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0  structures 1  species 0  interactions 1  sequence 1  architecture

Protein: LAP4B_HUMAN (Q86VI4)

Summary

This is the summary of UniProt entry LAP4B_HUMAN (Q86VI4).

Description: Lysosomal-associated transmembrane protein 4B {ECO:0000305}
Source organism: Homo sapiens (Human) (NCBI taxonomy ID 9606)
Length: 317 amino acids
Reference Proteome: ✓

Please note: when we start each new Pfam data release, we take a copy of the UniProt sequence database. This snapshot of UniProt forms the basis of the overview that you see here. It is important to note that, although some UniProt entries may be removed after a Pfam release, these entries will not be removed from Pfam until the next Pfam data release.

Pfam domains

Download the data used to generate the domain graphic in JSON format.

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Source Domain Start End
disorder n/a 1 16
low_complexity n/a 10 28
disorder n/a 18 25
disorder n/a 27 30
disorder n/a 32 69
low_complexity n/a 48 74
transmembrane n/a 121 139
low_complexity n/a 124 139
low_complexity n/a 163 180
transmembrane n/a 165 185
transmembrane n/a 192 217
Pfam Mtp 225 316
transmembrane n/a 237 259
low_complexity n/a 245 257

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Sequence information

This is the amino acid sequence of the UniProt sequence database entry with the accession Q86VI4. This sequence is stored in the Pfam database and updated with each new Pfam release, but this means that the sequence we store may differ from that stored by UniProt.

Sequence:
1
MTSRTRVTWP SPPRPLPVPA AAAVAFGAKG TDPAEARSSR GIEEAGPRAH
50
51
GRAGREPERR RSRQQRRGGL QARRSTLLKT CARARATAPG AMKMVAPWTR
100
101
FYSNSCCLCC HVRTGTILLG VWYLIINAVV LLILLSALAD PDQYNFSSSE
150
151
LGGDFEFMDD ANMCIAIAIS LLMILICAMA TYGAYKQRAA WIIPFFCYQI
200
201
FDFALNMLVA ITVLIYPNSI QEYIRQLPPN FPYRDDVMSV NPTCLVLIIL
250
251
LFISIILTFK GYLISCVWNC YRYINGRNSS DVLVYVTSND TTVLLPPYDD
300
301
ATVNGAAKEP PPPYVSA                                    
317
 

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Checksums:
CRC64:4E93093E066BE948
MD5:5734d214c66be7822d731d8881a33b09

TreeFam

Below is a phylogenetic tree of animal genes, with ortholog and paralog assignments, from TreeFam.

AlphaFold Structure Prediction

The protein structure below has been predicted by DeepMind with AlphaFold. For more information, please visit the AlphaFold page for this protein.

Model confidence scale

  Very High (pLDDT > 90)
  Confident (90 > pLDDT > 70)
  Low (70 > pLDDT > 50)
  Very Low (pLDDT < 50)
Highly accurate protein structure prediction with AlphaFold. John Jumper, Richard Evans, Alexander Pritzel, Tim Green, Michael Figurnov, Olaf Ronneberger, Kathryn Tunyasuvunakool, Russ Bates, Augustin Žídek, Anna Potapenko, Alex Bridgland, Clemens Meyer, Simon A. A. Kohl, Andrew J. Ballard, Andrew Cowie, Bernardino Romera-Paredes, Stanislav Nikolov, Rishub Jain, Jonas Adler, Trevor Back, Stig Petersen, David Reiman, Ellen Clancy, Michal Zielinski, Martin Steinegger, Michalina Pacholska, Tamas Berghammer, Sebastian Bodenstein, David Silver, Oriol Vinyals, Andrew W. Senior, Koray Kavukcuoglu, Pushmeet Kohli & Demis Hassabis Nature 2021-07-15; DOI: 10.1038/s41586-021-03819-2;