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6  structures 1  species 0  interactions 1  sequence 1  architecture

Protein: NUP54_HUMAN (Q7Z3B4)

Summary

This is the summary of UniProt entry NUP54_HUMAN (Q7Z3B4).

Description: Nucleoporin p54
Source organism: Homo sapiens (Human) (NCBI taxonomy ID 9606)
View Pfam proteome data.
Length: 507 amino acids
Reference Proteome: ✓

Please note: when we start each new Pfam data release, we take a copy of the UniProt sequence database. This snapshot of UniProt forms the basis of the overview that you see here. It is important to note that, although some UniProt entries may be removed after a Pfam release, these entries will not be removed from Pfam until the next Pfam data release.

Pfam domains

Download the data used to generate the domain graphic in JSON format.

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Source Domain Start End
low_complexity n/a 4 44
disorder n/a 13 23
disorder n/a 26 27
disorder n/a 39 41
low_complexity n/a 44 55
disorder n/a 49 54
low_complexity n/a 52 105
disorder n/a 64 65
disorder n/a 96 109
disorder n/a 111 112
disorder n/a 114 118
disorder n/a 158 159
disorder n/a 225 230
disorder n/a 255 258
disorder n/a 290 295
Pfam Nup54 300 438
disorder n/a 307 310
coiled_coil n/a 344 364
disorder n/a 356 357
Pfam Nup54_C 453 491

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Sequence information

This is the amino acid sequence of the UniProt sequence database entry with the accession Q7Z3B4. This sequence is stored in the Pfam database and updated with each new Pfam release, but this means that the sequence we store may differ from that stored by UniProt.

Sequence:
1
MAFNFGAPSG TSGTAAATAA PAGGFGGFGT TSTTAGSAFS FSAPTNTGTT
50
51
GLFGGTQNKG FGFGTGFGTT TGTSTGLGTG LGTGLGFGGF NTQQQQQTTL
100
101
GGLFSQPTQA PTQSNQLINT ASALSAPTLL GDERDAILAK WNQLQAFWGT
150
151
GKGYFNNNIP PVEFTQENPF CRFKAVGYSC MPSNKDEDGL VVLVFNKKET
200
201
EIRSQQQQLV ESLHKVLGGN QTLTVNVEGT KTLPDDQTEV VIYVVERSPN
250
251
GTSRRVPATT LYAHFEQANI KTQLQQLGVT LSMTRTELSP AQIKQLLQNP
300
301
PAGVDPIIWE QAKVDNPDSE KLIPVPMVGF KELLRRLKVQ DQMTKQHQTR
350
351
LDIISEDISE LQKNQTTSVA KIAQYKRKLM DLSHRTLQVL IKQEIQRKSG
400
401
YAIQADEEQL RVQLDTIQGE LNAPTQFKGR LNELMSQIRM QNHFGAVRSE
450
451
ERYYIDADLL REIKQHLKQQ QEGLSHLISI IKDDLEDIKL VEHGLNETIH
500
501
IRGGVFS                                               
507
 

Show the unformatted sequence.

Checksums:
CRC64:B5D235E01F1FE467
MD5:c9ddca4904950f36444729ce8e7a4e5f

Structures

For those sequences which have a structure in the Protein DataBank, we use the mapping between UniProt, PDB and Pfam coordinate systems from the PDBe SIFTS project, to allow us to map Pfam domains onto UniProt three-dimensional structures. The table below shows the mapping between Pfam domains, this UniProt entry and a corresponding three dimensional structure.

Pfam family UniProt residues PDB ID PDB chain ID PDB residues View
Nup54 300 - 438 5IJN F 300 - 438 Jmol OpenAstexViewer
L 300 - 438 Jmol OpenAstexViewer
R 300 - 438 Jmol OpenAstexViewer
X 300 - 438 Jmol OpenAstexViewer
5IJO F 300 - 438 Jmol OpenAstexViewer
L 300 - 438 Jmol OpenAstexViewer
R 300 - 438 Jmol OpenAstexViewer
X 300 - 438 Jmol OpenAstexViewer
Nup54_C 453 - 482 4JNV A 452 - 481 Jmol OpenAstexViewer
453 - 483 4JNV C 452 - 482 Jmol OpenAstexViewer
453 - 489 4JO9 C 456 - 492 Jmol OpenAstexViewer
453 - 491 4JNU A 452 - 490 Jmol OpenAstexViewer
B 453 - 491 Jmol OpenAstexViewer
C 454 - 492 Jmol OpenAstexViewer
D 453 - 491 Jmol OpenAstexViewer
4JO7 B 453 - 491 Jmol OpenAstexViewer
D 453 - 491 Jmol OpenAstexViewer
F 453 - 491 Jmol OpenAstexViewer
H 453 - 491 Jmol OpenAstexViewer
5IJN F 453 - 491 Jmol OpenAstexViewer
L 453 - 491 Jmol OpenAstexViewer
R 453 - 491 Jmol OpenAstexViewer
X 453 - 491 Jmol OpenAstexViewer
5IJO F 453 - 491 Jmol OpenAstexViewer
L 453 - 491 Jmol OpenAstexViewer
R 453 - 491 Jmol OpenAstexViewer
X 453 - 491 Jmol OpenAstexViewer
454 - 491 4JO9 A 457 - 494 Jmol OpenAstexViewer
458 - 491 4JNV B 457 - 490 Jmol OpenAstexViewer
461 - 491 4JNV D 460 - 490 Jmol OpenAstexViewer

TreeFam

Below is a phylogenetic tree of animal genes, with ortholog and paralog assignments, from TreeFam.