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0  structures 1  species 0  interactions 1  sequence 1  architecture

Protein: KCNN1_HUMAN (Q92952)

Summary

This is the summary of UniProt entry KCNN1_HUMAN (Q92952).

Description: Small conductance calcium-activated potassium channel protein 1
Source organism: Homo sapiens (Human) (NCBI taxonomy ID 9606)
Length: 543 amino acids
Reference Proteome: ✓

Please note: when we start each new Pfam data release, we take a copy of the UniProt sequence database. This snapshot of UniProt forms the basis of the overview that you see here. It is important to note that, although some UniProt entries may be removed after a Pfam release, these entries will not be removed from Pfam until the next Pfam data release.

Pfam domains

Download the data used to generate the domain graphic in JSON format.

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Source Domain Start End
disorder n/a 1 94
low_complexity n/a 49 82
Pfam SK_channel 92 208
transmembrane n/a 106 125
transmembrane n/a 137 160
low_complexity n/a 236 247
Pfam Ion_trans_2 275 370
transmembrane n/a 277 297
transmembrane n/a 317 334
transmembrane n/a 346 366
Pfam CaMBD 384 461
disorder n/a 424 425
disorder n/a 450 453
coiled_coil n/a 468 495
disorder n/a 479 480
disorder n/a 501 541
low_complexity n/a 502 523

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Sequence information

This is the amino acid sequence of the UniProt sequence database entry with the accession Q92952. This sequence is stored in the Pfam database and updated with each new Pfam release, but this means that the sequence we store may differ from that stored by UniProt.

Sequence:
1
MNSHSYNGSV GRPLGSGPGA LGRDPPDPEA GHPPQPPHSP GLQVVVAKSE
50
51
PARPSPGSPR GQPQDQDDDE DDEEDEAGRQ RASGKPSNVG HRLGHRRALF
100
101
EKRKRLSDYA LIFGMFGIVV MVTETELSWG VYTKESLYSF ALKCLISLST
150
151
AILLGLVVLY HAREIQLFMV DNGADDWRIA MTCERVFLIS LELAVCAIHP
200
201
VPGHYRFTWT ARLAFTYAPS VAEADVDVLL SIPMFLRLYL LGRVMLLHSK
250
251
IFTDASSRSI GALNKITFNT RFVMKTLMTI CPGTVLLVFS ISSWIIAAWT
300
301
VRVCERYHDK QEVTSNFLGA MWLISITFLS IGYGDMVPHT YCGKGVCLLT
350
351
GIMGAGCTAL VVAVVARKLE LTKAEKHVHN FMMDTQLTKR VKNAAANVLR
400
401
ETWLIYKHTR LVKKPDQARV RKHQRKFLQA IHQAQKLRSV KIEQGKLNDQ
450
451
ANTLTDLAKT QTVMYDLVSE LHAQHEELEA RLATLESRLD ALGASLQALP
500
501
GLIAQAIRPP PPPLPPRPGP GPQDQAARSS PCRWTPVAPS DCG       
543
 

Show the unformatted sequence.

Checksums:
CRC64:13EFF47C263BCB11
MD5:1c6eb53089930d08f99aa55b2e2e509a

TreeFam

Below is a phylogenetic tree of animal genes, with ortholog and paralog assignments, from TreeFam.

AlphaFold Structure Prediction

The protein structure below has been predicted by DeepMind with AlphaFold. For more information, please visit the AlphaFold page for this protein.

Model confidence scale

  Very High (pLDDT > 90)
  Confident (90 > pLDDT > 70)
  Low (70 > pLDDT > 50)
  Very Low (pLDDT < 50)
Highly accurate protein structure prediction with AlphaFold. John Jumper, Richard Evans, Alexander Pritzel, Tim Green, Michael Figurnov, Olaf Ronneberger, Kathryn Tunyasuvunakool, Russ Bates, Augustin Žídek, Anna Potapenko, Alex Bridgland, Clemens Meyer, Simon A. A. Kohl, Andrew J. Ballard, Andrew Cowie, Bernardino Romera-Paredes, Stanislav Nikolov, Rishub Jain, Jonas Adler, Trevor Back, Stig Petersen, David Reiman, Ellen Clancy, Michal Zielinski, Martin Steinegger, Michalina Pacholska, Tamas Berghammer, Sebastian Bodenstein, David Silver, Oriol Vinyals, Andrew W. Senior, Koray Kavukcuoglu, Pushmeet Kohli & Demis Hassabis Nature 2021-07-15; DOI: 10.1038/s41586-021-03819-2;