Summary
This is the summary of UniProt entry SSH2_HUMAN (Q76I76).
| Description: | Protein phosphatase Slingshot homolog 2 EC=3.1.3.16 EC=3.1.3.48 |
| Source organism: |
Homo sapiens (Human)
(NCBI taxonomy ID
9606)
|
| Length: | 1423 amino acids |
| Reference Proteome: |
|
Please note: when we start each new Pfam data release, we take a copy of the UniProt sequence database. This snapshot of UniProt forms the basis of the overview that you see here. It is important to note that, although some UniProt entries may be removed after a Pfam release, these entries will not be removed from Pfam until the next Pfam data release.
Pfam domains
Download the data used to generate the domain graphic in JSON format.
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| Source | Domain | Start | End |
|---|---|---|---|
| disorder | n/a | 1 | 37 |
| low_complexity | n/a | 9 | 18 |
| disorder | n/a | 55 | 70 |
| disorder | n/a | 107 | 111 |
| disorder | n/a | 121 | 124 |
| disorder | n/a | 223 | 227 |
| disorder | n/a | 235 | 242 |
| Pfam | DEK_C | 249 | 302 |
| Pfam | DSPc | 315 | 445 |
| disorder | n/a | 458 | 461 |
| low_complexity | n/a | 459 | 469 |
| disorder | n/a | 488 | 496 |
| disorder | n/a | 498 | 499 |
| disorder | n/a | 502 | 510 |
| disorder | n/a | 581 | 582 |
| disorder | n/a | 584 | 585 |
| disorder | n/a | 587 | 596 |
| disorder | n/a | 603 | 606 |
| disorder | n/a | 608 | 609 |
| disorder | n/a | 612 | 641 |
| low_complexity | n/a | 623 | 637 |
| disorder | n/a | 666 | 680 |
| disorder | n/a | 682 | 687 |
| disorder | n/a | 690 | 735 |
| disorder | n/a | 749 | 754 |
| disorder | n/a | 760 | 761 |
| disorder | n/a | 763 | 765 |
| disorder | n/a | 767 | 1006 |
| low_complexity | n/a | 838 | 852 |
| low_complexity | n/a | 871 | 884 |
| disorder | n/a | 1011 | 1044 |
| disorder | n/a | 1046 | 1048 |
| disorder | n/a | 1055 | 1059 |
| disorder | n/a | 1061 | 1115 |
| disorder | n/a | 1128 | 1131 |
| disorder | n/a | 1136 | 1177 |
| disorder | n/a | 1187 | 1215 |
| disorder | n/a | 1217 | 1232 |
| disorder | n/a | 1235 | 1236 |
| disorder | n/a | 1242 | 1249 |
| disorder | n/a | 1284 | 1287 |
| disorder | n/a | 1292 | 1327 |
| disorder | n/a | 1344 | 1345 |
| disorder | n/a | 1361 | 1363 |
| disorder | n/a | 1367 | 1370 |
| disorder | n/a | 1376 | 1377 |
| disorder | n/a | 1385 | 1423 |
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Sequence information
This is the amino acid sequence of the UniProt sequence database entry with the accession Q76I76. This sequence is stored in the Pfam database and updated with each new Pfam release, but this means that the sequence we store may differ from that stored by UniProt.
