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5  structures 1  species 0  interactions 1  sequence 1  architecture

Protein: FBXW7_HUMAN (Q969H0)

Summary

This is the summary of UniProt entry FBXW7_HUMAN (Q969H0).

Description: F-box/WD repeat-containing protein 7 {ECO:0000305}
Source organism: Homo sapiens (Human) (NCBI taxonomy ID 9606)
Length: 707 amino acids
Reference Proteome: ✓

Please note: when we start each new Pfam data release, we take a copy of the UniProt sequence database. This snapshot of UniProt forms the basis of the overview that you see here. It is important to note that, although some UniProt entries may be removed after a Pfam release, these entries will not be removed from Pfam until the next Pfam data release.

Pfam domains

Download the data used to generate the domain graphic in JSON format.

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Source Domain Start End
disorder n/a 1 170
coiled_coil n/a 28 48
low_complexity n/a 30 51
low_complexity n/a 57 68
low_complexity n/a 88 136
coiled_coil n/a 97 124
low_complexity n/a 137 148
disorder n/a 172 178
disorder n/a 195 197
disorder n/a 204 228
low_complexity n/a 217 224
Pfam F-box-like 281 327
Pfam WD40 370 407
Pfam WD40 411 447
Pfam WD40 451 487
Pfam WD40 491 527
Pfam WD40 531 567
Pfam WD40 571 607
Pfam WD40 611 650

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Sequence information

This is the amino acid sequence of the UniProt sequence database entry with the accession Q969H0. This sequence is stored in the Pfam database and updated with each new Pfam release, but this means that the sequence we store may differ from that stored by UniProt.

Sequence:
1
MNQELLSVGS KRRRTGGSLR GNPSSSQVDE EQMNRVVEEE QQQQLRQQEE
50
51
EHTARNGEVV GVEPRPGGQN DSQQGQLEEN NNRFISVDED SSGNQEEQEE
100
101
DEEHAGEQDE EDEEEEEMDQ ESDDFDQSDD SSREDEHTHT NSVTNSSSIV
150
151
DLPVHQLSSP FYTKTTKMKR KLDHGSEVRS FSLGKKPCKV SEYTSTTGLV
200
201
PCSATPTTFG DLRAANGQGQ QRRRITSVQP PTGLQEWLKM FQSWSGPEKL
250
251
LALDELIDSC EPTQVKHMMQ VIEPQFQRDF ISLLPKELAL YVLSFLEPKD
300
301
LLQAAQTCRY WRILAEDNLL WREKCKEEGI DEPLHIKRRK VIKPGFIHSP
350
351
WKSAYIRQHR IDTNWRRGEL KSPKVLKGHD DHVITCLQFC GNRIVSGSDD
400
401
NTLKVWSAVT GKCLRTLVGH TGGVWSSQMR DNIIISGSTD RTLKVWNAET
450
451
GECIHTLYGH TSTVRCMHLH EKRVVSGSRD ATLRVWDIET GQCLHVLMGH
500
501
VAAVRCVQYD GRRVVSGAYD FMVKVWDPET ETCLHTLQGH TNRVYSLQFD
550
551
GIHVVSGSLD TSIRVWDVET GNCIHTLTGH QSLTSGMELK DNILVSGNAD
600
601
STVKIWDIKT GQCLQTLQGP NKHQSAVTCL QFNKNFVITS SDDGTVKLWD
650
651
LKTGEFIRNL VTLESGGSGG VVWRIRASNT KLVCAVGSRN GTEETKLLVL
700
701
DFDVDMK                                               
707
 

Show the unformatted sequence.

Checksums:
CRC64:E4A357F76DFD8203
MD5:1b21723ef8bdeb22696a36b89b79037b

Structures

For those sequences which have a structure in the Protein DataBank, we use the mapping between UniProt, PDB and Pfam coordinate systems from the PDBe SIFTS project, to allow us to map Pfam domains onto UniProt three-dimensional structures. The table below shows the mapping between Pfam domains, this UniProt entry and a corresponding three dimensional structure.

