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0  structures 1  species 0  interactions 1  sequence 1  architecture

Protein: DI3L2_HUMAN (Q8IYB7)

Summary

This is the summary of UniProt entry DI3L2_HUMAN (Q8IYB7).

Description: DIS3-like exonuclease 2 {ECO:0000255|HAMAP-Rule:MF_03045}
Source organism: Homo sapiens (Human) (NCBI taxonomy ID 9606)
Length: 885 amino acids
Reference Proteome: ✓

Please note: when we start each new Pfam data release, we take a copy of the UniProt sequence database. This snapshot of UniProt forms the basis of the overview that you see here. It is important to note that, although some UniProt entries may be removed after a Pfam release, these entries will not be removed from Pfam until the next Pfam data release.

Pfam domains

Download the data used to generate the domain graphic in JSON format.

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Source Domain Start End
disorder n/a 1 51
Pfam Rrp44_CSD1 47 148
disorder n/a 122 143
disorder n/a 148 153
disorder n/a 166 173
disorder n/a 177 178
disorder n/a 202 204
disorder n/a 207 216
Pfam OB_Dis3 265 341
Pfam RNB 371 721
disorder n/a 504 505
disorder n/a 507 520
disorder n/a 604 606
disorder n/a 608 609
disorder n/a 732 733
disorder n/a 736 737
disorder n/a 739 740
Pfam Dis3l2_C_term 766 855
disorder n/a 818 822
disorder n/a 862 885
low_complexity n/a 867 882

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Sequence information

This is the amino acid sequence of the UniProt sequence database entry with the accession Q8IYB7. This sequence is stored in the Pfam database and updated with each new Pfam release, but this means that the sequence we store may differ from that stored by UniProt.

Sequence:
1
MSHPDYRMNL RPLGTPRGVS AVAGPHDIGA SPGDKKSKNR STRGKKKSIF
50
51
ETYMSKEDVS EGLKRGTLIQ GVLRINPKKF HEAFIPSPDG DRDIFIDGVV
100
101
ARNRALNGDL VVVKLLPEEH WKVVKPESND KETEAAYESD IPEELCGHHL
150
151
PQQSLKSYND SPDVIVEAQF DGSDSEDGHG ITQNVLVDGV KKLSVCVSEK
200
201
GREDGDAPVT KDETTCISQD TRALSEKSLQ RSAKVVYILE KKHSRAATGF
250
251
LKLLADKNSE LFRKYALFSP SDHRVPRIYV PLKDCPQDFV ARPKDYANTL
300
301
FICRIVDWKE DCNFALGQLA KSLGQAGEIE PETEGILTEY GVDFSDFSSE
350
351
VLECLPQGLP WTIPPEEFSK RRDLRKDCIF TIDPSTARDL DDALSCKPLA
400
401
DGNFKVGVHI ADVSYFVPEG SDLDKVAAER ATSVYLVQKV VPMLPRLLCE
450
451
ELCSLNPMSD KLTFSVIWTL TPEGKILDEW FGRTIIRSCT KLSYEHAQSM
500
501
IESPTEKIPA KELPPISPEH SSEEVHQAVL NLHGIAKQLR QQRFVDGALR
550
551
LDQLKLAFTL DHETGLPQGC HIYEYRESNK LVEEFMLLAN MAVAHKIHRA
600
601
FPEQALLRRH PPPQTRMLSD LVEFCDQMGL PVDFSSAGAL NKSLTQTFGD
650
651
DKYSLARKEV LTNMCSRPMQ MALYFCSGLL QDPAQFRHYA LNVPLYTHFT
700
701
SPIRRFADVL VHRLLAAALG YRERLDMAPD TLQKQADHCN DRRMASKRVQ
750
751
ELSTSLFFAV LVKESGPLES EAMVMGILKQ AFDVLVLRYG VQKRIYCNAL
800
801
ALRSHHFQKV GKKPELTLVW EPEDMEQEPA QQVITIFSLV EVVLQAESTA
850
851
LKYSAILKRP GTQGHLGPEK EEEESDGEPE DSSTS                
885
 

Show the unformatted sequence.

Checksums:
CRC64:0F6757DCD1975412
MD5:b8f71501cb232895f4b582568467e659

TreeFam

Below is a phylogenetic tree of animal genes, with ortholog and paralog assignments, from TreeFam.

AlphaFold Structure Prediction

The protein structure below has been predicted by DeepMind with AlphaFold. For more information, please visit the AlphaFold page for this protein.

Model confidence scale

  Very High (pLDDT > 90)
  Confident (90 > pLDDT > 70)
  Low (70 > pLDDT > 50)
  Very Low (pLDDT < 50)
Highly accurate protein structure prediction with AlphaFold. John Jumper, Richard Evans, Alexander Pritzel, Tim Green, Michael Figurnov, Olaf Ronneberger, Kathryn Tunyasuvunakool, Russ Bates, Augustin Žídek, Anna Potapenko, Alex Bridgland, Clemens Meyer, Simon A. A. Kohl, Andrew J. Ballard, Andrew Cowie, Bernardino Romera-Paredes, Stanislav Nikolov, Rishub Jain, Jonas Adler, Trevor Back, Stig Petersen, David Reiman, Ellen Clancy, Michal Zielinski, Martin Steinegger, Michalina Pacholska, Tamas Berghammer, Sebastian Bodenstein, David Silver, Oriol Vinyals, Andrew W. Senior, Koray Kavukcuoglu, Pushmeet Kohli & Demis Hassabis Nature 2021-07-15; DOI: 10.1038/s41586-021-03819-2;