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9  structures 1  species 0  interactions 1  sequence 1  architecture

Protein: MFN1_HUMAN (Q8IWA4)

Summary

This is the summary of UniProt entry MFN1_HUMAN (Q8IWA4).

Description: Mitofusin-1
Source organism: Homo sapiens (Human) (NCBI taxonomy ID 9606)
Length: 741 amino acids
Reference Proteome: ✓

Please note: when we start each new Pfam data release, we take a copy of the UniProt sequence database. This snapshot of UniProt forms the basis of the overview that you see here. It is important to note that, although some UniProt entries may be removed after a Pfam release, these entries will not be removed from Pfam until the next Pfam data release.

Pfam domains

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Source Domain Start End
Pfam Dynamin_N 78 238
low_complexity n/a 315 326
low_complexity n/a 394 405
low_complexity n/a 562 572
disorder n/a 563 573
Pfam Fzo_mitofusin 575 735
coiled_coil n/a 688 732
disorder n/a 733 734
disorder n/a 737 738
disorder n/a 740 741

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Sequence information

This is the amino acid sequence of the UniProt sequence database entry with the accession Q8IWA4. This sequence is stored in the Pfam database and updated with each new Pfam release, but this means that the sequence we store may differ from that stored by UniProt.

Sequence:
1
MAEPVSPLKH FVLAKKAITA IFDQLLEFVT EGSHFVEATY KNPELDRIAT
50
51
EDDLVEMQGY KDKLSIIGEV LSRRHMKVAF FGRTSSGKSS VINAMLWDKV
100
101
LPSGIGHITN CFLSVEGTDG DKAYLMTEGS DEKKSVKTVN QLAHALHMDK
150
151
DLKAGCLVRV FWPKAKCALL RDDLVLVDSP GTDVTTELDS WIDKFCLDAD
200
201
VFVLVANSES TLMNTEKHFF HKVNERLSKP NIFILNNRWD ASASEPEYME
250
251
DVRRQHMERC LHFLVEELKV VNALEAQNRI FFVSAKEVLS ARKQKAQGMP
300
301
ESGVALAEGF HARLQEFQNF EQIFEECISQ SAVKTKFEQH TIRAKQILAT
350
351
VKNIMDSVNL AAEDKRHYSV EEREDQIDRL DFIRNQMNLL TLDVKKKIKE
400
401
VTEEVANKVS CAMTDEICRL SVLVDEFCSE FHPNPDVLKI YKSELNKHIE
450
451
DGMGRNLADR CTDEVNALVL QTQQEIIENL KPLLPAGIQD KLHTLIPCKK
500
501
FDLSYNLNYH KLCSDFQEDI VFRFSLGWSS LVHRFLGPRN AQRVLLGLSE
550
551
PIFQLPRSLA STPTAPTTPA TPDNASQEEL MITLVTGLAS VTSRTSMGII
600
601
IVGGVIWKTI GWKLLSVSLT MYGALYLYER LSWTTHAKER AFKQQFVNYA
650
651
TEKLRMIVSS TSANCSHQVK QQIATTFARL CQQVDITQKQ LEEEIARLPK
700
701
EIDQLEKIQN NSKLLRNKAV QLENELENFT KQFLPSSNEE S         
741
 

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Checksums:
CRC64:B7BDC22437E30A58
MD5:355a3caaf0753160fb074f1fecaccd5d

Structures

For those sequences which have a structure in the Protein DataBank, we use the mapping between UniProt, PDB and Pfam coordinate systems from the PDBe SIFTS project, to allow us to map Pfam domains onto UniProt three-dimensional structures. The table below shows the mapping between Pfam domains, this UniProt entry and a corresponding three dimensional structure.

Pfam family UniProt residues PDB ID PDB chain ID PDB residues View
Dynamin_N 78 - 238 5GNR A 78 - 238 Show 3D Structure View in InterPro
5GNS A 78 - 238 Show 3D Structure View in InterPro
5GNT A 78 - 238 Show 3D Structure View in InterPro
5GNU A 78 - 238 Show 3D Structure View in InterPro
5GO4 A 78 - 238 Show 3D Structure View in InterPro
5GOE A 78 - 238 Show 3D Structure View in InterPro
5GOF A 78 - 238 Show 3D Structure View in InterPro
5GOM A 78 - 238 Show 3D Structure View in InterPro
B 78 - 238 Show 3D Structure View in InterPro
5YEW A 78 - 238 Show 3D Structure View in InterPro
B 78 - 238 Show 3D Structure View in InterPro
C 78 - 238 Show 3D Structure View in InterPro
Fzo_mitofusin 698 - 735 5YEW A 698 - 735 Show 3D Structure View in InterPro
C 698 - 735 Show 3D Structure View in InterPro
704 - 705 5GO4 A 704 - 705 Show 3D Structure View in InterPro
729 - 735 5GOE A 729 - 735 Show 3D Structure View in InterPro
5GOF A 729 - 735 Show 3D Structure View in InterPro
5GOM A 729 - 735 Show 3D Structure View in InterPro
B 729 - 735 Show 3D Structure View in InterPro
5YEW B 729 - 735 Show 3D Structure View in InterPro
×

The parts of the structure corresponding to the Pfam family are highlighted in blue.

Loading Structure Data

TreeFam

Below is a phylogenetic tree of animal genes, with ortholog and paralog assignments, from TreeFam.

AlphaFold Structure Prediction

The protein structure below has been predicted by DeepMind with AlphaFold. For more information, please visit the AlphaFold page for this protein.

Model confidence scale

  Very High (pLDDT > 90)
  Confident (90 > pLDDT > 70)
  Low (70 > pLDDT > 50)
  Very Low (pLDDT < 50)
Highly accurate protein structure prediction with AlphaFold. John Jumper, Richard Evans, Alexander Pritzel, Tim Green, Michael Figurnov, Olaf Ronneberger, Kathryn Tunyasuvunakool, Russ Bates, Augustin Žídek, Anna Potapenko, Alex Bridgland, Clemens Meyer, Simon A. A. Kohl, Andrew J. Ballard, Andrew Cowie, Bernardino Romera-Paredes, Stanislav Nikolov, Rishub Jain, Jonas Adler, Trevor Back, Stig Petersen, David Reiman, Ellen Clancy, Michal Zielinski, Martin Steinegger, Michalina Pacholska, Tamas Berghammer, Sebastian Bodenstein, David Silver, Oriol Vinyals, Andrew W. Senior, Koray Kavukcuoglu, Pushmeet Kohli & Demis Hassabis Nature 2021-07-15; DOI: 10.1038/s41586-021-03819-2;