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25  structures 1  species 0  interactions 1  sequence 1  architecture

Protein: PARG_HUMAN (Q86W56)

Summary

This is the summary of UniProt entry PARG_HUMAN (Q86W56).

Description: Poly(ADP-ribose) glycohydrolase {ECO:0000303|PubMed:14527731}
Source organism: Homo sapiens (Human) (NCBI taxonomy ID 9606)
Length: 976 amino acids
Reference Proteome: ✓

Please note: when we start each new Pfam data release, we take a copy of the UniProt sequence database. This snapshot of UniProt forms the basis of the overview that you see here. It is important to note that, although some UniProt entries may be removed after a Pfam release, these entries will not be removed from Pfam until the next Pfam data release.

Pfam domains

Download the data used to generate the domain graphic in JSON format.

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Source Domain Start End
disorder n/a 1 76
disorder n/a 83 122
disorder n/a 124 238
disorder n/a 248 358
low_complexity n/a 291 303
disorder n/a 362 446
disorder n/a 450 456
disorder n/a 469 470
disorder n/a 517 524
Pfam PARG_cat 581 909
low_complexity n/a 879 893
disorder n/a 970 976

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Sequence information

This is the amino acid sequence of the UniProt sequence database entry with the accession Q86W56. This sequence is stored in the Pfam database and updated with each new Pfam release, but this means that the sequence we store may differ from that stored by UniProt.

Sequence:
1
MNAGPGCEPC TKRPRWGAAT TSPAASDARS FPSRQRRVLD PKDAHVQFRV
50
51
PPSSPACVPG RAGQHRGSAT SLVFKQKTIT SWMDTKGIKT AESESLDSKE
100
101
NNNTRIESMM SSVQKDNFYQ HNVEKLENVS QLSLDKSPTE KSTQYLNQHQ
150
151
TAAMCKWQNE GKHTEQLLES EPQTVTLVPE QFSNANIDRS PQNDDHSDTD
200
201
SEENRDNQQF LTTVKLANAK QTTEDEQARE AKSHQKCSKS CDPGEDCASC
250
251
QQDEIDVVPE SPLSDVGSED VGTGPKNDNK LTRQESCLGN SPPFEKESEP
300
301
ESPMDVDNSK NSCQDSEADE ETSPGFDEQE DGSSSQTANK PSRFQARDAD
350
351
IEFRKRYSTK GGEVRLHFQF EGGESRTGMN DLNAKLPGNI SSLNVECRNS
400
401
KQHGKKDSKI TDHFMRLPKA EDRRKEQWET KHQRTERKIP KYVPPHLSPD
450
451
KKWLGTPIEE MRRMPRCGIR LPLLRPSANH TVTIRVDLLR AGEVPKPFPT
500
501
HYKDLWDNKH VKMPCSEQNL YPVEDENGER TAGSRWELIQ TALLNKFTRP
550
551
QNLKDAILKY NVAYSKKWDF TALIDFWDKV LEEAEAQHLY QSILPDMVKI
600
601
ALCLPNICTQ PIPLLKQKMN HSITMSQEQI ASLLANAFFC TFPRRNAKMK
650
651
SEYSSYPDIN FNRLFEGRSS RKPEKLKTLF CYFRRVTEKK PTGLVTFTRQ
700
701
SLEDFPEWER CEKPLTRLHV TYEGTIEENG QGMLQVDFAN RFVGGGVTSA
750
751
GLVQEEIRFL INPELIISRL FTEVLDHNEC LIITGTEQYS EYTGYAETYR
800
801
WSRSHEDGSE RDDWQRRCTE IVAIDALHFR RYLDQFVPEK MRRELNKAYC
850
851
GFLRPGVSSE NLSAVATGNW GCGAFGGDAR LKALIQILAA AAAERDVVYF
900
901
TFGDSELMRD IYSMHIFLTE RKLTVGDVYK LLLRYYNEEC RNCSTPGPDI
950
951
KLYPFIYHAV ESCAETADHS GQRTGT                          
976
 

Show the unformatted sequence.

