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0  structures 1  species 0  interactions 1  sequence 1  architecture

Protein: DP2L_METAC (Q8THG5)

Summary

This is the summary of UniProt entry DP2L_METAC (Q8THG5).

Description: DNA polymerase II large subunit {ECO:0000255|HAMAP-Rule:MF_00324}
Source organism: Methanosarcina acetivorans (strain ATCC 35395 / DSM 2834 / JCM 12185 / C2A) (NCBI taxonomy ID 188937)
Length: 1145 amino acids
Reference Proteome: ✓

Please note: when we start each new Pfam data release, we take a copy of the UniProt sequence database. This snapshot of UniProt forms the basis of the overview that you see here. It is important to note that, although some UniProt entries may be removed after a Pfam release, these entries will not be removed from Pfam until the next Pfam data release.

Pfam domains

Download the data used to generate the domain graphic in JSON format.

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Source Domain Start End
disorder n/a 1 2
Pfam PolC_DP2 12 890
coiled_coil n/a 14 34
disorder n/a 28 34
disorder n/a 36 45
coiled_coil n/a 60 80
low_complexity n/a 178 188
disorder n/a 228 235
disorder n/a 287 296
disorder n/a 447 451
disorder n/a 455 456
disorder n/a 590 596

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Sequence information

This is the amino acid sequence of the UniProt sequence database entry with the accession Q8THG5. This sequence is stored in the Pfam database and updated with each new Pfam release, but this means that the sequence we store may differ from that stored by UniProt.

Sequence:
1
MGETIASEEM HEYFDGLEAR LKEAIEIANR ARAQGGDPKP TVEIPLAKDL
50
51
ADRVENLIGV QGVAAKIREL ETRMSREEAA LEIGKQVAEG VVGSFPTKKD
100
101
AVEAAIRVSM ATLTEGVVAA PIEGIDKVEL GKNDDGSQYI RIFYSGPIRS
150
151
AGGTAQALSV LVGDYVRRGI GIDRYKPREE EVERYVEEIL LYKRVASLQY
200
201
TPSEDEIRLI VRNCPVCIDG DPTEEAEVEG HRDLERIGTN RVRGGMCLVL
250
251
AEGLALKAPK VKKHVNKLKM DGWDWLETLI GGAKSGGSAE DEQKSKIKPK
300
301
DKYIRDLIAG RPVFSHPSRP GGFRLRYGRS RNTSFASAGI NPASMVLLDD
350
351
FITNGTQLKV ERPGKAAAMS AVDSIEGPTV RLFSGDLVRI DNIKEAYELR
400
401
PQVESIVDIG EILINYGDFL ENNHPLMPSP YVFEWWQYDY EAACPEKTPE
450
451
EELKNPSSAL ALRLAEEYNV PLHPTFTYLW HDINRNEFEA LRKFVVEKGT
500
501
FDGEGTLKLP LTASFEEGIK PLLEKLLVLH RVKEDKILVE EALPFVLCLG
550
551
LDSSLKEKAG MPDTDDMVEA AGVLSGFKVY PRAPSRIGAR MGRPEKSDLR
600
601
KMSPAAQVLF PINNCGGITR NLVSASDYTS CMNGKIGEIE VELGLRECPA
650
651
CGKETYFWRC ECGEFTNPKL SCPRCKIDVR GAETCPKCGR KPTSVANVKL
700
701
DFRSVYKQAF ENVGEREKMD LIKGVKRLMN GQMTPEPLEK GILRAKHDVY
750
751
IFKDGTVRYD MSDIPLTHIR ADELGITATK LLELGYREDI YGNPLERDDQ
800
801
VVCLKVQDLV ISYDGGEYML RTAKYVDDLL VKYYKVGPYY NAETIQDLVG
850
851
VLLIGLAPHT SAGVLGRLIG FTKASVGYAH PFFHASKRRN CDGDEDCIML
900
901
LMDGILNFSR SYLPDKRGGK MDAPLVLTTR IDPKEVDKEA HNIDVPARYP
950
951
LEFYRATQEI KNPTELESIM DLISGRLGTP EQYEHFMFTH DTSDIAAGPL
1000
1001
NSSYKTLGSM IEKMEAQLSL ANRIRAVDAP DVAERVLKSH FLPDLIGNLR
1050
1051
SFSRQRMRCI KCGEKFRRPP LTGACPKCGG NVVLTVHEGA VRKYLEISKE
1100
1101
IGERYGVSSY TRQRIELLDY DICSLFENHK VKQLGLSDFM SGSAR     
1145
 

Show the unformatted sequence.

Checksums:
CRC64:36C329A400C09E43
MD5:aced53e052768ccc9c46e3283281d7a3

AlphaFold Structure Prediction

The protein structure below has been predicted by DeepMind with AlphaFold. For more information, please visit the AlphaFold page for this protein.

Model confidence scale

  Very High (pLDDT > 90)
  Confident (90 > pLDDT > 70)
  Low (70 > pLDDT > 50)
  Very Low (pLDDT < 50)
Highly accurate protein structure prediction with AlphaFold. John Jumper, Richard Evans, Alexander Pritzel, Tim Green, Michael Figurnov, Olaf Ronneberger, Kathryn Tunyasuvunakool, Russ Bates, Augustin Žídek, Anna Potapenko, Alex Bridgland, Clemens Meyer, Simon A. A. Kohl, Andrew J. Ballard, Andrew Cowie, Bernardino Romera-Paredes, Stanislav Nikolov, Rishub Jain, Jonas Adler, Trevor Back, Stig Petersen, David Reiman, Ellen Clancy, Michal Zielinski, Martin Steinegger, Michalina Pacholska, Tamas Berghammer, Sebastian Bodenstein, David Silver, Oriol Vinyals, Andrew W. Senior, Koray Kavukcuoglu, Pushmeet Kohli & Demis Hassabis Nature 2021-07-15; DOI: 10.1038/s41586-021-03819-2;