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5  structures 1  species 0  interactions 1  sequence 1  architecture

Protein: MLKL_HUMAN (Q8NB16)

Summary

This is the summary of UniProt entry MLKL_HUMAN (Q8NB16).

Description: Mixed lineage kinase domain-like protein
Source organism: Homo sapiens (Human) (NCBI taxonomy ID 9606)
Length: 471 amino acids
Reference Proteome: ✓

Please note: when we start each new Pfam data release, we take a copy of the UniProt sequence database. This snapshot of UniProt forms the basis of the overview that you see here. It is important to note that, although some UniProt entries may be removed after a Pfam release, these entries will not be removed from Pfam until the next Pfam data release.

Pfam domains

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Source Domain Start End
disorder n/a 50 53
disorder n/a 55 57
coiled_coil n/a 55 82
disorder n/a 127 139
low_complexity n/a 133 146
disorder n/a 144 150
coiled_coil n/a 148 175
Pfam PK_Tyr_Ser-Thr 209 466
disorder n/a 361 365
disorder n/a 372 373

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Sequence information

This is the amino acid sequence of the UniProt sequence database entry with the accession Q8NB16. This sequence is stored in the Pfam database and updated with each new Pfam release, but this means that the sequence we store may differ from that stored by UniProt.

Sequence:
1
MENLKHIITL GQVIHKRCEE MKYCKKQCRR LGHRVLGLIK PLEMLQDQGK
50
51
RSVPSEKLTT AMNRFKAALE EANGEIEKFS NRSNICRFLT ASQDKILFKD
100
101
VNRKLSDVWK ELSLLLQVEQ RMPVSPISQG ASWAQEDQQD ADEDRRAFQM
150
151
LRRDNEKIEA SLRRLEINMK EIKETLRQYL PPKCMQEIPQ EQIKEIKKEQ
200
201
LSGSPWILLR ENEVSTLYKG EYHRAPVAIK VFKKLQAGSI AIVRQTFNKE
250
251
IKTMKKFESP NILRIFGICI DETVTPPQFS IVMEYCELGT LRELLDREKD
300
301
LTLGKRMVLV LGAARGLYRL HHSEAPELHG KIRSSNFLVT QGYQVKLAGF
350
351
ELRKTQTSMS LGTTREKTDR VKSTAYLSPQ ELEDVFYQYD VKSEIYSFGI
400
401
VLWEIATGDI PFQGCNSEKI RKLVAVKRQQ EPLGEDCPSE LREIIDECRA
450
451
HDPSVRPSVD EILKKLSTFS K                               
471
 

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Checksums:
CRC64:005E7F7AB6D20649
MD5:f9d38934d879613a5f25a0145c6da6c1

Structures

For those sequences which have a structure in the Protein DataBank, we use the mapping between UniProt, PDB and Pfam coordinate systems from the PDBe SIFTS project, to allow us to map Pfam domains onto UniProt three-dimensional structures. The table below shows the mapping between Pfam domains, this UniProt entry and a corresponding three dimensional structure.

Pfam family UniProt residues PDB ID PDB chain ID PDB residues View
PK_Tyr_Ser-Thr 209 - 466 4M67 A 209 - 466 Jmol OpenAstexViewer
4MWI A 209 - 466 Jmol OpenAstexViewer
5KNJ A 209 - 466 Jmol OpenAstexViewer
B 209 - 466 Jmol OpenAstexViewer
5KO1 A 209 - 466 Jmol OpenAstexViewer
6BWK A 209 - 466 Jmol OpenAstexViewer

TreeFam

Below is a phylogenetic tree of animal genes, with ortholog and paralog assignments, from TreeFam.