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3  structures 1  species 0  interactions 1  sequence 1  architecture

Protein: LPAR1_HUMAN (Q92633)

Summary

This is the summary of UniProt entry LPAR1_HUMAN (Q92633).

Description: Lysophosphatidic acid receptor 1
Source organism: Homo sapiens (Human) (NCBI taxonomy ID 9606)
Length: 364 amino acids
Reference Proteome: ✓

Please note: when we start each new Pfam data release, we take a copy of the UniProt sequence database. This snapshot of UniProt forms the basis of the overview that you see here. It is important to note that, although some UniProt entries may be removed after a Pfam release, these entries will not be removed from Pfam until the next Pfam data release.

Pfam domains

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Source Domain Start End
transmembrane n/a 51 77
Pfam 7tm_1 66 311
transmembrane n/a 84 105
transmembrane n/a 125 144
transmembrane n/a 164 186
low_complexity n/a 164 171
transmembrane n/a 206 232
disorder n/a 242 244
transmembrane n/a 253 280
disorder n/a 336 342

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Sequence information

This is the amino acid sequence of the UniProt sequence database entry with the accession Q92633. This sequence is stored in the Pfam database and updated with each new Pfam release, but this means that the sequence we store may differ from that stored by UniProt.

Sequence:
1
MAAISTSIPV ISQPQFTAMN EPQCFYNESI AFFYNRSGKH LATEWNTVSK
50
51
LVMGLGITVC IFIMLANLLV MVAIYVNRRF HFPIYYLMAN LAAADFFAGL
100
101
AYFYLMFNTG PNTRRLTVST WLLRQGLIDT SLTASVANLL AIAIERHITV
150
151
FRMQLHTRMS NRRVVVVIVV IWTMAIVMGA IPSVGWNCIC DIENCSNMAP
200
201
LYSDSYLVFW AIFNLVTFVV MVVLYAHIFG YVRQRTMRMS RHSSGPRRNR
250
251
DTMMSLLKTV VIVLGAFIIC WTPGLVLLLL DVCCPQCDVL AYEKFFLLLA
300
301
EFNSAMNPII YSYRDKEMSA TFRQILCCQR SENPTGPTEG SDRSASSLNH
350
351
TILAGVHSND HSVV                                       
364
 

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Checksums:
CRC64:4CA6262FD00DFE74
MD5:e049776b0adb15bd1f2ab77d81cb7a0d

Structures

For those sequences which have a structure in the Protein DataBank, we use the mapping between UniProt, PDB and Pfam coordinate systems from the PDBe SIFTS project, to allow us to map Pfam domains onto UniProt three-dimensional structures. The table below shows the mapping between Pfam domains, this UniProt entry and a corresponding three dimensional structure.

Pfam family UniProt residues PDB ID PDB chain ID PDB residues View
7tm_1 66 - 311 4Z34 A 66 - 311 NGL View in InterPro
4Z35 A 66 - 311 NGL View in InterPro
4Z36 A 66 - 311 NGL View in InterPro
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The parts of the structure corresponding to the Pfam family are highlighted in yellow.

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TreeFam

Below is a phylogenetic tree of animal genes, with ortholog and paralog assignments, from TreeFam.