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3  structures 1  species 0  interactions 1  sequence 1  architecture

Protein: RN111_HUMAN (Q6ZNA4)

Summary

This is the summary of UniProt entry RN111_HUMAN (Q6ZNA4).

Description: E3 ubiquitin-protein ligase Arkadia {ECO:0000305|PubMed:14657019}
Source organism: Homo sapiens (Human) (NCBI taxonomy ID 9606)
Length: 994 amino acids
Reference Proteome: ✓

Please note: when we start each new Pfam data release, we take a copy of the UniProt sequence database. This snapshot of UniProt forms the basis of the overview that you see here. It is important to note that, although some UniProt entries may be removed after a Pfam release, these entries will not be removed from Pfam until the next Pfam data release.

Pfam domains

Download the data used to generate the domain graphic in JSON format.

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Source Domain Start End
disorder n/a 15 41
Pfam RNF111_N 18 292
disorder n/a 47 52
disorder n/a 63 97
disorder n/a 100 106
disorder n/a 115 141
low_complexity n/a 129 151
disorder n/a 145 198
disorder n/a 212 237
disorder n/a 244 580
low_complexity n/a 252 275
low_complexity n/a 343 357
low_complexity n/a 505 520
low_complexity n/a 576 588
low_complexity n/a 599 610
disorder n/a 602 646
low_complexity n/a 606 610
low_complexity n/a 628 637
disorder n/a 649 813
low_complexity n/a 671 680
low_complexity n/a 749 763
low_complexity n/a 764 781
disorder n/a 825 835
low_complexity n/a 825 842
disorder n/a 844 845
disorder n/a 929 932
low_complexity n/a 929 940
Pfam zf-RING_2 940 983

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Sequence information

This is the amino acid sequence of the UniProt sequence database entry with the accession Q6ZNA4. This sequence is stored in the Pfam database and updated with each new Pfam release, but this means that the sequence we store may differ from that stored by UniProt.

Sequence:
1
MSQWTPEYNE LYTLKVDMKS EIPSDAPKTQ ESLKGILLHP EPIGAAKSFP
50
51
AGVEMINSKV GNEFSHLCDD SQKQEKEMNG NQQEQEKSLV VRKKRKSQQA
100
101
GPSYVQNCVK ENQGILGLRQ HLGTPSDEDN DSSFSDCLSS PSSSLHFGDS
150
151
DTVTSDEDKE VSVRHSQTIL NAKSRSHSAR SHKWPRTETE SVSGLLMKRP
200
201
CLHGSSLRRL PCRKRFVKNN SSQRTQKQKE RILMQRKKRE VLARRKYALL
250
251
PSSSSSSEND LSSESSSSSS TEGEEDLFVS ASENHQNNPA VPSGSIDEDV
300
301
VVIEASSTPQ VTANEEINVT STDSEVEIVT VGESYRSRST LGHSRSHWSQ
350
351
GSSSHASRPQ EPRNRSRIST VIQPLRQNAA EVVDLTVDED EPTVVPTTSA
400
401
RMESQATSAS INNSNPSTSE QASDTASAVT SSQPSTVSET SATLTSNSTT
450
451
GTSIGDDSRR TTSSAVTETG PPAMPRLPSC CPQHSPCGGS SQNHHALGHP
500
501
HTSCFQQHGH HFQHHHHHHH TPHPAVPVSP SFSDPACPVE RPPQVQAPCG
550
551
ANSSSGTSYH EQQALPVDLS NSGIRSHGSG SFHGASAFDP CCPVSSSRAA
600
601
IFGHQAAAAA PSQPLSSIDG YGSSMVAQPQ PQPPPQPSLS SCRHYMPPPY
650
651
ASLTRPLHHQ ASACPHSHGN PPPQTQPPPQ VDYVIPHPVH AFHSQISSHA
700
701
TSHPVAPPPP THLASTAAPI PQHLPPTHQP ISHHIPATAP PAQRLHPHEV
750
751
MQRMEVQRRR MMQHPTRAHE RPPPHPHRMH PNYGHGHHIH VPQTMSSHPR
800
801
QAPERSAWEL GIEAGVTAAT YTPGALHPHL AHYHAPPRLH HLQLGALPLM
850
851
VPDMAGYPHI RYISSGLDGT SFRGPFRGNF EELIHLEERL GNVNRGASQG
900
901
TIERCTYPHK YKKVTTDWFS QRKLHCKQDG EEGTEEDTEE KCTICLSILE
950
951
EGEDVRRLPC MHLFHQVCVD QWLITNKKCP ICRVDIEAQL PSES      
994
 

Show the unformatted sequence.

Checksums:
CRC64:7E387321E5F61FAB
MD5:643cf9060810a8972b668be6030fb967

Structures

For those sequences which have a structure in the Protein DataBank, we use the mapping between UniProt, PDB and Pfam coordinate systems from the PDBe SIFTS project, to allow us to map Pfam domains onto UniProt three-dimensional structures. The table below shows the mapping between Pfam domains, this UniProt entry and a corresponding three dimensional structure.

Pfam family UniProt residues PDB ID PDB chain ID PDB residues View
zf-RING_2 940 - 983 2KIZ A 15 - 58 Show 3D Structure View in InterPro
5LG0 A 15 - 58 Show 3D Structure View in InterPro
5LG7 A 15 - 58 Show 3D Structure View in InterPro
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The parts of the structure corresponding to the Pfam family are highlighted in blue.

Loading Structure Data

TreeFam

Below is a phylogenetic tree of animal genes, with ortholog and paralog assignments, from TreeFam.

AlphaFold Structure Prediction

The protein structure below has been predicted by DeepMind with AlphaFold. For more information, please visit the AlphaFold page for this protein.

Model confidence scale

  Very High (pLDDT > 90)
  Confident (90 > pLDDT > 70)
  Low (70 > pLDDT > 50)
  Very Low (pLDDT < 50)
Highly accurate protein structure prediction with AlphaFold. John Jumper, Richard Evans, Alexander Pritzel, Tim Green, Michael Figurnov, Olaf Ronneberger, Kathryn Tunyasuvunakool, Russ Bates, Augustin Žídek, Anna Potapenko, Alex Bridgland, Clemens Meyer, Simon A. A. Kohl, Andrew J. Ballard, Andrew Cowie, Bernardino Romera-Paredes, Stanislav Nikolov, Rishub Jain, Jonas Adler, Trevor Back, Stig Petersen, David Reiman, Ellen Clancy, Michal Zielinski, Martin Steinegger, Michalina Pacholska, Tamas Berghammer, Sebastian Bodenstein, David Silver, Oriol Vinyals, Andrew W. Senior, Koray Kavukcuoglu, Pushmeet Kohli & Demis Hassabis Nature 2021-07-15; DOI: 10.1038/s41586-021-03819-2;