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0  structures 1  species 0  interactions 1  sequence 1  architecture

Protein: HACE1_HUMAN (Q8IYU2)

Summary

This is the summary of UniProt entry HACE1_HUMAN (Q8IYU2).

Description: E3 ubiquitin-protein ligase HACE1 EC=2.3.2.26
Source organism: Homo sapiens (Human) (NCBI taxonomy ID 9606)
Length: 909 amino acids
Reference Proteome: ✓

Please note: when we start each new Pfam data release, we take a copy of the UniProt sequence database. This snapshot of UniProt forms the basis of the overview that you see here. It is important to note that, although some UniProt entries may be removed after a Pfam release, these entries will not be removed from Pfam until the next Pfam data release.

Pfam domains

Download the data used to generate the domain graphic in JSON format.

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Source Domain Start End
coiled_coil n/a 1 21
disorder n/a 16 19
Pfam Ank_2 34 128
Pfam Ank_2 125 194
Pfam Ank_2 191 258
disorder n/a 341 348
disorder n/a 389 391
disorder n/a 402 433
disorder n/a 542 543
Pfam HECT 602 909
disorder n/a 627 628

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Sequence information

This is the amino acid sequence of the UniProt sequence database entry with the accession Q8IYU2. This sequence is stored in the Pfam database and updated with each new Pfam release, but this means that the sequence we store may differ from that stored by UniProt.

Sequence:
1
MERAMEQLNR LTRSLRRART VELPEDNETA VYTLMPMVMA DQHRSVSELL
50
51
SNSKFDVNYA FGRVKRSLLH IAANCGSVEC LVLLLKKGAN PNYQDISGCT
100
101
PLHLAARNGQ KKCMSKLLEY SADVNICNNE GLTAIHWLAV NGRTELLHDL
150
151
VQHVSDVDVE DAMGQTALHV ACQNGHKTTV QCLLDSGADI NRPNVSGATP
200
201
LYFACSHGQR DTAQILLLRG AKYLPDKNGV TPLDLCVQGG YGETCEVLIQ
250
251
YHPRLFQTII QMTQNEDLRE NMLRQVLEHL SQQSESQYLK ILTSLAEVAT
300
301
TNGHKLLSLS SNYDAQMKSL LRIVRMFCHV FRIGPSSPSN GIDMGYNGNK
350
351
TPRSQVFKPL ELLWHSLDEW LVLIATELMK NKRDSTEITS ILLKQKGQDQ
400
401
DAASIPPFEP PGPGSYENLS TGTRESKPDA LAGRQEASAD CQDVISMTAN
450
451
RLSAVIQAFY MCCSCQMPPG MTSPRFIEFV CKHDEVLKCF VNRNPKIIFD
500
501
HFHFLLECPE LMSRFMHIIK AQPFKDRCEW FYEHLHSGQP DSDMVHRPVN
550
551
ENDILLVHRD SIFRSSCEVV SKANCAKLKQ GIAVRFHGEE GMGQGVVREW
600
601
FDILSNEIVN PDYALFTQSA DGTTFQPNSN SYVNPDHLNY FRFAGQILGL
650
651
ALNHRQLVNI YFTRSFYKHI LGIPVNYQDV ASIDPEYAKN LQWILDNDIS
700
701
DLGLELTFSV ETDVFGAMEE VPLKPGGGSI LVTQNNKAEY VQLVTELRMT
750
751
RAIQPQINAF LQGFHMFIPP SLIQLFDEYE LELLLSGMPE IDVSDWIKNT
800
801
EYTSGYERED PVIQWFWEVV EDITQEERVL LLQFVTGSSR VPHGGFANIM
850
851
GGSGLQNFTI AAVPYTPNLL PTSSTCINML KLPEYPSKEI LKDRLLVALH
900
901
CGSYGYTMA                                             
909
 

Show the unformatted sequence.

Checksums:
CRC64:8AEC09D9D29DC1D8
MD5:f02d550e730a1896eecc7ffe31d93a6e

TreeFam

Below is a phylogenetic tree of animal genes, with ortholog and paralog assignments, from TreeFam.

AlphaFold Structure Prediction

The protein structure below has been predicted by DeepMind with AlphaFold. For more information, please visit the AlphaFold page for this protein.

Model confidence scale

  Very High (pLDDT > 90)
  Confident (90 > pLDDT > 70)
  Low (70 > pLDDT > 50)
  Very Low (pLDDT < 50)
Highly accurate protein structure prediction with AlphaFold. John Jumper, Richard Evans, Alexander Pritzel, Tim Green, Michael Figurnov, Olaf Ronneberger, Kathryn Tunyasuvunakool, Russ Bates, Augustin Žídek, Anna Potapenko, Alex Bridgland, Clemens Meyer, Simon A. A. Kohl, Andrew J. Ballard, Andrew Cowie, Bernardino Romera-Paredes, Stanislav Nikolov, Rishub Jain, Jonas Adler, Trevor Back, Stig Petersen, David Reiman, Ellen Clancy, Michal Zielinski, Martin Steinegger, Michalina Pacholska, Tamas Berghammer, Sebastian Bodenstein, David Silver, Oriol Vinyals, Andrew W. Senior, Koray Kavukcuoglu, Pushmeet Kohli & Demis Hassabis Nature 2021-07-15; DOI: 10.1038/s41586-021-03819-2;