Summary
This is the summary of UniProt entry LARG2_HUMAN (Q8N3Y3).
| Description: | LARGE xylosyl- and glucuronyltransferase 2 {ECO:0000312|HGNC:HGNC:16522} Xylosyltransferase LARGE2 {ECO:0000305} Beta-1,3-glucuronyltransferase LARGE2 {ECO:0000305} EC=2.4.-.- EC=2.4.2.- EC=2.4.1.- |
| Source organism: |
Homo sapiens (Human)
(NCBI taxonomy ID
9606)
|
| Length: | 721 amino acids |
| Reference Proteome: |
|
Please note: when we start each new Pfam data release, we take a copy of the UniProt sequence database. This snapshot of UniProt forms the basis of the overview that you see here. It is important to note that, although some UniProt entries may be removed after a Pfam release, these entries will not be removed from Pfam until the next Pfam data release.
Pfam domains
Download the data used to generate the domain graphic in JSON format.
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| Source | Domain | Start | End |
|---|---|---|---|
| disorder | n/a | 1 | 2 |
| sig_p | n/a | 1 | 28 |
| low_complexity | n/a | 9 | 32 |
| low_complexity | n/a | 32 | 47 |
| disorder | n/a | 44 | 50 |
| disorder | n/a | 59 | 89 |
| low_complexity | n/a | 65 | 78 |
| low_complexity | n/a | 86 | 92 |
| Pfam | Glyco_transf_8 | 101 | 346 |
| low_complexity | n/a | 386 | 400 |
| disorder | n/a | 388 | 391 |
| low_complexity | n/a | 421 | 430 |
| disorder | n/a | 430 | 431 |
| Pfam | Glyco_transf_49 | 431 | 498 |
| Pfam | Glyco_transf_49 | 482 | 695 |
| disorder | n/a | 719 | 721 |
Show or hide domain scores.
Sequence information
This is the amino acid sequence of the UniProt sequence database entry with the accession Q8N3Y3. This sequence is stored in the Pfam database and updated with each new Pfam release, but this means that the sequence we store may differ from that stored by UniProt.
| Sequence: | 1
MLPRGRPRAL GAAALLLLLL LLGFLLFGGD LGCERREPGG RAGAPGCFPG
50 51
PLMPRVPPDG RLRRAAALDG DPGAGPGDHN RSDCGPQPPP PPKCELLHVA
100 101
IVCAGHNSSR DVITLVKSML FYRKNPLHLH LVTDAVARNI LETLFHTWMV
150 151
PAVRVSFYHA DQLKPQVSWI PNKHYSGLYG LMKLVLPSAL PAELARVIVL
200 201
DTDVTFASDI SELWALFAHF SDTQAIGLVE NQSDWYLGNL WKNHRPWPAL
250 251
GRGFNTGVIL LRLDRLRQAG WEQMWRLTAR RELLSLPATS LADQDIFNAV
300 301
IKEHPGLVQR LPCVWNVQLS DHTLAERCYS EASDLKVIHW NSPKKLRVKN
350 351
KHVEFFRNFY LTFLEYDGNL LRRELFVCPS QPPPGAEQLQ QALAQLDEED
400 401
PCFEFRQQQL TVHRVHVTFL PHEPPPPRPH DVTLVAQLSM DRLQMLEALC
450 451
RHWPGPMSLA LYLTDAEAQQ FLHFVEASPV LAARQDVAYH VVYREGPLYP
500 501
VNQLRNVALA QALTPYVFLS DIDFLPAYSL YDYLRASIEQ LGLGSRRKAA
550 551
LVVPAFETLR YRFSFPHSKV ELLALLDAGT LYTFRYHEWP RGHAPTDYAR
600 601
WREAQAPYRV QWAANYEPYV VVPRDCPRYD PRFVGFGWNK VAHIVELDAQ
650 651
EYELLVLPEA FTIHLPHAPS LDISRFRSSP TYRDCLQALK DEFHQDLSRH
700 701
HGAAALKYLP ALQQPQSPAR G
721
Show the unformatted sequence. |
| Checksums: |
CRC64:7E9E208AAD872344
MD5:ca94e6b8dbc78aec081fa7d3295fb69d
|
TreeFam
Below is a phylogenetic tree of animal genes, with ortholog and paralog assignments, from TreeFam.
AlphaFold Structure Prediction
The protein structure below has been predicted by DeepMind with AlphaFold. For more information, please visit the AlphaFold page for this protein.
Model confidence scale
| Very High (pLDDT > 90) | |
| Confident (90 > pLDDT > 70) | |
| Low (70 > pLDDT > 50) | |
| Very Low (pLDDT < 50) |