| Sequence: | 1
MALVTVQRSP TPSTTSSPCA SEADSGEEEC RSQPRSISES FLTVKGAALF
50 51
LPRGNGSSTP RISHRRNKHA GDLQQHLQAM FILLRPEDNI RLAVRLESTY
100 101
QNRTRYMVVV STNGRQDTEE SIVLGMDFSS NDSSTCTMGL VLPLWSDTLI
150 151
HLDGDGGFSV STDNRVHIFK PVSVQAMWSA LQSLHKACEV ARAHNYYPGS
200 201
LFLTWVSYYE SHINSDQSSV NEWNAMQDVQ SHRPDSPALF TDIPTERERT
250 251
ERLIKTKLRE IMMQKDLENI TSKEIRTELE MQMVCNLREF KEFIDNEMIV
300 301
ILGQMDSPTQ IFEHVFLGSE WNASNLEDLQ NRGVRYILNV TREIDNFFPG
350 351
VFEYHNIRVY DEEATDLLAY WNDTYKFISK AKKHGSKCLV HCKMGVSRSA
400 401
STVIAYAMKE YGWNLDRAYD YVKERRTVTK PNPSFMRQLE EYQGILLASK
450 451
QRHNKLWRSH SDSDLSDHHE PICKPGLELN KKDITTSADQ IAEVKTMESH
500 501
PPIPPVFVEH MVPQDANQKG LCTKERMICL EFTSREFHAG QIEDELNLND
550 551
INGCSSGCCL NESKFPLDNC HASKALIQPG HVPEMANKFP DLTVEDLETD
600 601
ALKADMNVHL LPMEELTSPL KDPPMSPDPE SPSPQPSCQT EISDFSTDRI
650 651
DFFSALEKFV ELSQETRSRS FSHSRMEELG GGRNESCRLS VVEVAPSKVT
700 701
ADDQRSSSLS NTPHASEESS MDEEQSKAIS ELVSPDIFMQ SHSENAISVK
750 751
EIVTEIESIS QGVGQIQLKG DILPNPCHTP KKNSIHELLL ERAQTPENKP
800 801
GHMEQDEDSC TAQPELAKDS GMCNPEGCLT THSSIADLEE GEPAEGEQEL
850 851
QGSGMHPGAK WYPGSVRRAT LEFEERLRQE QEHHGAAPTC TSLSTRKNSK
900 901
NDSSVADLAP KGKSDEAPPE HSFVLKEPEM SKGKGKYSGS EAGSLSHSEQ
950 951
NATVPAPRVL EFDHLPDPQE GPGSDTGTQQ EGVLKDLRTV IPYQESETQA
1000 1001
VPLPLPKRVE IIEYTHIVTS PNHTGPGSEI ATSEKSGEQG LRKVNMEKSV
1050 1051
TVLCTLDENL NRTLDPNQVS LHPQVLPLPH SSSPEHNRPT DHPTSILSSP
1100 1101
EDRGSSLSTA LETAAPFVSH TTHLLSASLD YLHPQTMVHL EGFTEQSSTT
1150 1151
DEPSAEQVSW EESQESPLSS GSEVPYKDSQ LSSADLSLIS KLGDNTGELQ
1200 1201
EKMDPLPVAC RLPHSSSSEN IKSLSHSPGV VKERAKEIES RVVFQAGLTK
1250 1251
PSQMRRSASL AKLGYLDLCK DCLPEREPAS CESPHLKLLQ PFLRTDSGMH
1300 1301
AMEDQESLEN PGAPHNPEPT KSFVEQLTTT ECIVQSKPVE RPLVQYAKEF
1350 1351
GSSQQYLLPR AGLELTSSEG GLPVLQTQGL QCACPAPGLA VAPRQQHGRT
1400 1401
HPLRRLKKAN DKKRTTNPFY NTM
1423
Show the unformatted sequence. |
| Checksums: |
CRC64:23D0B59C97D6BE38
MD5:c399c4e9f2ecd18a932b67f6df4586c8
|
Structures
For those sequences which have a structure in the Protein DataBank, we use the mapping between UniProt, PDB and Pfam coordinate systems from the PDBe SIFTS project, to allow us to map Pfam domains onto UniProt three-dimensional structures. The table below shows the mapping between Pfam domains, this UniProt entry and a corresponding three dimensional structure.
| Pfam family | UniProt residues | PDB ID | PDB chain ID | PDB residues | View |
|---|---|---|---|---|---|
| DSPc | 315 - 445 | 2NT2 | A | 315 - 445 | NGL View in InterPro |
| B | 315 - 445 | NGL View in InterPro | |||
| C | 315 - 445 | NGL View in InterPro |
The parts of the structure corresponding to the Pfam family are highlighted in yellow.
Loading Structure Data
TreeFam
Below is a phylogenetic tree of animal genes, with ortholog and paralog assignments, from TreeFam.
