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16  structures 1  species 0  interactions 1  sequence 1  architecture

Protein: PDC6I_HUMAN (Q8WUM4)

Summary

This is the summary of UniProt entry PDC6I_HUMAN (Q8WUM4).

Description: Programmed cell death 6-interacting protein
Source organism: Homo sapiens (Human) (NCBI taxonomy ID 9606)
Length: 868 amino acids
Reference Proteome: ✓

Please note: when we start each new Pfam data release, we take a copy of the UniProt sequence database. This snapshot of UniProt forms the basis of the overview that you see here. It is important to note that, although some UniProt entries may be removed after a Pfam release, these entries will not be removed from Pfam until the next Pfam data release.

Pfam domains

Download the data used to generate the domain graphic in JSON format.

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Source Domain Start End
Pfam BRO1 4 378
Pfam ALIX_LYPXL_bnd 412 701
coiled_coil n/a 433 453
low_complexity n/a 448 462
disorder n/a 455 456
disorder n/a 468 473
disorder n/a 483 484
disorder n/a 532 539
low_complexity n/a 548 559
coiled_coil n/a 552 579
disorder n/a 636 644
disorder n/a 647 648
disorder n/a 650 651
disorder n/a 698 807
low_complexity n/a 736 769
low_complexity n/a 778 811
disorder n/a 832 834
disorder n/a 836 868
low_complexity n/a 839 868

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Sequence information

This is the amino acid sequence of the UniProt sequence database entry with the accession Q8WUM4. This sequence is stored in the Pfam database and updated with each new Pfam release, but this means that the sequence we store may differ from that stored by UniProt.

Sequence:
1
MATFISVQLK KTSEVDLAKP LVKFIQQTYP SGGEEQAQYC RAAEELSKLR
50
51
RAAVGRPLDK HEGALETLLR YYDQICSIEP KFPFSENQIC LTFTWKDAFD
100
101
KGSLFGGSVK LALASLGYEK SCVLFNCAAL ASQIAAEQNL DNDEGLKIAA
150
151
KHYQFASGAF LHIKETVLSA LSREPTVDIS PDTVGTLSLI MLAQAQEVFF
200
201
LKATRDKMKD AIIAKLANQA ADYFGDAFKQ CQYKDTLPKE VFPVLAAKHC
250
251
IMQANAEYHQ SILAKQQKKF GEEIARLQHA AELIKTVASR YDEYVNVKDF
300
301
SDKINRALAA AKKDNDFIYH DRVPDLKDLD PIGKATLVKS TPVNVPISQK
350
351
FTDLFEKMVP VSVQQSLAAY NQRKADLVNR SIAQMREATT LANGVLASLN
400
401
LPAAIEDVSG DTVPQSILTK SRSVIEQGGI QTVDQLIKEL PELLQRNREI
450
451
LDESLRLLDE EEATDNDLRA KFKERWQRTP SNELYKPLRA EGTNFRTVLD
500
501
KAVQADGQVK ECYQSHRDTI VLLCKPEPEL NAAIPSANPA KTMQGSEVVN
550
551
VLKSLLSNLD EVKKEREGLE NDLKSVNFDM TSKFLTALAQ DGVINEEALS
600
601
VTELDRVYGG LTTKVQESLK KQEGLLKNIQ VSHQEFSKMK QSNNEANLRE
650
651
EVLKNLATAY DNFVELVANL KEGTKFYNEL TEILVRFQNK CSDIVFARKT
700
701
ERDELLKDLQ QSIAREPSAP SIPTPAYQSS PAGGHAPTPP TPAPRTMPPT
750
751
KPQPPARPPP PVLPANRAPS ATAPSPVGAG TAAPAPSQTP GSAPPPQAQG
800
801
PPYPTYPGYP GYCQMPMPMG YNPYAYGQYN MPYPPVYHQS PGQAPYPGPQ
850
851
QPSYPFPQPP QQSYYPQQ                                   
868
 

Show the unformatted sequence.

