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1  structure 1  species 0  interactions 1  sequence 1  architecture

Protein: KBTB6_HUMAN (Q86V97)

Summary

This is the summary of UniProt entry KBTB6_HUMAN (Q86V97).

Description: Kelch repeat and BTB domain-containing protein 6 {ECO:0000305}
Source organism: Homo sapiens (Human) (NCBI taxonomy ID 9606)
Length: 674 amino acids
Reference Proteome: ✓

Please note: when we start each new Pfam data release, we take a copy of the UniProt sequence database. This snapshot of UniProt forms the basis of the overview that you see here. It is important to note that, although some UniProt entries may be removed after a Pfam release, these entries will not be removed from Pfam until the next Pfam data release.

Pfam domains

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Source Domain Start End
disorder n/a 1 22
disorder n/a 25 28
Pfam BTB 53 168
Pfam BACK 173 278
low_complexity n/a 214 232
low_complexity n/a 310 329
disorder n/a 323 328
Pfam Kelch_1 424 471
low_complexity n/a 631 643
disorder n/a 641 650
low_complexity n/a 650 666
Pfam KBTB_W-LIR 663 674

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Sequence information

This is the amino acid sequence of the UniProt sequence database entry with the accession Q86V97. This sequence is stored in the Pfam database and updated with each new Pfam release, but this means that the sequence we store may differ from that stored by UniProt.

Sequence:
1
MQSREDAPRS RRLASPRGGK RPKKIHKPTV SAFFTGPEEL KDTAHSAALL
50
51
AQLKSFYDAR LLCDVTIEVV TPGSGPGTGR LFPCNRNVLA AACPYFKSMF
100
101
TGGMYESQQA SVTMHDVDAE SFEVLVDYCY TGRVSLSEAN VERLYAASDM
150
151
LQLEYVREAC ASFLARRLDL TNCTAILKFA DAFGHRKLRS QAQSYIAQNF
200
201
KQLSHMGSIR EETLADLTLA QLLAVLRLDS LDVESEQTVC HVAVQWLEAA
250
251
PKERGPSAAE VFKCVRWMHF TEEDQDYLEG LLTKPIVKKY CLDVIEGALQ
300
301
MRYGDLLYKS LVPVPNSSSS SSSSNSLVSA AENPPQRLGM CAKEMVIFFG
350
351
HPRDPFLCCD PYSGDLYKVP SPLTCLAHTR TVTTLAVCIS PDHDIYLAAQ
400
401
PRTDLWVYKP AQNSWQQLAD RLLCREGMDV AYLNGYIYIL GGRDPITGVK
450
451
LKEVECYNVK RNQWALVAPL PHSFLSFDLM VIRDYLYALN SKRMFCYDPS
500
501
HNMWLKCVSL KRNDFQEACV FNEEIYCICD IPVMKVYNPV RAEWRQMNNI
550
551
PLVSETNNYR IIKHGQKLLL ITSRTPQWKK NRVTVYEYDI RGDQWINIGT
600
601
TLGLLQFDSN FFCLSARVYP SCLEPGQSFL TEEEEIPSES STEWDLGGFS
650
651
EPDSESGSSS SLSDDDFWVR VAPQ                            
674
 

Show the unformatted sequence.

Checksums:
CRC64:5ED49AAEC6350CB5
MD5:c29289f6b6078556f092b9e553b20be6

Structures

For those sequences which have a structure in the Protein DataBank, we use the mapping between UniProt, PDB and Pfam coordinate systems from the PDBe SIFTS project, to allow us to map Pfam domains onto UniProt three-dimensional structures. The table below shows the mapping between Pfam domains, this UniProt entry and a corresponding three dimensional structure.

Pfam family UniProt residues PDB ID PDB chain ID PDB residues View
KBTB_W-LIR 663 - 673 4XC2 E 663 - 673 Show 3D Structure View in InterPro
F 663 - 673 Show 3D Structure View in InterPro
G 663 - 673 Show 3D Structure View in InterPro
H 663 - 673 Show 3D Structure View in InterPro
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The parts of the structure corresponding to the Pfam family are highlighted in blue.

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TreeFam

Below is a phylogenetic tree of animal genes, with ortholog and paralog assignments, from TreeFam.

AlphaFold Structure Prediction

The protein structure below has been predicted by DeepMind with AlphaFold. For more information, please visit the AlphaFold page for this protein.

Model confidence scale

  Very High (pLDDT > 90)
  Confident (90 > pLDDT > 70)
  Low (70 > pLDDT > 50)
  Very Low (pLDDT < 50)
Highly accurate protein structure prediction with AlphaFold. John Jumper, Richard Evans, Alexander Pritzel, Tim Green, Michael Figurnov, Olaf Ronneberger, Kathryn Tunyasuvunakool, Russ Bates, Augustin Žídek, Anna Potapenko, Alex Bridgland, Clemens Meyer, Simon A. A. Kohl, Andrew J. Ballard, Andrew Cowie, Bernardino Romera-Paredes, Stanislav Nikolov, Rishub Jain, Jonas Adler, Trevor Back, Stig Petersen, David Reiman, Ellen Clancy, Michal Zielinski, Martin Steinegger, Michalina Pacholska, Tamas Berghammer, Sebastian Bodenstein, David Silver, Oriol Vinyals, Andrew W. Senior, Koray Kavukcuoglu, Pushmeet Kohli & Demis Hassabis Nature 2021-07-15; DOI: 10.1038/s41586-021-03819-2;