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0  structures 1  species 0  interactions 1  sequence 1  architecture

Protein: PCSK9_MOUSE (Q80W65)

Summary

This is the summary of UniProt entry PCSK9_MOUSE (Q80W65).

Description: Proprotein convertase subtilisin/kexin type 9 EC=3.4.21.-
Source organism: Mus musculus (Mouse) (NCBI taxonomy ID 10090)
View Pfam proteome data.
Length: 694 amino acids
Reference Proteome: ✓

Please note: when we start each new Pfam data release, we take a copy of the UniProt sequence database. This snapshot of UniProt forms the basis of the overview that you see here. It is important to note that, although some UniProt entries may be removed after a Pfam release, these entries will not be removed from Pfam until the next Pfam data release.

Pfam domains

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Source Domain Start End
sig_p n/a 1 34
low_complexity n/a 11 26
disorder n/a 170 173
disorder n/a 179 180
Pfam Peptidase_S8 180 432
disorder n/a 219 224
low_complexity n/a 284 291
disorder n/a 442 446
Pfam PCSK9_C1 452 534
low_complexity n/a 470 480
disorder n/a 474 475
low_complexity n/a 489 499
Pfam PCSK9_C2 538 603
disorder n/a 578 579
Pfam PCSK9_C3 605 685

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Sequence information

This is the amino acid sequence of the UniProt sequence database entry with the accession Q80W65. This sequence is stored in the Pfam database and updated with each new Pfam release, but this means that the sequence we store may differ from that stored by UniProt.

Sequence:
1
MGTHCSAWLR WPLLPLLPPL LLLLLLLCPT GAGAQDEDGD YEELMLALPS
50
51
QEDGLADEAA HVATATFRRC SKEAWRLPGT YIVVLMEETQ RLQIEQTAHR
100
101
LQTRAARRGY VIKVLHIFYD LFPGFLVKMS SDLLGLALKL PHVEYIEEDS
150
151
FVFAQSIPWN LERIIPAWHQ TEEDRSPDGS SQVEVYLLDT SIQGAHREIE
200
201
GRVTITDFNS VPEEDGTRFH RQASKCDSHG THLAGVVSGR DAGVAKGTSL
250
251
HSLRVLNCQG KGTVSGTLIG LEFIRKSQLI QPSGPLVVLL PLAGGYSRIL
300
301
NAACRHLART GVVLVAAAGN FRDDACLYSP ASAPEVITVG ATNAQDQPVT
350
351
LGTLGTNFGR CVDLFAPGKD IIGASSDCST CFMSQSGTSQ AAAHVAGIVA
400
401
RMLSREPTLT LAELRQRLIH FSTKDVINMA WFPEDQQVLT PNLVATLPPS
450
451
THETGGQLLC RTVWSAHSGP TRTATATARC APEEELLSCS SFSRSGRRRG
500
501
DWIEAIGGQQ VCKALNAFGG EGVYAVARCC LVPRANCSIH NTPAARAGLE
550
551
THVHCHQKDH VLTGCSFHWE VEDLSVRRQP ALRSRRQPGQ CVGHQAASVY
600
601
ASCCHAPGLE CKIKEHGISG PSEQVTVACE AGWTLTGCNV LPGASLTLGA
650
651
YSVDNLCVAR VHDTARADRT SGEATVAAAI CCRSRPSAKA SWVQ      
694
 

Show the unformatted sequence.

Checksums:
CRC64:977BD4BD1FAF98C0
MD5:08d77d1d2f7e8fdaaebc294258ad05c3

TreeFam

Below is a phylogenetic tree of animal genes, with ortholog and paralog assignments, from TreeFam.