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4  structures 1  species 0  interactions 1  sequence 1  architecture

Protein: MARK2_HUMAN (Q7KZI7)

Summary

This is the summary of UniProt entry MARK2_HUMAN (Q7KZI7).

Description: Serine/threonine-protein kinase MARK2 EC=2.7.11.1 EC=2.7.11.26
Source organism: Homo sapiens (Human) (NCBI taxonomy ID 9606)
Length: 788 amino acids
Reference Proteome: ✓

Please note: when we start each new Pfam data release, we take a copy of the UniProt sequence database. This snapshot of UniProt forms the basis of the overview that you see here. It is important to note that, although some UniProt entries may be removed after a Pfam release, these entries will not be removed from Pfam until the next Pfam data release.

Pfam domains

Download the data used to generate the domain graphic in JSON format.

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Source Domain Start End
disorder n/a 1 44
disorder n/a 46 47
Pfam Pkinase 53 304
disorder n/a 314 321
Pfam UBA 324 360
disorder n/a 328 331
disorder n/a 334 335
disorder n/a 369 635
low_complexity n/a 511 525
disorder n/a 653 656
disorder n/a 658 687
disorder n/a 696 702
disorder n/a 704 706
disorder n/a 708 715
Pfam KA1 744 788

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Sequence information

This is the amino acid sequence of the UniProt sequence database entry with the accession Q7KZI7. This sequence is stored in the Pfam database and updated with each new Pfam release, but this means that the sequence we store may differ from that stored by UniProt.

Sequence:
1
MSSARTPLPT LNERDTEQPT LGHLDSKPSS KSNMIRGRNS ATSADEQPHI
50
51
GNYRLLKTIG KGNFAKVKLA RHILTGKEVA VKIIDKTQLN SSSLQKLFRE
100
101
VRIMKVLNHP NIVKLFEVIE TEKTLYLVME YASGGEVFDY LVAHGRMKEK
150
151
EARAKFRQIV SAVQYCHQKF IVHRDLKAEN LLLDADMNIK IADFGFSNEF
200
201
TFGNKLDTFC GSPPYAAPEL FQGKKYDGPE VDVWSLGVIL YTLVSGSLPF
250
251
DGQNLKELRE RVLRGKYRIP FYMSTDCENL LKKFLILNPS KRGTLEQIMK
300
301
DRWMNVGHED DELKPYVEPL PDYKDPRRTE LMVSMGYTRE EIQDSLVGQR
350
351
YNEVMATYLL LGYKSSELEG DTITLKPRPS ADLTNSSAPS PSHKVQRSVS
400
401
ANPKQRRFSD QAAGPAIPTS NSYSKKTQSN NAENKRPEED RESGRKASST
450
451
AKVPASPLPG LERKKTTPTP STNSVLSTST NRSRNSPLLE RASLGQASIQ
500
501
NGKDSLTMPG SRASTASASA AVSAARPRQH QKSMSASVHP NKASGLPPTE
550
551
SNCEVPRPST APQRVPVASP SAHNISSSGG APDRTNFPRG VSSRSTFHAG
600
601
QLRQVRDQQN LPYGVTPASP SGHSQGRRGA SGSIFSKFTS KFVRRNLSFR
650
651
FARRNLNEPE SKDRVETLRP HVVGSGGNDK EKEEFREAKP RSLRFTWSMK
700
701
TTSSMEPNEM MREIRKVLDA NSCQSELHEK YMLLCMHGTP GHEDFVQWEM
750
751
EVCKLPRLSL NGVRFKRISG TSMAFKNIAS KIANELKL             
788
 

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Checksums:
CRC64:F307BF4DDB543A70
MD5:623517a1f4c11124fed81195b66db89e

Structures

For those sequences which have a structure in the Protein DataBank, we use the mapping between UniProt, PDB and Pfam coordinate systems from the PDBe SIFTS project, to allow us to map Pfam domains onto UniProt three-dimensional structures. The table below shows the mapping between Pfam domains, this UniProt entry and a corresponding three dimensional structure.

Pfam family UniProt residues PDB ID PDB chain ID PDB residues View
Pkinase 53 - 304 3IEC A 53 - 304 Show 3D Structure View in InterPro
B 53 - 304 Show 3D Structure View in InterPro
C 53 - 304 Show 3D Structure View in InterPro
D 53 - 304 Show 3D Structure View in InterPro
5EAK A 53 - 304 Show 3D Structure View in InterPro
B 53 - 304 Show 3D Structure View in InterPro
5KZ7 A 53 - 304 Show 3D Structure View in InterPro
B 53 - 304 Show 3D Structure View in InterPro
5KZ8 A 53 - 304 Show 3D Structure View in InterPro
B 53 - 304 Show 3D Structure View in InterPro
UBA 324 - 360 3IEC A 324 - 360 Show 3D Structure View in InterPro
B 324 - 360 Show 3D Structure View in InterPro
C 324 - 360 Show 3D Structure View in InterPro
D 324 - 360 Show 3D Structure View in InterPro
5EAK A 324 - 360 Show 3D Structure View in InterPro
B 324 - 360 Show 3D Structure View in InterPro
5KZ7 A 324 - 360 Show 3D Structure View in InterPro
B 324 - 360 Show 3D Structure View in InterPro
5KZ8 A 324 - 360 Show 3D Structure View in InterPro
B 324 - 360 Show 3D Structure View in InterPro
×

The parts of the structure corresponding to the Pfam family are highlighted in blue.

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TreeFam

Below is a phylogenetic tree of animal genes, with ortholog and paralog assignments, from TreeFam.

AlphaFold Structure Prediction

The protein structure below has been predicted by DeepMind with AlphaFold. For more information, please visit the AlphaFold page for this protein.

Model confidence scale

  Very High (pLDDT > 90)
  Confident (90 > pLDDT > 70)
  Low (70 > pLDDT > 50)
  Very Low (pLDDT < 50)
Highly accurate protein structure prediction with AlphaFold. John Jumper, Richard Evans, Alexander Pritzel, Tim Green, Michael Figurnov, Olaf Ronneberger, Kathryn Tunyasuvunakool, Russ Bates, Augustin Žídek, Anna Potapenko, Alex Bridgland, Clemens Meyer, Simon A. A. Kohl, Andrew J. Ballard, Andrew Cowie, Bernardino Romera-Paredes, Stanislav Nikolov, Rishub Jain, Jonas Adler, Trevor Back, Stig Petersen, David Reiman, Ellen Clancy, Michal Zielinski, Martin Steinegger, Michalina Pacholska, Tamas Berghammer, Sebastian Bodenstein, David Silver, Oriol Vinyals, Andrew W. Senior, Koray Kavukcuoglu, Pushmeet Kohli & Demis Hassabis Nature 2021-07-15; DOI: 10.1038/s41586-021-03819-2;