Checksums:
CRC64:D6646353C6D0180E
MD5:a067236822bc66afdac93f3f8507a1b6

Structures

For those sequences which have a structure in the Protein DataBank, we use the mapping between UniProt, PDB and Pfam coordinate systems from the PDBe SIFTS project, to allow us to map Pfam domains onto UniProt three-dimensional structures. The table below shows the mapping between Pfam domains, this UniProt entry and a corresponding three dimensional structure.

Pfam family UniProt residues PDB ID PDB chain ID PDB residues View
PARG_cat 581 - 909 4A0D A 581 - 909 Show 3D Structure View in InterPro
4B1G A 581 - 909 Show 3D Structure View in InterPro
4B1H A 581 - 909 Show 3D Structure View in InterPro
4B1I A 581 - 909 Show 3D Structure View in InterPro
4B1J A 581 - 909 Show 3D Structure View in InterPro
5A7R A 581 - 909 Show 3D Structure View in InterPro
5LHB A 581 - 909 Show 3D Structure View in InterPro
6HH6 A 581 - 909 Show 3D Structure View in InterPro
6HMK A 581 - 909 Show 3D Structure View in InterPro
6HML A 581 - 909 Show 3D Structure View in InterPro
6HMM A 581 - 909 Show 3D Structure View in InterPro
6HMN A 581 - 909 Show 3D Structure View in InterPro
6O9X A 581 - 909 Show 3D Structure View in InterPro
6O9Y A 581 - 909 Show 3D Structure View in InterPro
6OA0 A 581 - 909 Show 3D Structure View in InterPro
6OA1 A 581 - 909 Show 3D Structure View in InterPro
6OA3 A 581 - 909 Show 3D Structure View in InterPro
6OAK A 581 - 909 Show 3D Structure View in InterPro
6OAL A 581 - 909 Show 3D Structure View in InterPro
7KFP A 581 - 909 Show 3D Structure View in InterPro
7KG0 A 581 - 909 Show 3D Structure View in InterPro
7KG1 A 581 - 909 Show 3D Structure View in InterPro
7KG6 A 581 - 909 Show 3D Structure View in InterPro
7KG7 A 581 - 909 Show 3D Structure View in InterPro
7KG8 A 581 - 909 Show 3D Structure View in InterPro
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The parts of the structure corresponding to the Pfam family are highlighted in blue.

Loading Structure Data

TreeFam

Below is a phylogenetic tree of animal genes, with ortholog and paralog assignments, from TreeFam.

AlphaFold Structure Prediction

The protein structure below has been predicted by DeepMind with AlphaFold. For more information, please visit the AlphaFold page for this protein.

Model confidence scale

  Very High (pLDDT > 90)
  Confident (90 > pLDDT > 70)
  Low (70 > pLDDT > 50)
  Very Low (pLDDT < 50)
Highly accurate protein structure prediction with AlphaFold. John Jumper, Richard Evans, Alexander Pritzel, Tim Green, Michael Figurnov, Olaf Ronneberger, Kathryn Tunyasuvunakool, Russ Bates, Augustin Žídek, Anna Potapenko, Alex Bridgland, Clemens Meyer, Simon A. A. Kohl, Andrew J. Ballard, Andrew Cowie, Bernardino Romera-Paredes, Stanislav Nikolov, Rishub Jain, Jonas Adler, Trevor Back, Stig Petersen, David Reiman, Ellen Clancy, Michal Zielinski, Martin Steinegger, Michalina Pacholska, Tamas Berghammer, Sebastian Bodenstein, David Silver, Oriol Vinyals, Andrew W. Senior, Koray Kavukcuoglu, Pushmeet Kohli & Demis Hassabis Nature 2021-07-15; DOI: 10.1038/s41586-021-03819-2;