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1  structure 1  species 0  interactions 1  sequence 1  architecture

Protein: DTX3L_HUMAN (Q8TDB6)

Summary

This is the summary of UniProt entry DTX3L_HUMAN (Q8TDB6).

Description: E3 ubiquitin-protein ligase DTX3L
Source organism: Homo sapiens (Human) (NCBI taxonomy ID 9606)
View Pfam proteome data.
Length: 740 amino acids
Reference Proteome: ✓

Please note: when we start each new Pfam data release, we take a copy of the UniProt sequence database. This snapshot of UniProt forms the basis of the overview that you see here. It is important to note that, although some UniProt entries may be removed after a Pfam release, these entries will not be removed from Pfam until the next Pfam data release.

Pfam domains

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Source Domain Start End
disorder n/a 1 3
disorder n/a 9 14
disorder n/a 16 17
disorder n/a 26 31
disorder n/a 33 50
disorder n/a 52 56
disorder n/a 69 70
disorder n/a 88 89
disorder n/a 96 123
disorder n/a 198 225
disorder n/a 230 231
disorder n/a 469 471
disorder n/a 516 549
Pfam zf-C3HC4_2 560 599
Pfam DTC 607 739
disorder n/a 648 652
disorder n/a 654 661

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Sequence information

This is the amino acid sequence of the UniProt sequence database entry with the accession Q8TDB6. This sequence is stored in the Pfam database and updated with each new Pfam release, but this means that the sequence we store may differ from that stored by UniProt.

Sequence:
1
MASHLRPPSP LLVRVYKSGP RVRRKLESYF QSSKSSGGGE CTVSTQEHEA
50
51
PGTFRVEFSE RAAKERVLKK GEHQILVDEK PVPIFLVPTE NSIKKNTRPQ
100
101
ISSLTQSQAE TPSGDMHQHE GHIPNAVDSC LQKIFLTVTA DLNCNLFSKE
150
151
QRAYITTLCP SIRKMEGHDG IEKVCGDFQD IERIHQFLSE QFLESEQKQQ
200
201
FSPSMTERKP LSQQERDSCI SPSEPETKAE QKSNYFEVPL PYFEYFKYIC
250
251
PDKINSIEKR FGVNIEIQES SPNMVCLDFT SSRSGDLEAA RESFASEFQK
300
301
NTEPLKQECV SLADSKQANK FKQELNHQFT KLLIKEKGGE LTLLGTQDDI
350
351
SAAKQKISEA FVKIPVKLFA ANYMMNVIEV DSAHYKLLET ELLQEISEIE
400
401
KRYDICSKVS EKGQKTCILF ESKDRQVDLS VHAYASFIDA FQHASCQLMR
450
451
EVLLLKSLGK ERKHLHQTKF ADDFRKRHPN VHFVLNQESM TLTGLPNHLA
500
501
KAKQYVLKGG GMSSLAGKKL KEGHETPMDI DSDDSKAASP PLKGSVSSEA
550
551
SELDKKEKGI CVICMDTISN KKVLPKCKHE FCAPCINKAM SYKPICPTCQ
600
601
TSYGIQKGNQ PEGSMVFTVS RDSLPGYESF GTIVITYSMK AGIQTEEHPN
650
651
PGKRYPGIQR TAYLPDNKEG RKVLKLLYRA FDQKLIFTVG YSRVLGVSDV
700
701
ITWNDIHHKT SRFGGPEMYG YPDPSYLKRV KEELKAKGIE           
740
 

Show the unformatted sequence.

Checksums:
CRC64:C413BB744CEE6223
MD5:61b8956020d7082f0fb41ed7eaa945e4

Structures

For those sequences which have a structure in the Protein DataBank, we use the mapping between UniProt, PDB and Pfam coordinate systems from the PDBe SIFTS project, to allow us to map Pfam domains onto UniProt three-dimensional structures. The table below shows the mapping between Pfam domains, this UniProt entry and a corresponding three dimensional structure.

Pfam family UniProt residues PDB ID PDB chain ID PDB residues View
DTC 607 - 739 3PG6 A 607 - 739 Jmol OpenAstexViewer
B 607 - 739 Jmol OpenAstexViewer
C 607 - 739 Jmol OpenAstexViewer
D 607 - 739 Jmol OpenAstexViewer

TreeFam

Below is a phylogenetic tree of animal genes, with ortholog and paralog assignments, from TreeFam.