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3  structures 1  species 0  interactions 1  sequence 1  architecture

Protein: MSPD2_HUMAN (Q8NHP6)

Summary

This is the summary of UniProt entry MSPD2_HUMAN (Q8NHP6).

Description: Motile sperm domain-containing protein 2
Source organism: Homo sapiens (Human) (NCBI taxonomy ID 9606)
Length: 518 amino acids
Reference Proteome: ✓

Please note: when we start each new Pfam data release, we take a copy of the UniProt sequence database. This snapshot of UniProt forms the basis of the overview that you see here. It is important to note that, although some UniProt entries may be removed after a Pfam release, these entries will not be removed from Pfam until the next Pfam data release.

Pfam domains

Download the data used to generate the domain graphic in JSON format.

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Source Domain Start End
Pfam CRAL_TRIO 90 233
disorder n/a 252 253
disorder n/a 255 310
Pfam Motile_Sperm 327 432
disorder n/a 372 378
disorder n/a 383 386
disorder n/a 456 458
transmembrane n/a 493 517
low_complexity n/a 497 506

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Sequence information

This is the amino acid sequence of the UniProt sequence database entry with the accession Q8NHP6. This sequence is stored in the Pfam database and updated with each new Pfam release, but this means that the sequence we store may differ from that stored by UniProt.

Sequence:
1
MAENHAQNKA KLISETRRRF EAEYVTDKSD KYDARDVERL QQDDNWVESY
50
51
LSWRHNIVDE TLKMLDESFQ WRKEISVNDL NESSIPRWLL EIGVIYLHGY
100
101
DKEGNKLFWI RVKYHVKDQK TILDKKKLIA FWLERYAKRE NGKPVTVMFD
150
151
LSETGINSID MDFVRFIINC FKVYYPKYLS KIVIFDMPWL MNAAFKIVKT
200
201
WLGPEAVSLL KFTSKNEVQD YVSVEYLPPH MGGTDPFKYS YPPLVDDDFQ
250
251
TPLCENGPIT SEDETSSKED IESDGKETLE TISNEEQTPL LKKINPTEST
300
301
SKAEENEKVD SKVKAFKKPL SVFKGPLLHI SPAEELYFGS TESGEKKTLI
350
351
VLTNVTKNIV AFKVRTTAPE KYRVKPSNSS CDPGASVDIV VSPHGGLTVS
400
401
AQDRFLIMAA EMEQSSGTGP AELTQFWKEV PRNKVMEHRL RCHTVESSKP
450
451
NTLTLKDNAF NMSDKTSEDI CLQLSRLLES NRKLEDQVQR CIWFQQLLLS
500
501
LTMLLLAFVT SFFYLLYS                                   
518
 

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Checksums:
CRC64:6CC5920CF3B251E2
MD5:bffe8e15876792b2f4df8e3d4f4b5984

Structures

For those sequences which have a structure in the Protein DataBank, we use the mapping between UniProt, PDB and Pfam coordinate systems from the PDBe SIFTS project, to allow us to map Pfam domains onto UniProt three-dimensional structures. The table below shows the mapping between Pfam domains, this UniProt entry and a corresponding three dimensional structure.

Pfam family UniProt residues PDB ID PDB chain ID PDB residues View
Motile_Sperm 327 - 432 6TQS A 327 - 432 Show 3D Structure View in InterPro
B 327 - 432 Show 3D Structure View in InterPro
C 327 - 432 Show 3D Structure View in InterPro
D 327 - 432 Show 3D Structure View in InterPro
E 327 - 432 Show 3D Structure View in InterPro
F 327 - 432 Show 3D Structure View in InterPro
6TQT A 327 - 432 Show 3D Structure View in InterPro
6TQU A 327 - 432 Show 3D Structure View in InterPro
B 327 - 432 Show 3D Structure View in InterPro
×

The parts of the structure corresponding to the Pfam family are highlighted in blue.

Loading Structure Data

TreeFam

Below is a phylogenetic tree of animal genes, with ortholog and paralog assignments, from TreeFam.

AlphaFold Structure Prediction

The protein structure below has been predicted by DeepMind with AlphaFold. For more information, please visit the AlphaFold page for this protein.

Model confidence scale

  Very High (pLDDT > 90)
  Confident (90 > pLDDT > 70)
  Low (70 > pLDDT > 50)
  Very Low (pLDDT < 50)
Highly accurate protein structure prediction with AlphaFold. John Jumper, Richard Evans, Alexander Pritzel, Tim Green, Michael Figurnov, Olaf Ronneberger, Kathryn Tunyasuvunakool, Russ Bates, Augustin Žídek, Anna Potapenko, Alex Bridgland, Clemens Meyer, Simon A. A. Kohl, Andrew J. Ballard, Andrew Cowie, Bernardino Romera-Paredes, Stanislav Nikolov, Rishub Jain, Jonas Adler, Trevor Back, Stig Petersen, David Reiman, Ellen Clancy, Michal Zielinski, Martin Steinegger, Michalina Pacholska, Tamas Berghammer, Sebastian Bodenstein, David Silver, Oriol Vinyals, Andrew W. Senior, Koray Kavukcuoglu, Pushmeet Kohli & Demis Hassabis Nature 2021-07-15; DOI: 10.1038/s41586-021-03819-2;