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1  structure 1  species 0  interactions 1  sequence 1  architecture

Protein: SYVN1_HUMAN (Q86TM6)

Summary

This is the summary of UniProt entry SYVN1_HUMAN (Q86TM6).

Description: E3 ubiquitin-protein ligase synoviolin EC=2.3.2.27
Source organism: Homo sapiens (Human) (NCBI taxonomy ID 9606)
Length: 617 amino acids
Reference Proteome: ✓

Please note: when we start each new Pfam data release, we take a copy of the UniProt sequence database. This snapshot of UniProt forms the basis of the overview that you see here. It is important to note that, although some UniProt entries may be removed after a Pfam release, these entries will not be removed from Pfam until the next Pfam data release.

Pfam domains

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Source Domain Start End
sig_p n/a 1 20
transmembrane n/a 44 66
transmembrane n/a 103 120
transmembrane n/a 140 160
transmembrane n/a 172 194
transmembrane n/a 224 245
Pfam zf-RING_2 289 330
disorder n/a 331 377
low_complexity n/a 338 407
disorder n/a 379 381
disorder n/a 384 459
low_complexity n/a 416 469
low_complexity n/a 460 482
disorder n/a 465 469
disorder n/a 471 509
disorder n/a 511 512
disorder n/a 527 617
low_complexity n/a 536 568
low_complexity n/a 559 576
low_complexity n/a 570 584

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Sequence information

This is the amino acid sequence of the UniProt sequence database entry with the accession Q86TM6. This sequence is stored in the Pfam database and updated with each new Pfam release, but this means that the sequence we store may differ from that stored by UniProt.

Sequence:
1
MFRTAVMMAA SLALTGAVVA HAYYLKHQFY PTVVYLTKSS PSMAVLYIQA
50
51
FVLVFLLGKV MGKVFFGQLR AAEMEHLLER SWYAVTETCL AFTVFRDDFS
100
101
PRFVALFTLL LFLKCFHWLA EDRVDFMERS PNISWLFHCR IVSLMFLLGI
150
151
LDFLFVSHAY HSILTRGASV QLVFGFEYAI LMTMVLTIFI KYVLHSVDLQ
200
201
SENPWDNKAV YMLYTELFTG FIKVLLYMAF MTIMIKVHTF PLFAIRPMYL
250
251
AMRQFKKAVT DAIMSRRAIR NMNTLYPDAT PEELQAMDNV CIICREEMVT
300
301
GAKRLPCNHI FHTSCLRSWF QRQQTCPTCR MDVLRASLPA QSPPPPEPAD
350
351
QGPPPAPHPP PLLPQPPNFP QGLLPPFPPG MFPLWPPMGP FPPVPPPPSS
400
401
GEAVAPPSTS AAALSRPSGA ATTTAAGTSA TAASATASGP GSGSAPEAGP
450
451
APGFPFPPPW MGMPLPPPFA FPPMPVPPAG FAGLTPEELR ALEGHERQHL
500
501
EARLQSLRNI HTLLDAAMLQ INQYLTVLAS LGPPRPATSV NSTEETATTV
550
551
VAAASSTSIP SSEATTPTPG ASPPAPEMER PPAPESVGTE EMPEDGEPDA
600
601
AELRRRRLQK LESPVAH                                    
617
 

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Checksums:
CRC64:B8A6BACBAF9673C1
MD5:a15b99d829a9d59c3c5cedcee05fc648

Structures

For those sequences which have a structure in the Protein DataBank, we use the mapping between UniProt, PDB and Pfam coordinate systems from the PDBe SIFTS project, to allow us to map Pfam domains onto UniProt three-dimensional structures. The table below shows the mapping between Pfam domains, this UniProt entry and a corresponding three dimensional structure.

Pfam family UniProt residues PDB ID PDB chain ID PDB residues View
zf-RING_2 289 - 330 6A3Z A 11 - 52 Jmol OpenAstexViewer

TreeFam

Below is a phylogenetic tree of animal genes, with ortholog and paralog assignments, from TreeFam.