Pfam family UniProt residues PDB ID PDB chain ID PDB residues View
F-box-like 281 - 322 5IBK B 281 - 322 Show 3D Structure View in InterPro
E 281 - 322 Show 3D Structure View in InterPro
281 - 327 2OVP B 2281 - 2327 Show 3D Structure View in InterPro
2OVQ B 2281 - 2327 Show 3D Structure View in InterPro
2OVR B 2281 - 2327 Show 3D Structure View in InterPro
5V4B B 2281 - 2327 Show 3D Structure View in InterPro
WD40 370 - 407 2OVP B 2370 - 2407 Show 3D Structure View in InterPro
2OVQ B 2370 - 2407 Show 3D Structure View in InterPro
2OVR B 2370 - 2407 Show 3D Structure View in InterPro
5V4B B 2370 - 2407 Show 3D Structure View in InterPro
411 - 447 2OVP B 2411 - 2447 Show 3D Structure View in InterPro
2OVQ B 2411 - 2447 Show 3D Structure View in InterPro
2OVR B 2411 - 2447 Show 3D Structure View in InterPro
5V4B B 2411 - 2447 Show 3D Structure View in InterPro
451 - 487 2OVP B 2451 - 2487 Show 3D Structure View in InterPro
2OVQ B 2451 - 2487 Show 3D Structure View in InterPro
2OVR B 2451 - 2487 Show 3D Structure View in InterPro
5V4B B 2451 - 2487 Show 3D Structure View in InterPro
491 - 527 2OVP B 2491 - 2527 Show 3D Structure View in InterPro
2OVQ B 2491 - 2527 Show 3D Structure View in InterPro
2OVR B 2491 - 2527 Show 3D Structure View in InterPro
5V4B B 2491 - 2527 Show 3D Structure View in InterPro
531 - 567 2OVP B 2531 - 2567 Show 3D Structure View in InterPro
2OVQ B 2531 - 2567 Show 3D Structure View in InterPro
2OVR B 2531 - 2567 Show 3D Structure View in InterPro
5V4B B 2531 - 2567 Show 3D Structure View in InterPro
571 - 607 2OVP B 2571 - 2607 Show 3D Structure View in InterPro
2OVQ B 2571 - 2607 Show 3D Structure View in InterPro
2OVR B 2571 - 2607 Show 3D Structure View in InterPro
5V4B B 2571 - 2607 Show 3D Structure View in InterPro
611 - 650 2OVP B 2611 - 2650 Show 3D Structure View in InterPro
2OVQ B 2611 - 2650 Show 3D Structure View in InterPro
2OVR B 2611 - 2650 Show 3D Structure View in InterPro
5V4B B 2611 - 2650 Show 3D Structure View in InterPro
×

The parts of the structure corresponding to the Pfam family are highlighted in blue.

Loading Structure Data

TreeFam

Below is a phylogenetic tree of animal genes, with ortholog and paralog assignments, from TreeFam.

AlphaFold Structure Prediction

The protein structure below has been predicted by DeepMind with AlphaFold. For more information, please visit the AlphaFold page for this protein.

Model confidence scale

  Very High (pLDDT > 90)
  Confident (90 > pLDDT > 70)
  Low (70 > pLDDT > 50)
  Very Low (pLDDT < 50)
Highly accurate protein structure prediction with AlphaFold. John Jumper, Richard Evans, Alexander Pritzel, Tim Green, Michael Figurnov, Olaf Ronneberger, Kathryn Tunyasuvunakool, Russ Bates, Augustin Žídek, Anna Potapenko, Alex Bridgland, Clemens Meyer, Simon A. A. Kohl, Andrew J. Ballard, Andrew Cowie, Bernardino Romera-Paredes, Stanislav Nikolov, Rishub Jain, Jonas Adler, Trevor Back, Stig Petersen, David Reiman, Ellen Clancy, Michal Zielinski, Martin Steinegger, Michalina Pacholska, Tamas Berghammer, Sebastian Bodenstein, David Silver, Oriol Vinyals, Andrew W. Senior, Koray Kavukcuoglu, Pushmeet Kohli & Demis Hassabis Nature 2021-07-15; DOI: 10.1038/s41586-021-03819-2;