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0  structures 1  species 0  interactions 1  sequence 1  architecture

Protein: GBF1_HUMAN (Q92538)

Summary

This is the summary of UniProt entry GBF1_HUMAN (Q92538).

Description: Golgi-specific brefeldin A-resistance guanine nucleotide exchange factor 1
Source organism: Homo sapiens (Human) (NCBI taxonomy ID 9606)
Length: 1859 amino acids
Reference Proteome: ✓

Please note: when we start each new Pfam data release, we take a copy of the UniProt sequence database. This snapshot of UniProt forms the basis of the overview that you see here. It is important to note that, although some UniProt entries may be removed after a Pfam release, these entries will not be removed from Pfam until the next Pfam data release.

Pfam domains

Download the data used to generate the domain graphic in JSON format.

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Source Domain Start End
Pfam DCB 23 198
disorder n/a 27 28
disorder n/a 107 110
disorder n/a 207 215
disorder n/a 218 373
low_complexity n/a 275 289
disorder n/a 375 377
disorder n/a 381 384
Pfam Sec7_N 400 551
disorder n/a 596 597
disorder n/a 608 634
disorder n/a 636 640
disorder n/a 642 665
low_complexity n/a 642 654
disorder n/a 669 673
low_complexity n/a 692 704
Pfam Sec7 699 884
disorder n/a 844 846
disorder n/a 1059 1067
disorder n/a 1090 1099
low_complexity n/a 1198 1216
low_complexity n/a 1279 1296
disorder n/a 1284 1310
disorder n/a 1316 1320
disorder n/a 1322 1331
disorder n/a 1333 1335
disorder n/a 1352 1377
low_complexity n/a 1359 1368
disorder n/a 1432 1483
disorder n/a 1524 1525
transmembrane n/a 1627 1647
disorder n/a 1719 1817
low_complexity n/a 1751 1760
low_complexity n/a 1771 1791
low_complexity n/a 1795 1818
disorder n/a 1820 1822
disorder n/a 1828 1832
disorder n/a 1837 1859

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Sequence information

This is the amino acid sequence of the UniProt sequence database entry with the accession Q92538. This sequence is stored in the Pfam database and updated with each new Pfam release, but this means that the sequence we store may differ from that stored by UniProt.

