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0  structures 1  species 0  interactions 1  sequence 1  architecture

Protein: ARH40_HUMAN (Q8TER5)

Summary

This is the summary of UniProt entry ARH40_HUMAN (Q8TER5).

Description: Rho guanine nucleotide exchange factor 40
Source organism: Homo sapiens (Human) (NCBI taxonomy ID 9606)
Length: 1519 amino acids
Reference Proteome: ✓

Please note: when we start each new Pfam data release, we take a copy of the UniProt sequence database. This snapshot of UniProt forms the basis of the overview that you see here. It is important to note that, although some UniProt entries may be removed after a Pfam release, these entries will not be removed from Pfam until the next Pfam data release.

Pfam domains

Download the data used to generate the domain graphic in JSON format.

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Source Domain Start End
disorder n/a 193 520
low_complexity n/a 197 222
low_complexity n/a 273 287
low_complexity n/a 313 340
low_complexity n/a 348 369
low_complexity n/a 363 394
disorder n/a 522 523
disorder n/a 547 571
low_complexity n/a 553 562
low_complexity n/a 590 611
disorder n/a 605 608
disorder n/a 655 664
low_complexity n/a 696 711
disorder n/a 698 719
disorder n/a 724 726
disorder n/a 742 746
disorder n/a 750 757
low_complexity n/a 777 793
disorder n/a 807 810
coiled_coil n/a 828 848
low_complexity n/a 831 845
low_complexity n/a 898 910
disorder n/a 903 907
disorder n/a 919 923
disorder n/a 951 1040
low_complexity n/a 959 977
low_complexity n/a 980 1004
low_complexity n/a 1016 1033
disorder n/a 1046 1048
disorder n/a 1053 1079
disorder n/a 1081 1083
Pfam RhoGEF 1089 1248
low_complexity n/a 1103 1118
disorder n/a 1105 1121
low_complexity n/a 1123 1134
low_complexity n/a 1215 1223
low_complexity n/a 1404 1420
low_complexity n/a 1413 1425
disorder n/a 1435 1436
disorder n/a 1438 1441
disorder n/a 1464 1519

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Sequence information

This is the amino acid sequence of the UniProt sequence database entry with the accession Q8TER5. This sequence is stored in the Pfam database and updated with each new Pfam release, but this means that the sequence we store may differ from that stored by UniProt.

Sequence:
1
MEPEPVEDCV QSTLAALYPP FEATAPTLLG QVFQVVERTY REDALRYTLD
50
51
FLVPAKHLLA KVQQEACAQY SGFLFFHEGW PLCLHEQVVV QLAALPWQLL
100
101
RPGDFYLQVV PSAAQAPRLA LKCLAPGGGR VQEVPVPNEA CAYLFTPEWL
150
151
QGINKDRPTG RLSTCLLSAP SGIQRLPWAE LICPRFVHKE GLMVGHQPST
200
201
LPPELPSGPP GLPSPPLPEE ALGTRSPGDG HNAPVEGPEG EYVELLEVTL
250
251
PVRGSPTDAE GSPGLSRVRT VPTRKGAGGK GRHRRHRAWM HQKGLGPRGQ
300
301
DGARPPGEGS STGASPESPP GAEAVPEAAV LEVSEPPAEA VGEASGSCPL
350
351
RPGELRGGGG GGQGAEGPPG TPRRTGKGNR RKKRAAGRGA LSRGGDSAPL
400
401
SPGDKEDASH QEALGNLPSP SEHKLPECHL VKEEYEGSGK PESEPKELKT
450
451
AGEKEPQLSE ACGPTEEGAG ERELEGPGLL CMAGHTGPEG PLSDTPTPPL
500
501
ETVQEGKGDN IPEEALAVSV SDHPDVAWDL MASGFLILTG GVDQSGRALL
550
551
TITPPCPPEE PPPSRDTLNT TLHYLHSLLR PDLQTLGLSV LLDLRQAPPL
600
601
PPALIPALSQ LQDSGDPPLV QRLLILIHDD LPTELCGFQG AEVLSENDLK
650
651
RVAKPEELQW ELGGHRDPSP SHWVEIHQEV VRLCRLCQGV LGSVRQAIEE
700
701
LEGAAEPEEE EAVGMPKPLQ KVLADPRLTA LQRDGGAILM RLRSTPSSKL
750
751
EGQGPATLYQ EVDEAIHQLV RLSNLHVQQQ EQRQCLRRLQ QVLQWLSGPG
800
801
EEQLASFAMP GDTLSALQET ELRFRAFSAE VQERLAQARE ALALEENATS
850
851
QKVLDIFEQR LEQVESGLHR ALRLQRFFQQ AHEWVDEGFA RLAGAGPGRE
900
901
AVLAALALRR APEPSAGTFQ EMRALALDLG SPAALREWGR CQARCQELER
950
951
RIQQHVGEEA SPRGYRRRRA DGASSGGAQW GPRSPSPSLS SLLLPSSPGP
1000
1001
RPAPSHCSLA PCGEDYEEEG PELAPEAEGR PPRAVLIRGL EVTSTEVVDR
1050
1051
TCSPREHVLL GRARGPDGPW GVGTPRMERK RSISAQQRLV SELIACEQDY
1100
1101
VATLSEPVPP PGPELTPELR GTWAAALSAR ERLRSFHRTH FLRELQGCAT
1150
1151
HPLRIGACFL RHGDQFSLYA QYVKHRHKLE NGLAALSPLS KGSMEAGPYL
1200
1201
PRALQQPLEQ LTRYGRLLEE LLREAGPELS SECRALGAAV QLLREQEARG
1250
1251
RDLLAVEAVR GCEIDLKEQG QLLHRDPFTV ICGRKKCLRH VFLFEHLLLF
1300
1301
SKLKGPEGGS EMFVYKQAFK TADMGLTENI GDSGLCFELW FRRRRAREAY
1350
1351
TLQATSPEIK LKWTSSIAQL LWRQAAHNKE LRVQQMVSMG IGNKPFLDIK
1400
1401
ALGERTLSAL LTGRAARTRA SVAVSSFEHA GPSLPGLSPG ACSLPARVEE
1450
1451
EAWDLDVKQI SLAPETLDSS GDVSPGPRNS PSLQPPHPGS STPTLASRGI
1500
1501
LGLSRQSHAR ALSDPTTPL                                  
1519
 

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Checksums:
CRC64:E59DD53AE399E2E6
MD5:3ba602b8ea0ed571e4f24ae237dfa34e

TreeFam

Below is a phylogenetic tree of animal genes, with ortholog and paralog assignments, from TreeFam.