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19  structures 1  species 0  interactions 1  sequence 1  architecture

Protein: PRP8_HUMAN (Q6P2Q9)

Summary

This is the summary of UniProt entry PRP8_HUMAN (Q6P2Q9).

Description: Pre-mRNA-processing-splicing factor 8
Source organism: Homo sapiens (Human) (NCBI taxonomy ID 9606)
View Pfam proteome data.
Length: 2335 amino acids
Reference Proteome: ✓

Please note: when we start each new Pfam data release, we take a copy of the UniProt sequence database. This snapshot of UniProt forms the basis of the overview that you see here. It is important to note that, although some UniProt entries may be removed after a Pfam release, these entries will not be removed from Pfam until the next Pfam data release.

Pfam domains

Download the data used to generate the domain graphic in JSON format.

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Source Domain Start End
disorder n/a 16 25
Pfam PRO8NT 58 209
disorder n/a 64 69
disorder n/a 72 73
low_complexity n/a 149 165
low_complexity n/a 165 174
disorder n/a 363 364
disorder n/a 366 368
low_complexity n/a 368 387
disorder n/a 370 371
Pfam PROCN 395 801
low_complexity n/a 801 813
Pfam RRM_4 986 1077
low_complexity n/a 989 998
Pfam U5_2-snRNA_bdg 1210 1343
Pfam U6-snRNA_bdg 1442 1600
Pfam PRP8_domainIV 1760 1989
disorder n/a 2023 2035
disorder n/a 2037 2055
disorder n/a 2058 2061
Pfam JAB 2099 2205
disorder n/a 2180 2194
disorder n/a 2199 2200
Pfam PROCT 2212 2333
disorder n/a 2236 2244
disorder n/a 2246 2251

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Sequence information

This is the amino acid sequence of the UniProt sequence database entry with the accession Q6P2Q9. This sequence is stored in the Pfam database and updated with each new Pfam release, but this means that the sequence we store may differ from that stored by UniProt.

