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0  structures 1  species 0  interactions 1  sequence 1  architecture

Protein: ABCA7_HUMAN (Q8IZY2)

Summary

This is the summary of UniProt entry ABCA7_HUMAN (Q8IZY2).

Description: ATP-binding cassette sub-family A member 7
Source organism: Homo sapiens (Human) (NCBI taxonomy ID 9606)
View Pfam proteome data.
Length: 2146 amino acids
Reference Proteome: ✓

Please note: when we start each new Pfam data release, we take a copy of the UniProt sequence database. This snapshot of UniProt forms the basis of the overview that you see here. It is important to note that, although some UniProt entries may be removed after a Pfam release, these entries will not be removed from Pfam until the next Pfam data release.

Pfam domains

Download the data used to generate the domain graphic in JSON format.

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Source Domain Start End
sig_p n/a 1 45
low_complexity n/a 24 36
disorder n/a 53 55
disorder n/a 136 152
low_complexity n/a 157 170
low_complexity n/a 182 196
disorder n/a 353 372
disorder n/a 445 458
Pfam ABC2_membrane_3 530 750
transmembrane n/a 550 570
transmembrane n/a 590 614
low_complexity n/a 599 620
transmembrane n/a 626 646
low_complexity n/a 626 640
transmembrane n/a 653 673
low_complexity n/a 734 746
disorder n/a 781 782
disorder n/a 785 791
disorder n/a 810 811
Pfam ABC_tran 824 968
disorder n/a 1048 1070
low_complexity n/a 1090 1103
disorder n/a 1183 1209
low_complexity n/a 1214 1238
transmembrane n/a 1239 1260
disorder n/a 1282 1284
low_complexity n/a 1291 1307
disorder n/a 1298 1299
disorder n/a 1311 1318
disorder n/a 1331 1332
disorder n/a 1339 1350
disorder n/a 1356 1379
low_complexity n/a 1359 1368
disorder n/a 1423 1428
Pfam ABC2_membrane_3 1433 1750
transmembrane n/a 1536 1558
transmembrane n/a 1578 1604
low_complexity n/a 1611 1624
transmembrane n/a 1616 1635
transmembrane n/a 1647 1671
transmembrane n/a 1683 1701
transmembrane n/a 1734 1752
low_complexity n/a 1741 1760
low_complexity n/a 1770 1783
disorder n/a 1779 1781
Pfam ABC_tran 1810 1954
low_complexity n/a 2032 2045
disorder n/a 2104 2124
disorder n/a 2127 2135
disorder n/a 2137 2139

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Sequence information

This is the amino acid sequence of the UniProt sequence database entry with the accession Q8IZY2. This sequence is stored in the Pfam database and updated with each new Pfam release, but this means that the sequence we store may differ from that stored by UniProt.

