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1  structure 1  species 0  interactions 1  sequence 1  architecture

Protein: PI42C_HUMAN (Q8TBX8)

Summary

This is the summary of UniProt entry PI42C_HUMAN (Q8TBX8).

Description: Phosphatidylinositol 5-phosphate 4-kinase type-2 gamma EC=2.7.1.149
Source organism: Homo sapiens (Human) (NCBI taxonomy ID 9606)
Length: 421 amino acids
Reference Proteome: ✓

Please note: when we start each new Pfam data release, we take a copy of the UniProt sequence database. This snapshot of UniProt forms the basis of the overview that you see here. It is important to note that, although some UniProt entries may be removed after a Pfam release, these entries will not be removed from Pfam until the next Pfam data release.

Pfam domains

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Source Domain Start End
low_complexity n/a 1 20
disorder n/a 8 10
low_complexity n/a 12 24
low_complexity n/a 26 40
Pfam PIP5K 128 419
disorder n/a 128 129
low_complexity n/a 255 266
low_complexity n/a 293 308
disorder n/a 295 311
low_complexity n/a 380 397

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Sequence information

This is the amino acid sequence of the UniProt sequence database entry with the accession Q8TBX8. This sequence is stored in the Pfam database and updated with each new Pfam release, but this means that the sequence we store may differ from that stored by UniProt.

Sequence:
1
MASSSVPPAT VSAATAGPGP GFGFASKTKK KHFVQQKVKV FRAADPLVGV
50
51
FLWGVAHSIN ELSQVPPPVM LLPDDFKASS KIKVNNHLFH RENLPSHFKF
100
101
KEYCPQVFRN LRDRFGIDDQ DYLVSLTRNP PSESEGSDGR FLISYDRTLV
150
151
IKEVSSEDIA DMHSNLSNYH QYIVKCHGNT LLPQFLGMYR VSVDNEDSYM
200
201
LVMRNMFSHR LPVHRKYDLK GSLVSREASD KEKVKELPTL KDMDFLNKNQ
250
251
KVYIGEEEKK IFLEKLKRDV EFLVQLKIMD YSLLLGIHDI IRGSEPEEEA
300
301
PVREDESEVD GDCSLTGPPA LVGSYGTSPE GIGGYIHSHR PLGPGEFESF
350
351
IDVYAIRSAE GAPQKEVYFM GLIDILTQYD AKKKAAHAAK TVKHGAGAEI
400
401
STVHPEQYAK RFLDFITNIF A                               
421
 

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Checksums:
CRC64:65D1CBCF0826D476
MD5:f15a59b73b5223e67fe6af605e0033f1

Structures

For those sequences which have a structure in the Protein DataBank, we use the mapping between UniProt, PDB and Pfam coordinate systems from the PDBe SIFTS project, to allow us to map Pfam domains onto UniProt three-dimensional structures. The table below shows the mapping between Pfam domains, this UniProt entry and a corresponding three dimensional structure.

Pfam family UniProt residues PDB ID PDB chain ID PDB residues View
PIP5K 128 - 417 2GK9 A 128 - 417 Jmol OpenAstexViewer
B 128 - 417 Jmol OpenAstexViewer
C 128 - 417 Jmol OpenAstexViewer
D 128 - 417 Jmol OpenAstexViewer

TreeFam

Below is a phylogenetic tree of animal genes, with ortholog and paralog assignments, from TreeFam.