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1  structure 1  species 0  interactions 1  sequence 1  architecture

Protein: FIP1_HUMAN (Q6UN15)

Summary

This is the summary of UniProt entry FIP1_HUMAN (Q6UN15).

Description: Pre-mRNA 3'-end-processing factor FIP1
Source organism: Homo sapiens (Human) (NCBI taxonomy ID 9606)
Length: 594 amino acids
Reference Proteome: ✓

Please note: when we start each new Pfam data release, we take a copy of the UniProt sequence database. This snapshot of UniProt forms the basis of the overview that you see here. It is important to note that, although some UniProt entries may be removed after a Pfam release, these entries will not be removed from Pfam until the next Pfam data release.

Pfam domains

Download the data used to generate the domain graphic in JSON format.

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Source Domain Start End
disorder n/a 1 117
low_complexity n/a 45 54
low_complexity n/a 79 95
disorder n/a 121 125
disorder n/a 133 143
disorder n/a 147 148
disorder n/a 150 154
Pfam Fip1 154 196
disorder n/a 158 161
disorder n/a 163 164
disorder n/a 210 222
disorder n/a 231 594
low_complexity n/a 274 285
low_complexity n/a 356 391
low_complexity n/a 384 406
low_complexity n/a 456 490
low_complexity n/a 502 517
low_complexity n/a 516 542
low_complexity n/a 540 556
low_complexity n/a 559 572

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Sequence information

This is the amino acid sequence of the UniProt sequence database entry with the accession Q6UN15. This sequence is stored in the Pfam database and updated with each new Pfam release, but this means that the sequence we store may differ from that stored by UniProt.

Sequence:
1
MSAGEVERLV SELSGGTGGD EEEEWLYGGP WDVHVHSDLA KDLDENEVER
50
51
PEEENASANP PSGIEDETAE NGVPKPKVTE TEDDSDSDSD DDEDDVHVTI
100
101
GDIKTGAPQY GSYGTAPVNL NIKTGGRVYG TTGTKVKGVD LDAPGSINGV
150
151
PLLEVDLDSF EDKPWRKPGA DLSDYFNYGF NEDTWKAYCE KQKRIRMGLE
200
201
VIPVTSTTNK ITAEDCTMEV TPGAEIQDGR FNLFKVQQGR TGNSEKETAL
250
251
PSTKAEFTSP PSLFKTGLPP SRNSTSSQSQ TSTASRKANS SVGKWQDRYG
300
301
RAESPDLRRL PGAIDVIGQT ITISRVEGRR RANENSNIQV LSERSATEVD
350
351
NNFSKPPPFF PPGAPPTHLP PPPFLPPPPT VSTAPPLIPP PGFPPPPGAP
400
401
PPSLIPTIES GHSSGYDSRS ARAFPYGNVA FPHLPGSAPS WPSLVDTSKQ
450
451
WDYYARREKD RDRERDRDRE RDRDRDRERE RTRERERERD HSPTPSVFNS
500
501
DEERYRYREY AERGYERHRA SREKEERHRE RRHREKEETR HKSSRSNSRR
550
551
RHESEEGDSH RRHKHKKSKR SKEGKEAGSE PAPEQESTEA TPAE      
594
 

Show the unformatted sequence.

Checksums:
CRC64:B391D142419ED061
MD5:fffdc13441994469738eafa7bdb52b85

Structures

For those sequences which have a structure in the Protein DataBank, we use the mapping between UniProt, PDB and Pfam coordinate systems from the PDBe SIFTS project, to allow us to map Pfam domains onto UniProt three-dimensional structures. The table below shows the mapping between Pfam domains, this UniProt entry and a corresponding three dimensional structure.

Pfam family UniProt residues PDB ID PDB chain ID PDB residues View
Fip1 161 - 191 7K95 C 161 - 191 Show 3D Structure View in InterPro
162 - 196 7K95 B 162 - 196 Show 3D Structure View in InterPro
×

The parts of the structure corresponding to the Pfam family are highlighted in blue.

Loading Structure Data

TreeFam

Below is a phylogenetic tree of animal genes, with ortholog and paralog assignments, from TreeFam.

AlphaFold Structure Prediction

The protein structure below has been predicted by DeepMind with AlphaFold. For more information, please visit the AlphaFold page for this protein.

Model confidence scale

  Very High (pLDDT > 90)
  Confident (90 > pLDDT > 70)
  Low (70 > pLDDT > 50)
  Very Low (pLDDT < 50)
Highly accurate protein structure prediction with AlphaFold. John Jumper, Richard Evans, Alexander Pritzel, Tim Green, Michael Figurnov, Olaf Ronneberger, Kathryn Tunyasuvunakool, Russ Bates, Augustin Žídek, Anna Potapenko, Alex Bridgland, Clemens Meyer, Simon A. A. Kohl, Andrew J. Ballard, Andrew Cowie, Bernardino Romera-Paredes, Stanislav Nikolov, Rishub Jain, Jonas Adler, Trevor Back, Stig Petersen, David Reiman, Ellen Clancy, Michal Zielinski, Martin Steinegger, Michalina Pacholska, Tamas Berghammer, Sebastian Bodenstein, David Silver, Oriol Vinyals, Andrew W. Senior, Koray Kavukcuoglu, Pushmeet Kohli & Demis Hassabis Nature 2021-07-15; DOI: 10.1038/s41586-021-03819-2;