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2  structures 1  species 0  interactions 1  sequence 1  architecture

Protein: HOOK3_HUMAN (Q86VS8)

Summary

This is the summary of UniProt entry HOOK3_HUMAN (Q86VS8).

Description: Protein Hook homolog 3
Source organism: Homo sapiens (Human) (NCBI taxonomy ID 9606)
Length: 718 amino acids
Reference Proteome: ✓

Please note: when we start each new Pfam data release, we take a copy of the UniProt sequence database. This snapshot of UniProt forms the basis of the overview that you see here. It is important to note that, although some UniProt entries may be removed after a Pfam release, these entries will not be removed from Pfam until the next Pfam data release.

Pfam domains

Download the data used to generate the domain graphic in JSON format.

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Source Domain Start End
Pfam HOOK_N 11 161
coiled_coil n/a 171 226
Pfam HOOK 184 709
disorder n/a 185 187
disorder n/a 189 190
disorder n/a 220 221
disorder n/a 225 249
coiled_coil n/a 244 350
low_complexity n/a 245 258
disorder n/a 283 294
disorder n/a 300 301
disorder n/a 303 304
disorder n/a 317 318
disorder n/a 350 356
coiled_coil n/a 354 430
disorder n/a 358 359
disorder n/a 407 412
disorder n/a 414 415
disorder n/a 438 451
disorder n/a 453 456
disorder n/a 474 483
coiled_coil n/a 489 537
disorder n/a 503 504
disorder n/a 528 532
disorder n/a 535 536
disorder n/a 538 540
coiled_coil n/a 541 572
disorder n/a 542 543
low_complexity n/a 543 557
disorder n/a 549 550
disorder n/a 554 557
disorder n/a 559 560
disorder n/a 563 564
disorder n/a 566 569
coiled_coil n/a 576 617
disorder n/a 583 584
disorder n/a 587 598
low_complexity n/a 591 607
disorder n/a 601 603
disorder n/a 615 635
coiled_coil n/a 630 650
disorder n/a 637 638
disorder n/a 644 653
disorder n/a 655 656
disorder n/a 680 718
low_complexity n/a 696 707

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Sequence information

This is the amino acid sequence of the UniProt sequence database entry with the accession Q86VS8. This sequence is stored in the Pfam database and updated with each new Pfam release, but this means that the sequence we store may differ from that stored by UniProt.

Sequence:
1
MFSVESLERA ELCESLLTWI QTFNVDAPCQ TVEDLTNGVV MAQVLQKIDP
50
51
AYFDENWLNR IKTEVGDNWR LKISNLKKIL KGILDYNHEI LGQQINDFTL
100
101
PDVNLIGEHS DAAELGRMLQ LILGCAVNCE QKQEYIQAIM MMEESVQHVV
150
151
MTAIQELMSK ESPVSAGNDA YVDLDRQLKK TTEELNEALS AKEEIAQRCH
200
201
ELDMQVAALQ EEKSSLLAEN QVLMERLNQS DSIEDPNSPA GRRHLQLQTQ
250
251
LEQLQEETFR LEAAKDDYRI RCEELEKEIS ELRQQNDELT TLADEAQSLK
300
301
DEIDVLRHSS DKVSKLEGQV ESYKKKLEDL GDLRRQVKLL EEKNTMYMQN
350
351
TVSLEEELRK ANAARSQLET YKRQVVELQN RLSEESKKAD KLDFEYKRLK
400
401
EKVDSLQKEK DRLRTERDSL KETIEELRCV QAQEGQLTTQ GLMPLGSQES
450
451
SDSLAAEIVT PEIREKLIRL QHENKMLKLN QEGSDNEKIA LLQSLLDDAN
500
501
LRKNELETEN RLVNQRLLEV QSQVEELQKS LQDQGSKAED SVLLKKKLEE
550
551
HLEKLHEANN ELQKKRAIIE DLEPRFNNSS LKIEELQEAL RKKEEEMKQM
600
601
EERYKKYLEK AKSVIRTLDP KQNQGAAPEI QALKNQLQER DRLFHSLEKE
650
651
YEKTKSQREM EEKYIVSAWY NMGMTLHKKA AEDRLASTGS GQSFLARQRQ
700
701
ATSSRRSYPG HVQPATAR                                   
718
 

Show the unformatted sequence.

Checksums:
CRC64:9528EC9C854D39FA
MD5:dfb43da4503592b14ab31b7fce2af325

Structures

For those sequences which have a structure in the Protein DataBank, we use the mapping between UniProt, PDB and Pfam coordinate systems from the PDBe SIFTS project, to allow us to map Pfam domains onto UniProt three-dimensional structures. The table below shows the mapping between Pfam domains, this UniProt entry and a corresponding three dimensional structure.

Pfam family UniProt residues PDB ID PDB chain ID PDB residues View
HOOK_N 11 - 158 5J8E A 11 - 158 Show 3D Structure View in InterPro
B 11 - 158 Show 3D Structure View in InterPro
11 - 160 6B9H A 11 - 160 Show 3D Structure View in InterPro
×

The parts of the structure corresponding to the Pfam family are highlighted in blue.

Loading Structure Data

TreeFam

Below is a phylogenetic tree of animal genes, with ortholog and paralog assignments, from TreeFam.

AlphaFold Structure Prediction

The protein structure below has been predicted by DeepMind with AlphaFold. For more information, please visit the AlphaFold page for this protein.

Model confidence scale

  Very High (pLDDT > 90)
  Confident (90 > pLDDT > 70)
  Low (70 > pLDDT > 50)
  Very Low (pLDDT < 50)
Highly accurate protein structure prediction with AlphaFold. John Jumper, Richard Evans, Alexander Pritzel, Tim Green, Michael Figurnov, Olaf Ronneberger, Kathryn Tunyasuvunakool, Russ Bates, Augustin Žídek, Anna Potapenko, Alex Bridgland, Clemens Meyer, Simon A. A. Kohl, Andrew J. Ballard, Andrew Cowie, Bernardino Romera-Paredes, Stanislav Nikolov, Rishub Jain, Jonas Adler, Trevor Back, Stig Petersen, David Reiman, Ellen Clancy, Michal Zielinski, Martin Steinegger, Michalina Pacholska, Tamas Berghammer, Sebastian Bodenstein, David Silver, Oriol Vinyals, Andrew W. Senior, Koray Kavukcuoglu, Pushmeet Kohli & Demis Hassabis Nature 2021-07-15; DOI: 10.1038/s41586-021-03819-2;