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4  structures 1  species 0  interactions 1  sequence 1  architecture

Protein: IL34_HUMAN (Q6ZMJ4)

Summary

This is the summary of UniProt entry IL34_HUMAN (Q6ZMJ4).

Description: Interleukin-34
Source organism: Homo sapiens (Human) (NCBI taxonomy ID 9606)
Length: 242 amino acids
Reference Proteome: ✓

Please note: when we start each new Pfam data release, we take a copy of the UniProt sequence database. This snapshot of UniProt forms the basis of the overview that you see here. It is important to note that, although some UniProt entries may be removed after a Pfam release, these entries will not be removed from Pfam until the next Pfam data release.

Pfam domains

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Source Domain Start End
sig_p n/a 1 20
Pfam IL34 28 184
disorder n/a 210 238
low_complexity n/a 213 225
disorder n/a 241 242

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Sequence information

This is the amino acid sequence of the UniProt sequence database entry with the accession Q6ZMJ4. This sequence is stored in the Pfam database and updated with each new Pfam release, but this means that the sequence we store may differ from that stored by UniProt.

Sequence:
1
MPRGFTWLRY LGIFLGVALG NEPLEMWPLT QNEECTVTGF LRDKLQYRSR
50
51
LQYMKHYFPI NYKISVPYEG VFRIANVTRL QRAQVSEREL RYLWVLVSLS
100
101
ATESVQDVLL EGHPSWKYLQ EVETLLLNVQ QGLTDVEVSP KVESVLSLLN
150
151
APGPNLKLVR PKALLDNCFR VMELLYCSCC KQSSVLNWQD CEVPSPQSCS
200
201
PEPSLQYAAT QLYPPPPWSP SSPPHSTGSV RPVRAQGEGL LP        
242
 

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Checksums:
CRC64:D1D8CC74C77AB23F
MD5:faedeb845ba32a7af319269cce8242e3

Structures

For those sequences which have a structure in the Protein DataBank, we use the mapping between UniProt, PDB and Pfam coordinate systems from the PDBe SIFTS project, to allow us to map Pfam domains onto UniProt three-dimensional structures. The table below shows the mapping between Pfam domains, this UniProt entry and a corresponding three dimensional structure.

Pfam family UniProt residues PDB ID PDB chain ID PDB residues View
IL34 32 - 184 4DKC A 32 - 184 Jmol OpenAstexViewer
4DKD A 32 - 184 Jmol OpenAstexViewer
4DKF A 32 - 184 Jmol OpenAstexViewer
33 - 180 4DKE B 33 - 180 Jmol OpenAstexViewer
33 - 184 4DKC B 33 - 184 Jmol OpenAstexViewer
4DKD B 33 - 184 Jmol OpenAstexViewer
34 - 184 4DKE A 34 - 184 Jmol OpenAstexViewer
35 - 180 4DKF B 35 - 180 Jmol OpenAstexViewer

TreeFam

Below is a phylogenetic tree of animal genes, with ortholog and paralog assignments, from TreeFam.