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3  structures 1  species 0  interactions 1  sequence 1  architecture

Protein: MCLN3_HUMAN (Q8TDD5)

Summary

This is the summary of UniProt entry MCLN3_HUMAN (Q8TDD5).

Description: Mucolipin-3 {ECO:0000303|PubMed:19497048}
Source organism: Homo sapiens (Human) (NCBI taxonomy ID 9606)
Length: 553 amino acids
Reference Proteome: ✓

Please note: when we start each new Pfam data release, we take a copy of the UniProt sequence database. This snapshot of UniProt forms the basis of the overview that you see here. It is important to note that, although some UniProt entries may be removed after a Pfam release, these entries will not be removed from Pfam until the next Pfam data release.

Pfam domains

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Source Domain Start End
low_complexity n/a 4 16
disorder n/a 19 22
transmembrane n/a 63 82
transmembrane n/a 287 308
transmembrane n/a 340 358
low_complexity n/a 342 356
Pfam PKD_channel 363 508
transmembrane n/a 370 392
transmembrane n/a 412 434
transmembrane n/a 480 501

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Sequence information

This is the amino acid sequence of the UniProt sequence database entry with the accession Q8TDD5. This sequence is stored in the Pfam database and updated with each new Pfam release, but this means that the sequence we store may differ from that stored by UniProt.

Sequence:
1
MADPEVVVSS CSSHEEENRC NFNQQTSPSE ELLLEDQMRR KLKFFFMNPC
50
51
EKFWARGRKP WKLAIQILKI AMVTIQLVLF GLSNQMVVAF KEENTIAFKH
100
101
LFLKGYMDRM DDTYAVYTQS DVYDQLIFAV NQYLQLYNVS VGNHAYENKG
150
151
TKQSAMAICQ HFYKRGNIYP GNDTFDIDPE IETECFFVEP DEPFHIGTPA
200
201
ENKLNLTLDF HRLLTVELQF KLKAINLQTV RHQELPDCYD FTLTITFDNK
250
251
AHSGRIKISL DNDISIRECK DWHVSGSIQK NTHYMMIFDA FVILTCLVSL
300
301
ILCIRSVIRG LQLQQEFVNF FLLHYKKEVS VSDQMEFVNG WYIMIIISDI
350
351
LTIIGSILKM EIQAKSLTSY DVCSILLGTS TMLVWLGVIR YLGFFAKYNL
400
401
LILTLQAALP NVIRFCCCAA MIYLGYCFCG WIVLGPYHDK FRSLNMVSEC
450
451
LFSLINGDDM FATFAKMQQK SYLVWLFSRI YLYSFISLFI YMILSLFIAL
500
501
ITDTYETIKQ YQQDGFPETE LRTFISECKD LPNSGKYRLE DDPPVSLFCC
550
551
CKK                                                   
553
 

Show the unformatted sequence.

Checksums:
CRC64:2E63DA196379F9E3
MD5:46f42dc6056caf215273999a26a7ee43

Structures

For those sequences which have a structure in the Protein DataBank, we use the mapping between UniProt, PDB and Pfam coordinate systems from the PDBe SIFTS project, to allow us to map Pfam domains onto UniProt three-dimensional structures. The table below shows the mapping between Pfam domains, this UniProt entry and a corresponding three dimensional structure.

Pfam family UniProt residues PDB ID PDB chain ID PDB residues View
PKD_channel 363 - 508 6AYE A 363 - 508 Jmol OpenAstexViewer
B 363 - 508 Jmol OpenAstexViewer
C 363 - 508 Jmol OpenAstexViewer
D 363 - 508 Jmol OpenAstexViewer
6AYF A 363 - 508 Jmol OpenAstexViewer
B 363 - 508 Jmol OpenAstexViewer
C 363 - 508 Jmol OpenAstexViewer
D 363 - 508 Jmol OpenAstexViewer
6AYG A 363 - 508 Jmol OpenAstexViewer
B 363 - 508 Jmol OpenAstexViewer
C 363 - 508 Jmol OpenAstexViewer
D 363 - 508 Jmol OpenAstexViewer

TreeFam

Below is a phylogenetic tree of animal genes, with ortholog and paralog assignments, from TreeFam.