Sequence:
1
MVDKNIYIIQ GEINIVVGAI KRNARWSTHT PLDEERDPLL HSFGHLKEVL
50
51
NSITELSEIE PNVFLRPFLE VIRSEDTTGP ITGLALTSVN KFLSYALIDP
100
101
THEGTAEGME NMADAVTHAR FVGTDPASDE VVLMKILQVL RTLLLTPVGA
150
151
HLTNESVCEI MQSCFRICFE MRLSELLRKS AEHTLVDMVQ LLFTRLPQFK
200
201
EEPKNYVGTN MKKLKMRAGG MSDSSKWKKQ KRSPRPPRHM TKVTPGSELP
250
251
TPNGTTLSSN LTGGMPFIDV PTPISSASSE AASAVVSPST DSGLEFSSQT
300
301
TSKEDLTDLE QPGSPGYSTA TEPGSSELGV PEQPDLQEGT HVEKSQSASV
350
351
ESIPEVLEEC TSPADHSDSA SVHDMDYVNP RGVRFTQSSQ KEGTALVPYG
400
401
LPCIRELFRF LISLTNPHDR HNSEVMIHMG LHLLTVALES APVAQCQTLL
450
451
GLIKDEMCRH LFQLLSIERL NLYAASLRVC FLLFESMREH LKFQMEMYIK
500
501
KLMEIITVEN PKMPYEMKEM ALEAIVQLWR IPSFVTELYI NYDCDYYCSN
550
551
LFEELTKLLS KNAFPVSGQL YTTHLLSLDA LLTVIDSTEA HCQAKVLNSL
600
601
TQQEKKETAR PSCEIVDGTR EASNTERTAS DGKAVGMASD IPGLHLPGGG
650
651
RLPPEHGKSG CSDLEEAVDS GADKKFARKP PRFSCLLPDP RELIEIKNKK
700
701
KLLITGTEQF NQKPKKGIQF LQEKGLLTIP MDNTEVAQWL RENPRLDKKM
750
751
IGEFVSDRKN IDLLESFVST FSFQGLRLDE ALRLYLEAFR LPGEAPVIQR
800
801
LLEAFTERWM NCNGSPFANS DACFSLAYAV IMLNTDQHNH NVRKQNAPMT
850
851
LEEFRKNLKG VNGGKDFEQD ILEDMYHAIK NEEIVMPEEQ TGLVRENYVW
900
901
NVLLHRGATP EGIFLRVPTA SYDLDLFTMT WGPTIAALSY VFDKSLEETI
950
951
IQKAISGFRK CAMISAHYGL SDVFDNLIIS LCKFTALSSE SIENLPSVFG
1000
1001
SNPKAHIAAK TVFHLAHRHG DILREGWKNI MEAMLQLFRA QLLPKAMIEV
1050
1051
EDFVDPNGKI SLQREETPSN RGESTVLSFV SWLTLSGPEQ SSVRGPSTEN
1100
1101
QEAKRVALEC IKQCDPEKMI TESKFLQLES LQELMKALVS VTPDEETYDE
1150
1151
EDAAFCLEML LRIVLENRDR VGCVWQTVRD HLYHLCVQAQ DFCFLVERAV
1200
1201
VGLLRLAIRL LRREEISAQV LLSLRILLLM KPSVLSRVSH QVAYGLHELL
1250
1251
KTNAANIHSG DDWATLFTLL ECIGSGVKPP AALQATARAD APDAGAQSDS
1300
1301
ELPSYHQNDV SLDRGYTSDS EVYTDHGRPG KIHRSATDAD VVNSGWLVVG
1350
1351
KDDVDNSKPG PSRPGPSPLI NQYSLTVGLD LGPHDTKSLL KCVESLSFIV
1400
1401
RDAAHITPDN FELCVKTLRI FVEASLNGGC KSQEKRGKSH KYDSKGNRFK
1450
1451
KKSKEGSMLR RPRTSSQHAS RGGQSDDDED EGVPASYHTV SLQVSQDLLD
1500
1501
LMHTLHTRAA SIYSSWAEEQ RHLETGGQKI EADSRTLWAH CWCPLLQGIA
1550
1551
CLCCDARRQV RMQALTYLQR ALLVHDLQKL DALEWESCFN KVLFPLLTKL
1600
1601
LENISPADVG GMEETRMRAS TLLSKVFLQH LSPLLSLSTF AALWLTILDF
1650
1651
MDKYMHAGSS DLLSEAIPES LKNMLLVMDT AEIFHSADAR GGGPSALWEI
1700
1701
TWERIDCFLP HLRDELFKQT VIQDPMPMEP QGQKPLASAH LTSAAGDTRT
1750
1751
PGHPPPPEIP SELGACDFEK PESPRAASSS SPGSPVASSP SRLSPTPDGP
1800
1801
PPLAQPPLIL QPLASPLQVG VPPMTLPIIL NPALIEATSP VPLLATPRPT
1850
1851
DPIPTSEVN                                             
1859
 

Show the unformatted sequence.

Checksums:
CRC64:5015D2BD70009CFA
MD5:7d94a56df2f6a5bbd2939a786fd70f17

TreeFam

Below is a phylogenetic tree of animal genes, with ortholog and paralog assignments, from TreeFam.

AlphaFold Structure Prediction

The protein structure below has been predicted by DeepMind with AlphaFold. For more information, please visit the AlphaFold page for this protein.

Model confidence scale

  Very High (pLDDT > 90)
  Confident (90 > pLDDT > 70)
  Low (70 > pLDDT > 50)
  Very Low (pLDDT < 50)
Highly accurate protein structure prediction with AlphaFold. John Jumper, Richard Evans, Alexander Pritzel, Tim Green, Michael Figurnov, Olaf Ronneberger, Kathryn Tunyasuvunakool, Russ Bates, Augustin Žídek, Anna Potapenko, Alex Bridgland, Clemens Meyer, Simon A. A. Kohl, Andrew J. Ballard, Andrew Cowie, Bernardino Romera-Paredes, Stanislav Nikolov, Rishub Jain, Jonas Adler, Trevor Back, Stig Petersen, David Reiman, Ellen Clancy, Michal Zielinski, Martin Steinegger, Michalina Pacholska, Tamas Berghammer, Sebastian Bodenstein, David Silver, Oriol Vinyals, Andrew W. Senior, Koray Kavukcuoglu, Pushmeet Kohli & Demis Hassabis Nature 2021-07-15; DOI: 10.1038/s41586-021-03819-2;