Checksums:
CRC64:573588D1F612EC93
MD5:0451e65ef0c82c96792534572721b292

Structures

For those sequences which have a structure in the Protein DataBank, we use the mapping between UniProt, PDB and Pfam coordinate systems from the PDBe SIFTS project, to allow us to map Pfam domains onto UniProt three-dimensional structures. The table below shows the mapping between Pfam domains, this UniProt entry and a corresponding three dimensional structure.

Pfam family UniProt residues PDB ID PDB chain ID PDB residues View
ALIX_LYPXL_bnd 412 - 698 2OEV A 412 - 698 Show 3D Structure View in InterPro
2R02 A 412 - 698 Show 3D Structure View in InterPro
2R03 A 412 - 698 Show 3D Structure View in InterPro
2R05 A 412 - 698 Show 3D Structure View in InterPro
2XS1 A 412 - 698 Show 3D Structure View in InterPro
2XS8 A 412 - 698 Show 3D Structure View in InterPro
412 - 701 2OEX A 412 - 701 Show 3D Structure View in InterPro
B 412 - 701 Show 3D Structure View in InterPro
2OJQ A 412 - 701 Show 3D Structure View in InterPro
4JJY A 412 - 701 Show 3D Structure View in InterPro
B 412 - 701 Show 3D Structure View in InterPro
BRO1 360 - 378 2OJQ A 360 - 378 Show 3D Structure View in InterPro
361 - 378 2OEX A 361 - 378 Show 3D Structure View in InterPro
4JJY A 361 - 378 Show 3D Structure View in InterPro
B 361 - 378 Show 3D Structure View in InterPro
362 - 378 2OEX B 362 - 378 Show 3D Structure View in InterPro
4 - 358 2OEW A 4 - 358 Show 3D Structure View in InterPro
3C3O A 4 - 358 Show 3D Structure View in InterPro
3C3Q A 4 - 358 Show 3D Structure View in InterPro
3C3R A 4 - 358 Show 3D Structure View in InterPro
5V3R A 4 - 358 Show 3D Structure View in InterPro
5WA1 A 4 - 358 Show 3D Structure View in InterPro
6KP3 A 4 - 358 Show 3D Structure View in InterPro
4 - 378 2OEV A 4 - 378 Show 3D Structure View in InterPro
2R02 A 4 - 378 Show 3D Structure View in InterPro
2R03 A 4 - 378 Show 3D Structure View in InterPro
2R05 A 4 - 378 Show 3D Structure View in InterPro
2XS1 A 4 - 378 Show 3D Structure View in InterPro
2XS8 A 4 - 378 Show 3D Structure View in InterPro
×

The parts of the structure corresponding to the Pfam family are highlighted in blue.

Loading Structure Data

TreeFam

Below is a phylogenetic tree of animal genes, with ortholog and paralog assignments, from TreeFam.

AlphaFold Structure Prediction

The protein structure below has been predicted by DeepMind with AlphaFold. For more information, please visit the AlphaFold page for this protein.

Model confidence scale

  Very High (pLDDT > 90)
  Confident (90 > pLDDT > 70)
  Low (70 > pLDDT > 50)
  Very Low (pLDDT < 50)
Highly accurate protein structure prediction with AlphaFold. John Jumper, Richard Evans, Alexander Pritzel, Tim Green, Michael Figurnov, Olaf Ronneberger, Kathryn Tunyasuvunakool, Russ Bates, Augustin Žídek, Anna Potapenko, Alex Bridgland, Clemens Meyer, Simon A. A. Kohl, Andrew J. Ballard, Andrew Cowie, Bernardino Romera-Paredes, Stanislav Nikolov, Rishub Jain, Jonas Adler, Trevor Back, Stig Petersen, David Reiman, Ellen Clancy, Michal Zielinski, Martin Steinegger, Michalina Pacholska, Tamas Berghammer, Sebastian Bodenstein, David Silver, Oriol Vinyals, Andrew W. Senior, Koray Kavukcuoglu, Pushmeet Kohli & Demis Hassabis Nature 2021-07-15; DOI: 10.1038/s41586-021-03819-2;