Please note: this site relies heavily on the use of javascript. Without a javascript-enabled browser, this site will not function correctly. Please enable javascript and reload the page, or switch to a different browser.
5  structures 1  species 0  interactions 1  sequence 1  architecture

Protein: COPA_MOUSE (Q8CIE6)

Summary

This is the summary of UniProt entry COPA_MOUSE (Q8CIE6).

Description: Coatomer subunit alpha
Source organism: Mus musculus (Mouse) (NCBI taxonomy ID 10090)
View Pfam proteome data.
Length: 1224 amino acids
Reference Proteome: ✓

Please note: when we start each new Pfam data release, we take a copy of the UniProt sequence database. This snapshot of UniProt forms the basis of the overview that you see here. It is important to note that, although some UniProt entries may be removed after a Pfam release, these entries will not be removed from Pfam until the next Pfam data release.

Pfam domains

Download the data used to generate the domain graphic in JSON format.

Show or hide the data used to generate the graphic in JSON format.

Source Domain Start End
Pfam WD40 41 79
Pfam WD40 83 121
Pfam WD40 125 163
Pfam ANAPC4_WD40 211 303
Pfam Coatomer_WDAD 338 767
disorder n/a 397 409
disorder n/a 770 783
disorder n/a 785 796
disorder n/a 798 799
Pfam COPI_C 815 1224
disorder n/a 836 839
disorder n/a 841 895
low_complexity n/a 880 894
disorder n/a 899 900
disorder n/a 903 909
disorder n/a 918 919

Show or hide domain scores.

Sequence information

This is the amino acid sequence of the UniProt sequence database entry with the accession Q8CIE6. This sequence is stored in the Pfam database and updated with each new Pfam release, but this means that the sequence we store may differ from that stored by UniProt.

Sequence:
1
MLTKFETKSA RVKGLSFHPK RPWILTSLHN GVIQLWDYRM CTLIDKFDEH
50
51
DGPVRGIDFH KQQPLFVSGG DDYKIKVWNY KLRRCLFTLL GHLDYIRTTF
100
101
FHHEYPWILS ASDDQTIRVW NWQSRTCVCV LTGHNHYVMC AQFHPSEDLV
150
151
VSASLDQTVR VWDISGLRKK NLSPGAVESD VRGITGVDLF GTTDAVVKHV
200
201
LEGHDRGVNW AAFHPTMPLI VSGADDRQVK IWRMNESKAW EVDTCRGHYN
250
251
NVSCAVFHPR QELILSNSED KSIRVWDMSK RTGVQTFRRD HDRFWVLAAH
300
301
PNLNLFAAGH DGGMIVFKLE RERPAYAVHG NMLHYVKDRF LRQLDFNSSK
350
351
DVAVMQLRSG SKFPVFNMSY NPAENAVLLC TRASNLENST YDLYTIPKDA
400
401
DSQNPDAPEG KRSSGLTAVW VARNRFAVLD RMHSLLIKNL KNEITKKIQV
450
451
PNCDEIFYAG TGNLLLRDAD SITLFDVQQK RTLASVKISK VKYVIWSADM
500
501
SHVALLAKHA IVICNRKLDA LCNIHENIRV KSGAWDESGV FIYTTSNHIK
550
551
YAVTTGDHGI IRTLDLPIYV TRVKGNNVYC LDRECRPRVL TIDPTEFKFK
600
601
LALINRKYDE VLHMVRNAKL VGQSIIAYLQ KKGYPEVALH FVKDEKTRFS
650
651
LALECGNIEI ALEAAKALDD KNCWEKLGEV ALLQGNHQIV EMCYQRTKNF
700
701
DKLSFLYLIT GNLEKLRKMM KIAEIRKDMS GHYQNALYLG DVSERVRILK
750
751
NCGQKSLAYL SAATHGLDEE AESLKETFDP EKETIPDIDP NAKLLQPPAP
800
801
IMPLDTNWPL LTVSKGFFEG SIASKGKGGA LAADIDIDTV GTEGWGEDAE
850
851
LQLDEDGFVE APEGLGEDVL GKGQEEGGGW DVEEDLELPP ELDVPSGVSG
900
901
SAEDGFFVPP TKGTSPTQIW CNNSQLPVDH ILAGSFETAM RLLHDQVGVI
950
951
QFGPYKQLFL QTYARGRTTY QALPCLPSMY SYPNRNWKDA GLKNGVPAVG
1000
1001
LKLNDLIQRL QLCYQLTTVG KFEEAVEKFR SILLSVPLLV VDNKQEIAEA
1050
1051
QQLITICREY IVGLCMEIER KKLPKETLDQ QKRICEMAAY FTHSNLQPVH
1100
1101
MILVLRTALN LFFKLKNFKT AATFARRLLE LGPKPEVAQQ TRKILSACEK
1150
1151
NPTDACQLNY DMHNPFDICA ASYRPIYRGK PVEKCPLSGA CYSPEFKGQI
1200
1201
CRVTTVTEIG KDVIGLRISP LQFR                            
1224
 

Show the unformatted sequence.

