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2  structures 1  species 0  interactions 1  sequence 1  architecture

Protein: SEM4D_HUMAN (Q92854)

Summary

This is the summary of UniProt entry SEM4D_HUMAN (Q92854).

Description: Semaphorin-4D
Source organism: Homo sapiens (Human) (NCBI taxonomy ID 9606)
Length: 862 amino acids
Reference Proteome: ✓

Please note: when we start each new Pfam data release, we take a copy of the UniProt sequence database. This snapshot of UniProt forms the basis of the overview that you see here. It is important to note that, although some UniProt entries may be removed after a Pfam release, these entries will not be removed from Pfam until the next Pfam data release.

Pfam domains

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Source Domain Start End
sig_p n/a 1 23
Pfam Sema 52 480
low_complexity n/a 93 104
disorder n/a 354 359
disorder n/a 405 406
Pfam PSI 502 554
Pfam ig 561 639
low_complexity n/a 638 649
low_complexity n/a 646 654
disorder n/a 687 695
disorder n/a 698 700
transmembrane n/a 735 756
low_complexity n/a 735 752
disorder n/a 794 829
disorder n/a 833 837
disorder n/a 861 862

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Sequence information

This is the amino acid sequence of the UniProt sequence database entry with the accession Q92854. This sequence is stored in the Pfam database and updated with each new Pfam release, but this means that the sequence we store may differ from that stored by UniProt.

Sequence:
1
MRMCTPIRGL LMALAVMFGT AMAFAPIPRI TWEHREVHLV QFHEPDIYNY
50
51
SALLLSEDKD TLYIGAREAV FAVNALNISE KQHEVYWKVS EDKKAKCAEK
100
101
GKSKQTECLN YIRVLQPLSA TSLYVCGTNA FQPACDHLNL TSFKFLGKNE
150
151
DGKGRCPFDP AHSYTSVMVD GELYSGTSYN FLGSEPIISR NSSHSPLRTE
200
201
YAIPWLNEPS FVFADVIRKS PDSPDGEDDR VYFFFTEVSV EYEFVFRVLI
250
251
PRIARVCKGD QGGLRTLQKK WTSFLKARLI CSRPDSGLVF NVLRDVFVLR
300
301
SPGLKVPVFY ALFTPQLNNV GLSAVCAYNL STAEEVFSHG KYMQSTTVEQ
350
351
SHTKWVRYNG PVPKPRPGAC IDSEARAANY TSSLNLPDKT LQFVKDHPLM
400
401
DDSVTPIDNR PRLIKKDVNY TQIVVDRTQA LDGTVYDVMF VSTDRGALHK
450
451
AISLEHAVHI IEETQLFQDF EPVQTLLLSS KKGNRFVYAG SNSGVVQAPL
500
501
AFCGKHGTCE DCVLARDPYC AWSPPTATCV ALHQTESPSR GLIQEMSGDA
550
551
SVCPDKSKGS YRQHFFKHGG TAELKCSQKS NLARVFWKFQ NGVLKAESPK
600
601
YGLMGRKNLL IFNLSEGDSG VYQCLSEERV KNKTVFQVVA KHVLEVKVVP
650
651
KPVVAPTLSV VQTEGSRIAT KVLVASTQGS SPPTPAVQAT SSGAITLPPK
700
701
PAPTGTSCEP KIVINTVPQL HSEKTMYLKS SDNRLLMSLF LFFFVLFLCL
750
751
FFYNCYKGYL PRQCLKFRSA LLIGKKKPKS DFCDREQSLK ETLVEPGSFS
800
801
QQNGEHPKPA LDTGYETEQD TITSKVPTDR EDSQRIDDLS ARDKPFDVKC
850
851
ELKFADSDAD GD                                         
862
 

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Checksums:
CRC64:7B18EFEA98789371
MD5:5a090bea58616afc837a6064c3e6b34f

Structures

For those sequences which have a structure in the Protein DataBank, we use the mapping between UniProt, PDB and Pfam coordinate systems from the PDBe SIFTS project, to allow us to map Pfam domains onto UniProt three-dimensional structures. The table below shows the mapping between Pfam domains, this UniProt entry and a corresponding three dimensional structure.

Pfam family UniProt residues PDB ID PDB chain ID PDB residues View
ig 561 - 639 1OLZ A 540 - 618 Show 3D Structure View in InterPro
B 540 - 618 Show 3D Structure View in InterPro
3OL2 A 561 - 639 Show 3D Structure View in InterPro
PSI 502 - 554 1OLZ A 481 - 533 Show 3D Structure View in InterPro
B 481 - 533 Show 3D Structure View in InterPro
3OL2 A 502 - 554 Show 3D Structure View in InterPro
Sema 52 - 480 1OLZ A 31 - 459 Show 3D Structure View in InterPro
B 31 - 459 Show 3D Structure View in InterPro
3OL2 A 52 - 480 Show 3D Structure View in InterPro
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The parts of the structure corresponding to the Pfam family are highlighted in blue.

Loading Structure Data

TreeFam

Below is a phylogenetic tree of animal genes, with ortholog and paralog assignments, from TreeFam.

AlphaFold Structure Prediction

The protein structure below has been predicted by DeepMind with AlphaFold. For more information, please visit the AlphaFold page for this protein.

Model confidence scale

  Very High (pLDDT > 90)
  Confident (90 > pLDDT > 70)
  Low (70 > pLDDT > 50)
  Very Low (pLDDT < 50)
Highly accurate protein structure prediction with AlphaFold. John Jumper, Richard Evans, Alexander Pritzel, Tim Green, Michael Figurnov, Olaf Ronneberger, Kathryn Tunyasuvunakool, Russ Bates, Augustin Žídek, Anna Potapenko, Alex Bridgland, Clemens Meyer, Simon A. A. Kohl, Andrew J. Ballard, Andrew Cowie, Bernardino Romera-Paredes, Stanislav Nikolov, Rishub Jain, Jonas Adler, Trevor Back, Stig Petersen, David Reiman, Ellen Clancy, Michal Zielinski, Martin Steinegger, Michalina Pacholska, Tamas Berghammer, Sebastian Bodenstein, David Silver, Oriol Vinyals, Andrew W. Senior, Koray Kavukcuoglu, Pushmeet Kohli & Demis Hassabis Nature 2021-07-15; DOI: 10.1038/s41586-021-03819-2;