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1  structure 1  species 0  interactions 1  sequence 1  architecture

Protein: RAD50_HUMAN (Q92878)

Summary

This is the summary of UniProt entry RAD50_HUMAN (Q92878).

Description: DNA repair protein RAD50 EC=3.6.-.-
Source organism: Homo sapiens (Human) (NCBI taxonomy ID 9606)
Length: 1312 amino acids
Reference Proteome: ✓

Please note: when we start each new Pfam data release, we take a copy of the UniProt sequence database. This snapshot of UniProt forms the basis of the overview that you see here. It is important to note that, although some UniProt entries may be removed after a Pfam release, these entries will not be removed from Pfam until the next Pfam data release.

Pfam domains

Download the data used to generate the domain graphic in JSON format.

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Source Domain Start End
Pfam AAA_23 6 235
disorder n/a 64 66
disorder n/a 68 69
coiled_coil n/a 241 261
coiled_coil n/a 265 299
disorder n/a 275 296
disorder n/a 300 313
disorder n/a 315 320
coiled_coil n/a 315 349
disorder n/a 333 334
disorder n/a 350 352
disorder n/a 357 360
disorder n/a 399 402
coiled_coil n/a 401 421
disorder n/a 404 417
disorder n/a 419 420
disorder n/a 425 427
disorder n/a 429 430
coiled_coil n/a 450 531
disorder n/a 461 462
disorder n/a 485 490
disorder n/a 492 495
disorder n/a 499 502
disorder n/a 515 555
coiled_coil n/a 538 558
disorder n/a 580 582
coiled_coil n/a 580 628
disorder n/a 590 618
coiled_coil n/a 635 662
disorder n/a 644 646
Pfam Rad50_zn_hook 659 712
low_complexity n/a 709 727
disorder n/a 712 713
coiled_coil n/a 712 732
disorder n/a 716 720
disorder n/a 723 727
coiled_coil n/a 740 774
disorder n/a 761 762
disorder n/a 772 776
coiled_coil n/a 795 815
low_complexity n/a 824 835
coiled_coil n/a 825 845
disorder n/a 826 841
coiled_coil n/a 853 950
disorder n/a 857 859
disorder n/a 862 865
disorder n/a 867 869
disorder n/a 871 878
disorder n/a 888 889
disorder n/a 913 918
disorder n/a 923 928
disorder n/a 930 945
disorder n/a 965 972
coiled_coil n/a 973 1007
disorder n/a 975 978
disorder n/a 983 985
disorder n/a 995 1005
coiled_coil n/a 1024 1077
low_complexity n/a 1024 1038
disorder n/a 1028 1039
disorder n/a 1042 1055
disorder n/a 1059 1068
disorder n/a 1071 1073
Pfam SbcCD_C 1174 1251

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Sequence information

This is the amino acid sequence of the UniProt sequence database entry with the accession Q92878. This sequence is stored in the Pfam database and updated with each new Pfam release, but this means that the sequence we store may differ from that stored by UniProt.

Sequence:
1
MSRIEKMSIL GVRSFGIEDK DKQIITFFSP LTILVGPNGA GKTTIIECLK
50
51
YICTGDFPPG TKGNTFVHDP KVAQETDVRA QIRLQFRDVN GELIAVQRSM
100
101
VCTQKSKKTE FKTLEGVITR TKHGEKVSLS SKCAEIDREM ISSLGVSKAV
150
151
LNNVIFCHQE DSNWPLSEGK ALKQKFDEIF SATRYIKALE TLRQVRQTQG
200
201
QKVKEYQMEL KYLKQYKEKA CEIRDQITSK EAQLTSSKEI VKSYENELDP
250
251
LKNRLKEIEH NLSKIMKLDN EIKALDSRKK QMEKDNSELE EKMEKVFQGT
300
301
DEQLNDLYHN HQRTVREKER KLVDCHRELE KLNKESRLLN QEKSELLVEQ
350
351
GRLQLQADRH QEHIRARDSL IQSLATQLEL DGFERGPFSE RQIKNFHKLV
400
401
RERQEGEAKT ANQLMNDFAE KETLKQKQID EIRDKKTGLG RIIELKSEIL
450
451
SKKQNELKNV KYELQQLEGS SDRILELDQE LIKAERELSK AEKNSNVETL
500
501
KMEVISLQNE KADLDRTLRK LDQEMEQLNH HTTTRTQMEM LTKDKADKDE
550
551
QIRKIKSRHS DELTSLLGYF PNKKQLEDWL HSKSKEINQT RDRLAKLNKE
600
601
LASSEQNKNH INNELKRKEE QLSSYEDKLF DVCGSQDFES DLDRLKEEIE
650
651
KSSKQRAMLA GATAVYSQFI TQLTDENQSC CPVCQRVFQT EAELQEVISD
700
701
LQSKLRLAPD KLKSTESELK KKEKRRDEML GLVPMRQSII DLKEKEIPEL
750
751
RNKLQNVNRD IQRLKNDIEE QETLLGTIMP EEESAKVCLT DVTIMERFQM
800
801
ELKDVERKIA QQAAKLQGID LDRTVQQVNQ EKQEKQHKLD TVSSKIELNR
850
851
KLIQDQQEQI QHLKSTTNEL KSEKLQISTN LQRRQQLEEQ TVELSTEVQS
900
901
LYREIKDAKE QVSPLETTLE KFQQEKEELI NKKNTSNKIA QDKLNDIKEK
950
951
VKNIHGYMKD IENYIQDGKD DYKKQKETEL NKVIAQLSEC EKHKEKINED
1000
1001
MRLMRQDIDT QKIQERWLQD NLTLRKRNEE LKEVEEERKQ HLKEMGQMQV
1050
1051
LQMKSEHQKL EENIDNIKRN HNLALGRQKG YEEEIIHFKK ELREPQFRDA
1100
1101
EEKYREMMIV MRTTELVNKD LDIYYKTLDQ AIMKFHSMKM EEINKIIRDL
1150
1151
WRSTYRGQDI EYIEIRSDAD ENVSASDKRR NYNYRVVMLK GDTALDMRGR
1200
1201
CSAGQKVLAS LIIRLALAET FCLNCGIIAL DEPTTNLDRE NIESLAHALV
1250
1251
EIIKSRSQQR NFQLLVITHD EDFVELLGRS EYVEKFYRIK KNIDQCSEIV
1300
1301
KCSVSSLGFN VH                                         
1312
 

Show the unformatted sequence.

Checksums:
CRC64:1F208C3817FC41FC
MD5:1696279612fc59b0f56ccde5817552b6

Structures

For those sequences which have a structure in the Protein DataBank, we use the mapping between UniProt, PDB and Pfam coordinate systems from the PDBe SIFTS project, to allow us to map Pfam domains onto UniProt three-dimensional structures. The table below shows the mapping between Pfam domains, this UniProt entry and a corresponding three dimensional structure.

Pfam family UniProt residues PDB ID PDB chain ID PDB residues View
Rad50_zn_hook 659 - 712 5GOX A 659 - 712 Jmol OpenAstexViewer
B 659 - 712 Jmol OpenAstexViewer

TreeFam

Below is a phylogenetic tree of animal genes, with ortholog and paralog assignments, from TreeFam.