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4  structures 1  species 0  interactions 1  sequence 1  architecture

Protein: LRC47_HUMAN (Q8N1G4)

Summary

This is the summary of UniProt entry LRC47_HUMAN (Q8N1G4).

Description: Leucine-rich repeat-containing protein 47
Source organism: Homo sapiens (Human) (NCBI taxonomy ID 9606)
Length: 583 amino acids
Reference Proteome: ✓

Please note: when we start each new Pfam data release, we take a copy of the UniProt sequence database. This snapshot of UniProt forms the basis of the overview that you see here. It is important to note that, although some UniProt entries may be removed after a Pfam release, these entries will not be removed from Pfam until the next Pfam data release.

Pfam domains

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Source Domain Start End
low_complexity n/a 11 34
disorder n/a 21 22
disorder n/a 26 30
disorder n/a 33 35
low_complexity n/a 87 99
Pfam LRR_4 99 150
disorder n/a 114 135
Pfam LRR_1 154 175
Pfam LRR_1 203 224
low_complexity n/a 259 305
disorder n/a 265 300
disorder n/a 323 324
Pfam B3_4 332 501
disorder n/a 352 354
disorder n/a 367 368
coiled_coil n/a 402 433
disorder n/a 418 420
disorder n/a 423 427
disorder n/a 465 467
disorder n/a 511 544

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Sequence information

This is the amino acid sequence of the UniProt sequence database entry with the accession Q8N1G4. This sequence is stored in the Pfam database and updated with each new Pfam release, but this means that the sequence we store may differ from that stored by UniProt.

Sequence:
1
MAAAAVSESW PELELAERER RRELLLTGPG LEERVRAAGG QLPPRLFTLP
50
51
LLHYLEVSGC GSLRAPGPGL AQGLPQLHSL VLRRNALGPG LSPELGPLPA
100
101
LRVLDLSGNA LEALPPGQGL GPAEPPGLPQ LQSLNLSGNR LRELPADLAR
150
151
CAPRLQSLNL TGNCLDSFPA ELFRPGALPL LSELAAADNC LRELSPDIAH
200
201
LASLKTLDLS NNQLSEIPAE LADCPKLKEI NFRGNKLRDK RLEKMVSGCQ
250
251
TRSILEYLRV GGRGGGKGKG RAEGSEKEES RRKRRERKQR REGGDGEEQD
300
301
VGDAGRLLLR VLHVSENPVP LTVRVSPEVR DVRPYIVGAV VRGMDLQPGN
350
351
ALKRFLTSQT KLHEDLCEKR TAATLATHEL RAVKGPLLYC ARPPQDLKIV
400
401
PLGRKEAKAK ELVRQLQLEA EEQRKQKKRQ SVSGLHRYLH LLDGNENYPC
450
451
LVDADGDVIS FPPITNSEKT KVKKTTSDLF LEVTSATSLQ ICKDVMDALI
500
501
LKMAEMKKYT LENKEEGSLS DTEADAVSGQ LPDPTTNPSA GKDGPSLLVV
550
551
EQVRVVDLEG SLKVVYPSKA DLATAPPHVT VVR                  
583
 

Show the unformatted sequence.

Checksums:
CRC64:BCCFAE89BCD46031
MD5:b4c62eae33921a5d0e89dd9ec362a77a

Structures

For those sequences which have a structure in the Protein DataBank, we use the mapping between UniProt, PDB and Pfam coordinate systems from the PDBe SIFTS project, to allow us to map Pfam domains onto UniProt three-dimensional structures. The table below shows the mapping between Pfam domains, this UniProt entry and a corresponding three dimensional structure.

Pfam family UniProt residues PDB ID PDB chain ID PDB residues View
B3_4 334 - 501 6ZXD k 334 - 501 Show 3D Structure View in InterPro
6ZXE k 334 - 501 Show 3D Structure View in InterPro
6ZXF k 334 - 501 Show 3D Structure View in InterPro
6ZXG k 334 - 501 Show 3D Structure View in InterPro
LRR_1 154 - 175 6ZXD k 154 - 175 Show 3D Structure View in InterPro
6ZXE k 154 - 175 Show 3D Structure View in InterPro
6ZXF k 154 - 175 Show 3D Structure View in InterPro
6ZXG k 154 - 175 Show 3D Structure View in InterPro
203 - 224 6ZXD k 203 - 224 Show 3D Structure View in InterPro
6ZXE k 203 - 224 Show 3D Structure View in InterPro
6ZXF k 203 - 224 Show 3D Structure View in InterPro
6ZXG k 203 - 224 Show 3D Structure View in InterPro
LRR_4 99 - 150 6ZXD k 99 - 150 Show 3D Structure View in InterPro
6ZXE k 99 - 150 Show 3D Structure View in InterPro
6ZXF k 99 - 150 Show 3D Structure View in InterPro
6ZXG k 99 - 150 Show 3D Structure View in InterPro
×

The parts of the structure corresponding to the Pfam family are highlighted in blue.

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TreeFam

Below is a phylogenetic tree of animal genes, with ortholog and paralog assignments, from TreeFam.

AlphaFold Structure Prediction

The protein structure below has been predicted by DeepMind with AlphaFold. For more information, please visit the AlphaFold page for this protein.

Model confidence scale

  Very High (pLDDT > 90)
  Confident (90 > pLDDT > 70)
  Low (70 > pLDDT > 50)
  Very Low (pLDDT < 50)
Highly accurate protein structure prediction with AlphaFold. John Jumper, Richard Evans, Alexander Pritzel, Tim Green, Michael Figurnov, Olaf Ronneberger, Kathryn Tunyasuvunakool, Russ Bates, Augustin Žídek, Anna Potapenko, Alex Bridgland, Clemens Meyer, Simon A. A. Kohl, Andrew J. Ballard, Andrew Cowie, Bernardino Romera-Paredes, Stanislav Nikolov, Rishub Jain, Jonas Adler, Trevor Back, Stig Petersen, David Reiman, Ellen Clancy, Michal Zielinski, Martin Steinegger, Michalina Pacholska, Tamas Berghammer, Sebastian Bodenstein, David Silver, Oriol Vinyals, Andrew W. Senior, Koray Kavukcuoglu, Pushmeet Kohli & Demis Hassabis Nature 2021-07-15; DOI: 10.1038/s41586-021-03819-2;