Checksums:
CRC64:48AB72AD9CBDDD6B
MD5:79733f69279dd65138164c2c5444f0f3

Structures

For those sequences which have a structure in the Protein DataBank, we use the mapping between UniProt, PDB and Pfam coordinate systems from the PDBe SIFTS project, to allow us to map Pfam domains onto UniProt three-dimensional structures. The table below shows the mapping between Pfam domains, this UniProt entry and a corresponding three dimensional structure.

Pfam family UniProt residues PDB ID PDB chain ID PDB residues View
ANAPC4_WD40 211 - 303 5A1U C 211 - 303 Jmol OpenAstexViewer
5A1V C 211 - 303 Jmol OpenAstexViewer
K 211 - 303 Jmol OpenAstexViewer
T 211 - 303 Jmol OpenAstexViewer
5A1W C 211 - 303 Jmol OpenAstexViewer
5A1X C 211 - 303 Jmol OpenAstexViewer
K 211 - 303 Jmol OpenAstexViewer
5A1Y C 211 - 303 Jmol OpenAstexViewer
K 211 - 303 Jmol OpenAstexViewer
Coatomer_WDAD 338 - 767 5A1U C 338 - 767 Jmol OpenAstexViewer
5A1V C 338 - 767 Jmol OpenAstexViewer
K 338 - 767 Jmol OpenAstexViewer
T 338 - 767 Jmol OpenAstexViewer
5A1W C 338 - 767 Jmol OpenAstexViewer
5A1X C 338 - 767 Jmol OpenAstexViewer
K 338 - 767 Jmol OpenAstexViewer
5A1Y C 338 - 767 Jmol OpenAstexViewer
K 338 - 767 Jmol OpenAstexViewer
COPI_C 913 - 1224 5A1V K 913 - 1224 Jmol OpenAstexViewer
T 913 - 1224 Jmol OpenAstexViewer
5A1Y C 913 - 1224 Jmol OpenAstexViewer
K 913 - 1224 Jmol OpenAstexViewer
WD40 125 - 163 5A1U C 125 - 163 Jmol OpenAstexViewer
5A1V C 125 - 163 Jmol OpenAstexViewer
K 125 - 163 Jmol OpenAstexViewer
T 125 - 163 Jmol OpenAstexViewer
5A1W C 125 - 163 Jmol OpenAstexViewer
5A1X C 125 - 163 Jmol OpenAstexViewer
K 125 - 163 Jmol OpenAstexViewer
5A1Y C 125 - 163 Jmol OpenAstexViewer
K 125 - 163 Jmol OpenAstexViewer
41 - 79 5A1U C 41 - 79 Jmol OpenAstexViewer
5A1V C 41 - 79 Jmol OpenAstexViewer
K 41 - 79 Jmol OpenAstexViewer
T 41 - 79 Jmol OpenAstexViewer
5A1W C 41 - 79 Jmol OpenAstexViewer
5A1X C 41 - 79 Jmol OpenAstexViewer
K 41 - 79 Jmol OpenAstexViewer
5A1Y C 41 - 79 Jmol OpenAstexViewer
K 41 - 79 Jmol OpenAstexViewer
83 - 121 5A1U C 83 - 121 Jmol OpenAstexViewer
5A1V C 83 - 121 Jmol OpenAstexViewer
K 83 - 121 Jmol OpenAstexViewer
T 83 - 121 Jmol OpenAstexViewer
5A1W C 83 - 121 Jmol OpenAstexViewer
5A1X C 83 - 121 Jmol OpenAstexViewer
K 83 - 121 Jmol OpenAstexViewer
5A1Y C 83 - 121 Jmol OpenAstexViewer
K 83 - 121 Jmol OpenAstexViewer

TreeFam

Below is a phylogenetic tree of animal genes, with ortholog and paralog assignments, from TreeFam.