Sequence:
1
MAGVFPYRGP GNPVPGPLAP LPDYMSEEKL QEKARKWQQL QAKRYAEKRK
50
51
FGFVDAQKED MPPEHVRKII RDHGDMTNRK FRHDKRVYLG ALKYMPHAVL
100
101
KLLENMPMPW EQIRDVPVLY HITGAISFVN EIPWVIEPVY ISQWGSMWIM
150
151
MRREKRDRRH FKRMRFPPFD DEEPPLDYAD NILDVEPLEA IQLELDPEED
200
201
APVLDWFYDH QPLRDSRKYV NGSTYQRWQF TLPMMSTLYR LANQLLTDLV
250
251
DDNYFYLFDL KAFFTSKALN MAIPGGPKFE PLVRDINLQD EDWNEFNDIN
300
301
KIIIRQPIRT EYKIAFPYLY NNLPHHVHLT WYHTPNVVFI KTEDPDLPAF
350
351
YFDPLINPIS HRHSVKSQEP LPDDDEEFEL PEFVEPFLKD TPLYTDNTAN
400
401
GIALLWAPRP FNLRSGRTRR ALDIPLVKNW YREHCPAGQP VKVRVSYQKL
450
451
LKYYVLNALK HRPPKAQKKR YLFRSFKATK FFQSTKLDWV EVGLQVCRQG
500
501
YNMLNLLIHR KNLNYLHLDY NFNLKPVKTL TTKERKKSRF GNAFHLCREV
550
551
LRLTKLVVDS HVQYRLGNVD AFQLADGLQY IFAHVGQLTG MYRYKYKLMR
600
601
QIRMCKDLKH LIYYRFNTGP VGKGPGCGFW AAGWRVWLFF MRGITPLLER
650
651
WLGNLLARQF EGRHSKGVAK TVTKQRVESH FDLELRAAVM HDILDMMPEG
700
701
IKQNKARTIL QHLSEAWRCW KANIPWKVPG LPTPIENMIL RYVKAKADWW
750
751
TNTAHYNRER IRRGATVDKT VCKKNLGRLT RLYLKAEQER QHNYLKDGPY
800
801
ITAEEAVAVY TTTVHWLESR RFSPIPFPPL SYKHDTKLLI LALERLKEAY
850
851
SVKSRLNQSQ REELGLIEQA YDNPHEALSR IKRHLLTQRA FKEVGIEFMD
900
901
LYSHLVPVYD VEPLEKITDA YLDQYLWYEA DKRRLFPPWI KPADTEPPPL
950
951
LVYKWCQGIN NLQDVWETSE GECNVMLESR FEKMYEKIDL TLLNRLLRLI
1000
1001
VDHNIADYMT AKNNVVINYK DMNHTNSYGI IRGLQFASFI VQYYGLVMDL
1050
1051
LVLGLHRASE MAGPPQMPND FLSFQDIATE AAHPIRLFCR YIDRIHIFFR
1100
1101
FTADEARDLI QRYLTEHPDP NNENIVGYNN KKCWPRDARM RLMKHDVNLG
1150
1151
RAVFWDIKNR LPRSVTTVQW ENSFVSVYSK DNPNLLFNMC GFECRILPKC
1200
1201
RTSYEEFTHK DGVWNLQNEV TKERTAQCFL RVDDESMQRF HNRVRQILMA
1250
1251
SGSTTFTKIV NKWNTALIGL MTYFREAVVN TQELLDLLVK CENKIQTRIK
1300
1301
IGLNSKMPSR FPPVVFYTPK ELGGLGMLSM GHVLIPQSDL RWSKQTDVGI
1350
1351
THFRSGMSHE EDQLIPNLYR YIQPWESEFI DSQRVWAEYA LKRQEAIAQN
1400
1401
RRLTLEDLED SWDRGIPRIN TLFQKDRHTL AYDKGWRVRT DFKQYQVLKQ
1450
1451
NPFWWTHQRH DGKLWNLNNY RTDMIQALGG VEGILEHTLF KGTYFPTWEG
1500
1501
LFWEKASGFE ESMKWKKLTN AQRSGLNQIP NRRFTLWWSP TINRANVYVG
1550
1551
FQVQLDLTGI FMHGKIPTLK ISLIQIFRAH LWQKIHESIV MDLCQVFDQE
1600
1601
LDALEIETVQ KETIHPRKSY KMNSSCADIL LFASYKWNVS RPSLLADSKD
1650
1651
VMDSTTTQKY WIDIQLRWGD YDSHDIERYA RAKFLDYTTD NMSIYPSPTG
1700
1701
VLIAIDLAYN LHSAYGNWFP GSKPLIQQAM AKIMKANPAL YVLRERIRKG
1750
1751
LQLYSSEPTE PYLSSQNYGE LFSNQIIWFV DDTNVYRVTI HKTFEGNLTT
1800
1801
KPINGAIFIF NPRTGQLFLK IIHTSVWAGQ KRLGQLAKWK TAEEVAALIR
1850
1851
SLPVEEQPKQ IIVTRKGMLD PLEVHLLDFP NIVIKGSELQ LPFQACLKVE
1900
1901
KFGDLILKAT EPQMVLFNLY DDWLKTISSY TAFSRLILIL RALHVNNDRA
1950
1951
KVILKPDKTT ITEPHHIWPT LTDEEWIKVE VQLKDLILAD YGKKNNVNVA
2000
2001
SLTQSEIRDI ILGMEISAPS QQRQQIAEIE KQTKEQSQLT ATQTRTVNKH
2050
2051
GDEIITSTTS NYETQTFSSK TEWRVRAISA ANLHLRTNHI YVSSDDIKET
2100
2101
GYTYILPKNV LKKFICISDL RAQIAGYLYG VSPPDNPQVK EIRCIVMVPQ
2150
2151
WGTHQTVHLP GQLPQHEYLK EMEPLGWIHT QPNESPQLSP QDVTTHAKIM
2200
2201
ADNPSWDGEK TIIITCSFTP GSCTLTAYKL TPSGYEWGRQ NTDKGNNPKG
2250
2251
YLPSHYERVQ MLLSDRFLGF FMVPAQSSWN YNFMGVRHDP NMKYELQLAN
2300
2301
PKEFYHEVHR PSHFLNFALL QEGEVYSADR EDLYA                
2335
 

Show the unformatted sequence.

Checksums:
CRC64:E823A15C60EA61C9
MD5:d397712ba7a2044e69d7fd843f0c317a

Structures

For those sequences which have a structure in the Protein DataBank, we use the mapping between UniProt, PDB and Pfam coordinate systems from the PDBe SIFTS project, to allow us to map Pfam domains onto UniProt three-dimensional structures. The table below shows the mapping between Pfam domains, this UniProt entry and a corresponding three dimensional structure.

