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1  structure 1  species 0  interactions 1  sequence 1  architecture

Protein: DCNL3_HUMAN (Q8IWE4)

Summary

This is the summary of UniProt entry DCNL3_HUMAN (Q8IWE4).

Description: DCN1-like protein 3
Source organism: Homo sapiens (Human) (NCBI taxonomy ID 9606)
Length: 304 amino acids
Reference Proteome: ✓

Please note: when we start each new Pfam data release, we take a copy of the UniProt sequence database. This snapshot of UniProt forms the basis of the overview that you see here. It is important to note that, although some UniProt entries may be removed after a Pfam release, these entries will not be removed from Pfam until the next Pfam data release.

Pfam domains

Download the data used to generate the domain graphic in JSON format.

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Source Domain Start End
disorder n/a 6 53
disorder n/a 63 84
coiled_coil n/a 81 108
Pfam Cullin_binding 162 276
low_complexity n/a 277 289
disorder n/a 284 304

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Sequence information

This is the amino acid sequence of the UniProt sequence database entry with the accession Q8IWE4. This sequence is stored in the Pfam database and updated with each new Pfam release, but this means that the sequence we store may differ from that stored by UniProt.

Sequence:
1
MGQCVTKCKN PSSTLGSKNG DREPSNKSHS RRGAGHREEQ VPPCGKPGGD
50
51
ILVNGTKKAE AATEACQLPT SSGDAGRESK SNAEESSLQR LEELFRRYKD
100
101
EREDAILEEG MERFCNDLCV DPTEFRVLLL AWKFQAATMC KFTRKEFFDG
150
151
CKAISADSID GICARFPSLL TEAKQEDKFK DLYRFTFQFG LDSEEGQRSL
200
201
HREIAIALWK LVFTQNNPPV LDQWLNFLTE NPSGIKGISR DTWNMFLNFT
250
251
QVIGPDLSNY SEDEAWPSLF DTFVEWEMER RKREGEGRGA LSSGPEGLCP
300
301
EEQT                                                  
304
 

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Checksums:
CRC64:4B190AEAE7557A78
MD5:c3ac878da9b2f472ce0d72ba09af609f

Structures

For those sequences which have a structure in the Protein DataBank, we use the mapping between UniProt, PDB and Pfam coordinate systems from the PDBe SIFTS project, to allow us to map Pfam domains onto UniProt three-dimensional structures. The table below shows the mapping between Pfam domains, this UniProt entry and a corresponding three dimensional structure.

Pfam family UniProt residues PDB ID PDB chain ID PDB residues View
Cullin_binding 162 - 276 4GBA A 162 - 276 Show 3D Structure View in InterPro
B 162 - 276 Show 3D Structure View in InterPro
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The parts of the structure corresponding to the Pfam family are highlighted in blue.

Loading Structure Data

TreeFam

Below is a phylogenetic tree of animal genes, with ortholog and paralog assignments, from TreeFam.

AlphaFold Structure Prediction

The protein structure below has been predicted by DeepMind with AlphaFold. For more information, please visit the AlphaFold page for this protein.

Model confidence scale

  Very High (pLDDT > 90)
  Confident (90 > pLDDT > 70)
  Low (70 > pLDDT > 50)
  Very Low (pLDDT < 50)
Highly accurate protein structure prediction with AlphaFold. John Jumper, Richard Evans, Alexander Pritzel, Tim Green, Michael Figurnov, Olaf Ronneberger, Kathryn Tunyasuvunakool, Russ Bates, Augustin Žídek, Anna Potapenko, Alex Bridgland, Clemens Meyer, Simon A. A. Kohl, Andrew J. Ballard, Andrew Cowie, Bernardino Romera-Paredes, Stanislav Nikolov, Rishub Jain, Jonas Adler, Trevor Back, Stig Petersen, David Reiman, Ellen Clancy, Michal Zielinski, Martin Steinegger, Michalina Pacholska, Tamas Berghammer, Sebastian Bodenstein, David Silver, Oriol Vinyals, Andrew W. Senior, Koray Kavukcuoglu, Pushmeet Kohli & Demis Hassabis Nature 2021-07-15; DOI: 10.1038/s41586-021-03819-2;