 1467 1482
coiled_coil n/a 1472 1492
low_complexity n/a 1473 1494
low_complexity n/a 1522 1552
disorder n/a 1599 1627
disorder n/a 1629 1630
disorder n/a 1644 1646
disorder n/a 1653 1665
disorder n/a 1670 1672
disorder n/a 1705 1709
disorder n/a 1717 1765
disorder n/a 1777 1778
disorder n/a 1783 1799
disorder n/a 1801 1804
disorder n/a 1812 1852
disorder n/a 1857 1860
disorder n/a 1878 1879
disorder n/a 1881 1903
disorder n/a 1912 1920
low_complexity n/a 1917 1933
disorder n/a 1922 1923
disorder n/a 1926 1966
low_complexity n/a 1974 1986
disorder n/a 1976 1986
disorder n/a 1988 1989

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Sequence information

This is the amino acid sequence of the UniProt sequence database entry with the accession Q6N021. This sequence is stored in the Pfam database and updated with each new Pfam release, but this means that the sequence we store may differ from that stored by UniProt.

Sequence:
1
MEQDRTNHVE GNRLSPFLIP SPPICQTEPL ATKLQNGSPL PERAHPEVNG
50
51
DTKWHSFKSY YGIPCMKGSQ NSRVSPDFTQ ESRGYSKCLQ NGGIKRTVSE
100
101
PSLSGLLQIK KLKQDQKANG ERRNFGVSQE RNPGESSQPN VSDLSDKKES
150
151
VSSVAQENAV KDFTSFSTHN CSGPENPELQ ILNEQEGKSA NYHDKNIVLL
200
201
KNKAVLMPNG ATVSASSVEH THGELLEKTL SQYYPDCVSI AVQKTTSHIN
250
251
AINSQATNEL SCEITHPSHT SGQINSAQTS NSELPPKPAA VVSEACDADD
300
301
ADNASKLAAM LNTCSFQKPE QLQQQKSVFE ICPSPAENNI QGTTKLASGE
350
351
EFCSGSSSNL QAPGGSSERY LKQNEMNGAY FKQSSVFTKD SFSATTTPPP
400
401
PSQLLLSPPP PLPQVPQLPS EGKSTLNGGV LEEHHHYPNQ SNTTLLREVK
450
451
IEGKPEAPPS QSPNPSTHVC SPSPMLSERP QNNCVNRNDI QTAGTMTVPL
500
501
CSEKTRPMSE HLKHNPPIFG SSGELQDNCQ QLMRNKEQEI LKGRDKEQTR
550
551
DLVPPTQHYL KPGWIELKAP RFHQAESHLK RNEASLPSIL QYQPNLSNQM
600
601
TSKQYTGNSN MPGGLPRQAY TQKTTQLEHK SQMYQVEMNQ GQSQGTVDQH
650
651
LQFQKPSHQV HFSKTDHLPK AHVQSLCGTR FHFQQRADSQ TEKLMSPVLK
700
701
QHLNQQASET EPFSNSHLLQ HKPHKQAAQT QPSQSSHLPQ NQQQQQKLQI
750
751
KNKEEILQTF PHPQSNNDQQ REGSFFGQTK VEECFHGENQ YSKSSEFETH
800
801
NVQMGLEEVQ NINRRNSPYS QTMKSSACKI QVSCSNNTHL VSENKEQTTH
850
851
PELFAGNKTQ NLHHMQYFPN NVIPKQDLLH RCFQEQEQKS QQASVLQGYK
900
901
NRNQDMSGQQ AAQLAQQRYL IHNHANVFPV PDQGGSHTQT PPQKDTQKHA
950
951
ALRWHLLQKQ EQQQTQQPQT ESCHSQMHRP IKVEPGCKPH ACMHTAPPEN
1000
1001
KTWKKVTKQE NPPASCDNVQ QKSIIETMEQ HLKQFHAKSL FDHKALTLKS
1050
1051
QKQVKVEMSG PVTVLTRQTT AAELDSHTPA LEQQTTSSEK TPTKRTAASV
1100
1101
LNNFIESPSK LLDTPIKNLL DTPVKTQYDF PSCRCVEQII EKDEGPFYTH
1150
1151
LGAGPNVAAI REIMEERFGQ KGKAIRIERV IYTGKEGKSS QGCPIAKWVV
1200
1201
RRSSSEEKLL CLVRERAGHT CEAAVIVILI LVWEGIPLSL ADKLYSELTE
1250
1251
TLRKYGTLTN RRCALNEERT CACQGLDPET CGASFSFGCS WSMYYNGCKF
1300
1301
ARSKIPRKFK LLGDDPKEEE KLESHLQNLS TLMAPTYKKL APDAYNNQIE
1350
1351
YEHRAPECRL GLKEGRPFSG VTACLDFCAH AHRDLHNMQN GSTLVCTLTR
1400
1401
EDNREFGGKP EDEQLHVLPL YKVSDVDEFG SVEAQEEKKR SGAIQVLSSF
1450
1451
RRKVRMLAEP VKTCRQRKLE AKKAAAEKLS SLENSSNKNE KEKSAPSRTK
1500
1501
QTENASQAKQ LAELLRLSGP VMQQSQQPQP LQKQPPQPQQ QQRPQQQQPH
1550
1551
HPQTESVNSY SASGSTNPYM RRPNPVSPYP NSSHTSDIYG STSPMNFYST
1600
1601
SSQAAGSYLN SSNPMNPYPG LLNQNTQYPS YQCNGNLSVD NCSPYLGSYS
1650
1651
PQSQPMDLYR YPSQDPLSKL SLPPIHTLYQ PRFGNSQSFT SKYLGYGNQN
1700
1701
MQGDGFSSCT IRPNVHHVGK LPPYPTHEMD GHFMGATSRL PPNLSNPNMD
1750
1751
YKNGEHHSPS HIIHNYSAAP GMFNSSLHAL HLQNKENDML SHTANGLSKM
1800
1801
LPALNHDRTA CVQGGLHKLS DANGQEKQPL ALVQGVASGA EDNDEVWSDS
1850
1851
EQSFLDPDIG GVAVAPTHGS ILIECAKREL HATTPLKNPN RNHPTRISLV
1900
1901
FYQHKSMNEP KHGLALWEAK MAEKAREKEE ECEKYGPDYV PQKSHGKKVK
1950
1951
REPAEPHETS EPTYLRFIKS LAERTMSVTT DSTVTTSPYA FTRVTGPYNR
2000
2001
YI                                                    
2002
 

Show the unformatted sequence.

Checksums:
CRC64:6D740305EE2A8D46
MD5:12935e5a6d3fa2ebe364401286e21b49

Structures

For those sequences which have a structure in the Protein DataBank, we use the mapping between UniProt, PDB and Pfam coordinate systems from the PDBe SIFTS project, to allow us to map Pfam domains onto UniProt three-dimensional structures. The table below shows the mapping between Pfam domains, this UniProt entry and a corresponding three dimensional structure.

Pfam family UniProt residues PDB ID PDB chain ID PDB residues View
Tet_JBP 1290 - 1905 4NM6 A 1290 - 1905 Jmol OpenAstexViewer
5D9Y A 1290 - 1905 Jmol OpenAstexViewer
5DEU A 1290 - 1905 Jmol OpenAstexViewer

TreeFam

Below is a phylogenetic tree of animal genes, with ortholog and paralog assignments, from TreeFam.