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0  structures 1  species 0  interactions 1  sequence 1  architecture

Protein: TMC4_HUMAN (Q7Z404)

Summary

This is the summary of UniProt entry TMC4_HUMAN (Q7Z404).

Description: Transmembrane channel-like protein 4
Source organism: Homo sapiens (Human) (NCBI taxonomy ID 9606)
Length: 712 amino acids
Reference Proteome: ✓

Please note: when we start each new Pfam data release, we take a copy of the UniProt sequence database. This snapshot of UniProt forms the basis of the overview that you see here. It is important to note that, although some UniProt entries may be removed after a Pfam release, these entries will not be removed from Pfam until the next Pfam data release.

Pfam domains

Download the data used to generate the domain graphic in JSON format.

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Source Domain Start End
disorder n/a 1 45
disorder n/a 54 104
disorder n/a 106 115
disorder n/a 126 129
low_complexity n/a 164 180
transmembrane n/a 169 191
low_complexity n/a 192 209
disorder n/a 201 206
transmembrane n/a 251 270
low_complexity n/a 342 362
transmembrane n/a 345 369
transmembrane n/a 394 414
transmembrane n/a 426 449
Pfam TMC 475 585
transmembrane n/a 484 502
low_complexity n/a 487 501
low_complexity n/a 559 572
transmembrane n/a 589 613
transmembrane n/a 655 678

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Sequence information

This is the amino acid sequence of the UniProt sequence database entry with the accession Q7Z404. This sequence is stored in the Pfam database and updated with each new Pfam release, but this means that the sequence we store may differ from that stored by UniProt.

Sequence:
1
MEENPTLESE AWGSSRGWLA PREARGAPCS SPGPSLSSVL NELPSAATLR
50
51
YRDPGVLPWG ALEEEEEDGG RSRKAFTEVT QTELQDPHPS RELPWPMQAR
100
101
RAHRQRNASR DQVVYGSGTK TDRWARLLRR SKEKTKEGLR SLQPWAWTLK
150
151
RIGGQFGAGT ESYFSLLRFL LLLNVLASVL MACMTLLPTW LGGAPPGPPG
200
201
PDISSPCGSY NPHSQGLVTF ATQLFNLLSG EGYLEWSPLF YGFYPPRPRL
250
251
AVTYLCWAFA VGLICLLLIL HRSVSGLKQT LLAESEALTS YSHRVFSAWD
300
301
FGLCGDVHVR LRQRIILYEL KVELEETVVR RQAAVRTLGQ QARVWLVRVL
350
351
LNLLVVALLG AAFYGVYWAT GCTVELQEMP LVQELPLLKL GVNYLPSIFI
400
401
AGVNFVLPPV FKLIAPLEGY TRSRQIVFIL LRTVFLRLAS LVVLLFSLWN
450
451
QITCGGDSEA EDCKTCGYNY KQLPCWETVL GQEMYKLLLF DLLTVLAVAL
500
501
LIQFPRKLLC GLCPGALGRL AGTQEFQVPD EVLGLIYAQT VVWVGSFFCP
550
551
LLPLLNTVKF LLLFYLKKLT LFSTCSPAAR TFRASAANFF FPLVLLLGLA
600
601
ISSVPLLYSI FLIPPSKLCG PFRGQSSIWA QIPESISSLP ETTQNFLFFL
650
651
GTQAFAVPLL LISSILMAYT VALANSYGRL ISELKRQRQT EAQNKVFLAR
700
701
RAVALTSTKP AL                                         
712
 

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Checksums:
CRC64:9816A5014A95C9F3
MD5:7b9a7ea8671f37b0018efd9b7cf53bc0

TreeFam

Below is a phylogenetic tree of animal genes, with ortholog and paralog assignments, from TreeFam.

AlphaFold Structure Prediction

The protein structure below has been predicted by DeepMind with AlphaFold. For more information, please visit the AlphaFold page for this protein.

Model confidence scale

  Very High (pLDDT > 90)
  Confident (90 > pLDDT > 70)
  Low (70 > pLDDT > 50)
  Very Low (pLDDT < 50)
Highly accurate protein structure prediction with AlphaFold. John Jumper, Richard Evans, Alexander Pritzel, Tim Green, Michael Figurnov, Olaf Ronneberger, Kathryn Tunyasuvunakool, Russ Bates, Augustin Žídek, Anna Potapenko, Alex Bridgland, Clemens Meyer, Simon A. A. Kohl, Andrew J. Ballard, Andrew Cowie, Bernardino Romera-Paredes, Stanislav Nikolov, Rishub Jain, Jonas Adler, Trevor Back, Stig Petersen, David Reiman, Ellen Clancy, Michal Zielinski, Martin Steinegger, Michalina Pacholska, Tamas Berghammer, Sebastian Bodenstein, David Silver, Oriol Vinyals, Andrew W. Senior, Koray Kavukcuoglu, Pushmeet Kohli & Demis Hassabis Nature 2021-07-15; DOI: 10.1038/s41586-021-03819-2;