Sequence:
1
MAFWTQLMLL LWKNFMYRRR QPVQLLVELL WPLFLFFILV AVRHSHPPLE
50
51
HHECHFPNKP LPSAGTVPWL QGLICNVNNT CFPQLTPGEE PGRLSNFNDS
100
101
LVSRLLADAR TVLGGASAHR TLAGLGKLIA TLRAARSTAQ PQPTKQSPLE
150
151
PPMLDVAELL TSLLRTESLG LALGQAQEPL HSLLEAAEDL AQELLALRSL
200
201
VELRALLQRP RGTSGPLELL SEALCSVRGP SSTVGPSLNW YEASDLMELV
250
251
GQEPESALPD SSLSPACSEL IGALDSHPLS RLLWRRLKPL ILGKLLFAPD
300
301
TPFTRKLMAQ VNRTFEELTL LRDVREVWEM LGPRIFTFMN DSSNVAMLQR
350
351
LLQMQDEGRR QPRPGGRDHM EALRSFLDPG SGGYSWQDAH ADVGHLVGTL
400
401
GRVTECLSLD KLEAAPSEAA LVSRALQLLA EHRFWAGVVF LGPEDSSDPT
450
451
EHPTPDLGPG HVRIKIRMDI DVVTRTNKIR DRFWDPGPAA DPLTDLRYVW
500
501
GGFVYLQDLV ERAAVRVLSG ANPRAGLYLQ QMPYPCYVDD VFLRVLSRSL
550
551
PLFLTLAWIY SVTLTVKAVV REKETRLRDT MRAMGLSRAV LWLGWFLSCL
600
601
GPFLLSAALL VLVLKLGDIL PYSHPGVVFL FLAAFAVATV TQSFLLSAFF
650
651
SRANLAAACG GLAYFSLYLP YVLCVAWRDR LPAGGRVAAS LLSPVAFGFG
700
701
CESLALLEEQ GEGAQWHNVG TRPTADVFSL AQVSGLLLLD AALYGLATWY
750
751
LEAVCPGQYG IPEPWNFPFR RSYWCGPRPP KSPAPCPTPL DPKVLVEEAP
800
801
PGLSPGVSVR SLEKRFPGSP QPALRGLSLD FYQGHITAFL GHNGAGKTTT
850
851
LSILSGLFPP SGGSAFILGH DVRSSMAAIR PHLGVCPQYN VLFDMLTVDE
900
901
HVWFYGRLKG LSAAVVGPEQ DRLLQDVGLV SKQSVQTRHL SGGMQRKLSV
950
951
AIAFVGGSQV VILDEPTAGV DPASRRGIWE LLLKYREGRT LILSTHHLDE
1000
1001
AELLGDRVAV VAGGRLCCCG SPLFLRRHLG SGYYLTLVKA RLPLTTNEKA
1050
1051
DTDMEGSVDT RQEKKNGSQG SRVGTPQLLA LVQHWVPGAR LVEELPHELV
1100
1101
LVLPYTGAHD GSFATLFREL DTRLAELRLT GYGISDTSLE EIFLKVVEEC
1150
1151
AADTDMEDGS CGQHLCTGIA GLDVTLRLKM PPQETALENG EPAGSAPETD
1200
1201
QGSGPDAVGR VQGWALTRQQ LQALLLKRFL LARRSRRGLF AQIVLPALFV
1250
1251
GLALVFSLIV PPFGHYPALR LSPTMYGAQV SFFSEDAPGD PGRARLLEAL
1300
1301
LQEAGLEEPP VQHSSHRFSA PEVPAEVAKV LASGNWTPES PSPACQCSRP
1350
1351
GARRLLPDCP AAAGGPPPPQ AVTGSGEVVQ NLTGRNLSDF LVKTYPRLVR
1400
1401
QGLKTKKWVN EVRYGGFSLG GRDPGLPSGQ ELGRSVEELW ALLSPLPGGA
1450
1451
LDRVLKNLTA WAHSLDAQDS LKIWFNNKGW HSMVAFVNRA SNAILRAHLP
1500
1501
PGPARHAHSI TTLNHPLNLT KEQLSEGALM ASSVDVLVSI CVVFAMSFVP
1550
1551
ASFTLVLIEE RVTRAKHLQL MGGLSPTLYW LGNFLWDMCN YLVPACIVVL
1600
1601
IFLAFQQRAY VAPANLPALL LLLLLYGWSI TPLMYPASFF FSVPSTAYVV
1650
1651
LTCINLFIGI NGSMATFVLE LFSDQKLQEV SRILKQVFLI FPHFCLGRGL
1700
1701
IDMVRNQAMA DAFERLGDRQ FQSPLRWEVV GKNLLAMVIQ GPLFLLFTLL
1750
1751
LQHRSQLLPQ PRVRSLPLLG EEDEDVARER ERVVQGATQG DVLVLRNLTK
1800
1801
VYRGQRMPAV DRLCLGIPPG ECFGLLGVNG AGKTSTFRMV TGDTLASRGE
1850
1851
AVLAGHSVAR EPSAAHLSMG YCPQSDAIFE LLTGREHLEL LARLRGVPEA
1900
1901
QVAQTAGSGL ARLGLSWYAD RPAGTYSGGN KRKLATALAL VGDPAVVFLD
1950
1951
EPTTGMDPSA RRFLWNSLLA VVREGRSVML TSHSMEECEA LCSRLAIMVN
2000
2001
GRFRCLGSPQ HLKGRFAAGH TLTLRVPAAR SQPAAAFVAA EFPGAELREA
2050
2051
HGGRLRFQLP PGGRCALARV FGELAVHGAE HGVEDFSVSQ TMLEEVFLYF
2100
2101
SKDQGKDEDT EEQKEAGVGV DPAPGLQHPK RVSQFLDDPS TAETVL    
2146
 

Show the unformatted sequence.

Checksums:
CRC64:6EA624088E74FEE6
MD5:e8df3bc3a4f77d2d4fbb4baa3d2da8f5

TreeFam

Below is a phylogenetic tree of animal genes, with ortholog and paralog assignments, from TreeFam.