Pfam family UniProt residues PDB ID PDB chain ID PDB residues View
JAB 2099 - 2205 3JCR A 2099 - 2205 Jmol OpenAstexViewer
4KIT C 2099 - 2205 Jmol OpenAstexViewer
5O9Z A 2099 - 2205 Jmol OpenAstexViewer
5XJC A 2099 - 2205 Jmol OpenAstexViewer
PRO8NT 58 - 209 5MQF A 58 - 209 Jmol OpenAstexViewer
5XJC A 58 - 209 Jmol OpenAstexViewer
61 - 209 3JCR A 61 - 209 Jmol OpenAstexViewer
63 - 209 5O9Z A 63 - 209 Jmol OpenAstexViewer
PROCN 395 - 801 3JCR A 395 - 801 Jmol OpenAstexViewer
5MQF A 395 - 801 Jmol OpenAstexViewer
5O9Z A 395 - 801 Jmol OpenAstexViewer
5XJC A 395 - 801 Jmol OpenAstexViewer
PROCT 2212 - 2314 3JCR A 2212 - 2314 Jmol OpenAstexViewer
2212 - 2319 5O9Z A 2212 - 2319 Jmol OpenAstexViewer
2212 - 2333 4KIT C 2212 - 2333 Jmol OpenAstexViewer
5XJC A 2212 - 2333 Jmol OpenAstexViewer
PRP8_domainIV 1760 - 1989 3E9L A 1760 - 1989 Jmol OpenAstexViewer
3JCR A 1760 - 1989 Jmol OpenAstexViewer
5MQF A 1760 - 1989 Jmol OpenAstexViewer
5O9Z A 1760 - 1989 Jmol OpenAstexViewer
5XJC A 1760 - 1989 Jmol OpenAstexViewer
1770 - 1989 4JK7 A 1770 - 1989 Jmol OpenAstexViewer
B 1770 - 1989 Jmol OpenAstexViewer
4JK8 B 1770 - 1989 Jmol OpenAstexViewer
4JK9 B 1770 - 1989 Jmol OpenAstexViewer
4JKA B 1770 - 1989 Jmol OpenAstexViewer
4JKB A 1770 - 1989 Jmol OpenAstexViewer
4JKC B 1770 - 1989 Jmol OpenAstexViewer
4JKD A 1770 - 1989 Jmol OpenAstexViewer
B 1770 - 1989 Jmol OpenAstexViewer
4JKE B 1770 - 1989 Jmol OpenAstexViewer
4JKF A 1770 - 1989 Jmol OpenAstexViewer
4JKH A 1770 - 1989 Jmol OpenAstexViewer
B 1770 - 1989 Jmol OpenAstexViewer
1771 - 1989 3ENB A 1771 - 1989 Jmol OpenAstexViewer
4JK8 A 1771 - 1989 Jmol OpenAstexViewer
4JK9 A 1771 - 1989 Jmol OpenAstexViewer
4JKA A 1771 - 1989 Jmol OpenAstexViewer
4JKB B 1771 - 1989 Jmol OpenAstexViewer
4JKC A 1771 - 1989 Jmol OpenAstexViewer
4JKE A 1771 - 1989 Jmol OpenAstexViewer
4JKF B 1771 - 1989 Jmol OpenAstexViewer
4JKG A 1771 - 1989 Jmol OpenAstexViewer
B 1771 - 1989 Jmol OpenAstexViewer
1774 - 1988 3ENB B 1774 - 1988 Jmol OpenAstexViewer
1831 - 1989 3LRU A 1831 - 1989 Jmol OpenAstexViewer
1839 - 1989 3LRU B 1839 - 1989 Jmol OpenAstexViewer
RRM_4 986 - 1077 3JCR A 986 - 1077 Jmol OpenAstexViewer
5MQF A 986 - 1077 Jmol OpenAstexViewer
5O9Z A 986 - 1077 Jmol OpenAstexViewer
5XJC A 986 - 1077 Jmol OpenAstexViewer
U5_2-snRNA_bdg 1210 - 1343 3JCR A 1210 - 1343 Jmol OpenAstexViewer
5MQF A 1210 - 1343 Jmol OpenAstexViewer
5O9Z A 1210 - 1343 Jmol OpenAstexViewer
5XJC A 1210 - 1343 Jmol OpenAstexViewer
U6-snRNA_bdg 1442 - 1600 3JCR A 1442 - 1600 Jmol OpenAstexViewer
5MQF A 1442 - 1600 Jmol OpenAstexViewer
5O9Z A 1442 - 1600 Jmol OpenAstexViewer
5XJC A 1442 - 1600 Jmol OpenAstexViewer

TreeFam

Below is a phylogenetic tree of animal genes, with ortholog and paralog assignments, from TreeFam.