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3  structures 1  species 0  interactions 1  sequence 1  architecture

Protein: PA24D_HUMAN (Q86XP0)

Summary

This is the summary of UniProt entry PA24D_HUMAN (Q86XP0).

Description: Cytosolic phospholipase A2 delta {ECO:0000305}
Source organism: Homo sapiens (Human) (NCBI taxonomy ID 9606)
Length: 818 amino acids
Reference Proteome: ✓

Please note: when we start each new Pfam data release, we take a copy of the UniProt sequence database. This snapshot of UniProt forms the basis of the overview that you see here. It is important to note that, although some UniProt entries may be removed after a Pfam release, these entries will not be removed from Pfam until the next Pfam data release.

Pfam domains

Download the data used to generate the domain graphic in JSON format.

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Source Domain Start End
disorder n/a 1 12
Pfam C2 22 126
low_complexity n/a 131 142
disorder n/a 135 139
Pfam cPLA2_C2 163 270
low_complexity n/a 219 233
disorder n/a 224 227
Pfam PLA2_B 323 563
low_complexity n/a 338 351
disorder n/a 560 562
disorder n/a 564 566
disorder n/a 699 704
disorder n/a 706 714
disorder n/a 743 754
disorder n/a 803 804
disorder n/a 806 818

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Sequence information

This is the amino acid sequence of the UniProt sequence database entry with the accession Q86XP0. This sequence is stored in the Pfam database and updated with each new Pfam release, but this means that the sequence we store may differ from that stored by UniProt.

Sequence:
1
MESLSPGGPP GHPYQGEAST CWQLTVRVLE ARNLRWADLL SEADPYVILQ
50
51
LSTAPGMKFK TKTLTDTSHP VWNEAFRFLI QSQVKNVLEL SIYDEDSVTE
100
101
DDICFKVLYD ISEVLPGKLL RKTFSQSPQG EEELDVEFLM EETSDRPENL
150
151
ITNKVIVARE LSCLDVHLDS TGSTAVVADQ DKLELELVLK GSYEDTQTSF
200
201
LGTASAFRFH YMAALETELS GRLRSSRSNG WNGDNSAGYL TVPLRPLTIG
250
251
KEVTMDVPAP NAPGVRLQLK AEGCPEELAV HLGFNLCAEE QAFLSRRKQV
300
301
VAKALKQALQ LDRDLQEDEV PVVGIMATGG GARAMTSLYG HLLALQKLGL
350
351
LDCVTYFSGI SGSTWTMAHL YGDPEWSQRD LEGPIRYARE HLAKSKLEVF
400
401
SPERLASYRR ELELRAEQGH PTTFVDLWAL VLESMLHGQV MDQKLSGQRA
450
451
ALERGQNPLP LYLSLNVKEN NLETLDFKEW VEFSPYEVGF LKYGAFVPPE
500
501
LFGSEFFMGR LMRRIPEPRI CFLEAIWSNI FSLNLLDAWY DLTSSGESWK
550
551
QHIKDKTRSL EKEPLTTSGT SSRLEASWLQ PGTALAQAFK GFLTGRPLHQ
600
601
RSPNFLQGLQ LHQDYCSHKD FSTWADYQLD SMPSQLTPKE PRLCLVDAAY
650
651
FINTSSPSMF RPGRRLDLIL SFDYSLSAPF EALQQTELYC RARGLPFPRV
700
701
EPSPQDQHQP RECHLFSDPA CPEAPILLHF PLVNASFKDH SAPGVQRSPA
750
751
ELQGGQVDLT GATCPYTLSN MTYKEEDFER LLRLSDYNVQ TSQGAILQAL
800
801
RTALKHRTLE ARPPRAQT                                   
818
 

Show the unformatted sequence.

Checksums:
CRC64:06187324748A4C21
MD5:2819f6d82daef2c52b5e71442aeae6b9

Structures

For those sequences which have a structure in the Protein DataBank, we use the mapping between UniProt, PDB and Pfam coordinate systems from the PDBe SIFTS project, to allow us to map Pfam domains onto UniProt three-dimensional structures. The table below shows the mapping between Pfam domains, this UniProt entry and a corresponding three dimensional structure.

Pfam family UniProt residues PDB ID PDB chain ID PDB residues View
C2 22 - 125 5IXC A 22 - 125 Show 3D Structure View in InterPro
B 22 - 125 Show 3D Structure View in InterPro
5IZR C 22 - 125 Show 3D Structure View in InterPro
22 - 126 5IZ5 A 22 - 126 Show 3D Structure View in InterPro
B 22 - 126 Show 3D Structure View in InterPro
5IZR A 22 - 126 Show 3D Structure View in InterPro
B 22 - 126 Show 3D Structure View in InterPro
D 22 - 126 Show 3D Structure View in InterPro
cPLA2_C2 163 - 270 5IXC A 163 - 270 Show 3D Structure View in InterPro
B 163 - 270 Show 3D Structure View in InterPro
5IZ5 A 163 - 270 Show 3D Structure View in InterPro
B 163 - 270 Show 3D Structure View in InterPro
5IZR A 163 - 270 Show 3D Structure View in InterPro
B 163 - 270 Show 3D Structure View in InterPro
C 163 - 270 Show 3D Structure View in InterPro
D 163 - 270 Show 3D Structure View in InterPro
PLA2_B 323 - 534 5IXC B 323 - 534 Show 3D Structure View in InterPro
5IZR A 323 - 534 Show 3D Structure View in InterPro
C 323 - 534 Show 3D Structure View in InterPro
D 323 - 534 Show 3D Structure View in InterPro
323 - 536 5IXC A 323 - 536 Show 3D Structure View in InterPro
323 - 537 5IZR B 323 - 537 Show 3D Structure View in InterPro
323 - 541 5IZ5 B 323 - 541 Show 3D Structure View in InterPro
323 - 563 5IZ5 A 323 - 563 Show 3D Structure View in InterPro
×

The parts of the structure corresponding to the Pfam family are highlighted in blue.

Loading Structure Data

TreeFam

Below is a phylogenetic tree of animal genes, with ortholog and paralog assignments, from TreeFam.

AlphaFold Structure Prediction

The protein structure below has been predicted by DeepMind with AlphaFold. For more information, please visit the AlphaFold page for this protein.

Model confidence scale

  Very High (pLDDT > 90)
  Confident (90 > pLDDT > 70)
  Low (70 > pLDDT > 50)
  Very Low (pLDDT < 50)
Highly accurate protein structure prediction with AlphaFold. John Jumper, Richard Evans, Alexander Pritzel, Tim Green, Michael Figurnov, Olaf Ronneberger, Kathryn Tunyasuvunakool, Russ Bates, Augustin Žídek, Anna Potapenko, Alex Bridgland, Clemens Meyer, Simon A. A. Kohl, Andrew J. Ballard, Andrew Cowie, Bernardino Romera-Paredes, Stanislav Nikolov, Rishub Jain, Jonas Adler, Trevor Back, Stig Petersen, David Reiman, Ellen Clancy, Michal Zielinski, Martin Steinegger, Michalina Pacholska, Tamas Berghammer, Sebastian Bodenstein, David Silver, Oriol Vinyals, Andrew W. Senior, Koray Kavukcuoglu, Pushmeet Kohli & Demis Hassabis Nature 2021-07-15; DOI: 10.1038/s41586-021-03819-2;