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0  structures 1  species 0  interactions 1  sequence 1  architecture

Protein: TAGAP_HUMAN (Q8N103)

Summary

This is the summary of UniProt entry TAGAP_HUMAN (Q8N103).

Description: T-cell activation Rho GTPase-activating protein
Source organism: Homo sapiens (Human) (NCBI taxonomy ID 9606)
Length: 731 amino acids
Reference Proteome: ✓

Please note: when we start each new Pfam data release, we take a copy of the UniProt sequence database. This snapshot of UniProt forms the basis of the overview that you see here. It is important to note that, although some UniProt entries may be removed after a Pfam release, these entries will not be removed from Pfam until the next Pfam data release.

Pfam domains

Download the data used to generate the domain graphic in JSON format.

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Source Domain Start End
disorder n/a 8 9
Pfam RhoGAP 101 246
disorder n/a 193 194
low_complexity n/a 200 212
low_complexity n/a 206 218
disorder n/a 287 431
low_complexity n/a 319 329
low_complexity n/a 414 430
disorder n/a 433 434
disorder n/a 436 444
low_complexity n/a 461 480
disorder n/a 466 510
disorder n/a 524 558
disorder n/a 561 570
disorder n/a 581 621
disorder n/a 633 698
low_complexity n/a 633 639

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Sequence information

This is the amino acid sequence of the UniProt sequence database entry with the accession Q8N103. This sequence is stored in the Pfam database and updated with each new Pfam release, but this means that the sequence we store may differ from that stored by UniProt.

Sequence:
1
MKLRSSHNAS KTLNANNMET LIECQSEGDI KEHPLLASCE SEDSICQLIE
50
51
VKKRKKVLSW PFLMRRLSPA SDFSGALETD LKASLFDQPL SIICGDSDTL
100
101
PRPIQDILTI LCLKGPSTEG IFRRAANEKA RKELKEELNS GDAVDLERLP
150
151
VHLLAVVFKD FLRSIPRKLL SSDLFEEWMG ALEMQDEEDR IEALKQVADK
200
201
LPRPNLLLLK HLVYVLHLIS KNSEVNRMDS SNLAICIGPN MLTLENDQSL
250
251
SFEAQKDLNN KVKTLVEFLI DNCFEIFGEN IPVHSSITSD DSLEHTDSSD
300
301
VSTLQNDSAY DSNDPDVESN SSSGISSPSR QPQVPMATAA GLDSAGPQDA
350
351
REVSPEPIVS TVARLKSSLA QPDRRYSEPS MPSSQECLES RVTNQTLTKS
400
401
EGDFPVPRVG SRLESEEAED PFPEEVFPAV QGKTKRPVDL KIKNLAPGSV
450
451
LPRALVLKAF SSSSLDASSD SSPVASPSSP KRNFFSRHQS FTTKTEKGKP
500
501
SREIKKHSMS FTFAPHKKVL TKNLSAGSGK SQDFTRDHVP RGVRKESQLA
550
551
GRIVQENGCE THNQTARGFC LRPHALSVDD VFQGADWERP GSPPSYEEAM
600
601
QGPAARLVAS ESQTVGSMTV GSMRARMLEA HCLLPPLPPA HHVEDSRHRG
650
651
SKEPLPGHGL SPLPERWKQS RTVHASGDSL GHVSGPGRPE LLPLRTVSES
700
701
VQRNKRDCLV RRCSQPVFEA DQFQYAKESY I                    
731
 

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Checksums:
CRC64:9D8768258A0A681E
MD5:8efc809c5ae172c5f294258d447737d7

TreeFam

Below is a phylogenetic tree of animal genes, with ortholog and paralog assignments, from TreeFam.

AlphaFold Structure Prediction

The protein structure below has been predicted by DeepMind with AlphaFold. For more information, please visit the AlphaFold page for this protein.

Model confidence scale

  Very High (pLDDT > 90)
  Confident (90 > pLDDT > 70)
  Low (70 > pLDDT > 50)
  Very Low (pLDDT < 50)
Highly accurate protein structure prediction with AlphaFold. John Jumper, Richard Evans, Alexander Pritzel, Tim Green, Michael Figurnov, Olaf Ronneberger, Kathryn Tunyasuvunakool, Russ Bates, Augustin Žídek, Anna Potapenko, Alex Bridgland, Clemens Meyer, Simon A. A. Kohl, Andrew J. Ballard, Andrew Cowie, Bernardino Romera-Paredes, Stanislav Nikolov, Rishub Jain, Jonas Adler, Trevor Back, Stig Petersen, David Reiman, Ellen Clancy, Michal Zielinski, Martin Steinegger, Michalina Pacholska, Tamas Berghammer, Sebastian Bodenstein, David Silver, Oriol Vinyals, Andrew W. Senior, Koray Kavukcuoglu, Pushmeet Kohli & Demis Hassabis Nature 2021-07-15; DOI: 10.1038/s41586-021-03819-2;