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1  structure 1  species 0  interactions 1  sequence 1  architecture

Protein: EXOS8_HUMAN (Q96B26)

Summary

This is the summary of UniProt entry EXOS8_HUMAN (Q96B26).

Description: Exosome complex component RRP43
Source organism: Homo sapiens (Human) (NCBI taxonomy ID 9606)
View Pfam proteome data.
Length: 276 amino acids
Reference Proteome: ✓

Please note: when we start each new Pfam data release, we take a copy of the UniProt sequence database. This snapshot of UniProt forms the basis of the overview that you see here. It is important to note that, although some UniProt entries may be removed after a Pfam release, these entries will not be removed from Pfam until the next Pfam data release.

Pfam domains

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Source Domain Start End
disorder n/a 29 30
Pfam RNase_PH 31 166
Pfam RNase_PH_C 191 258

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Sequence information

This is the amino acid sequence of the UniProt sequence database entry with the accession Q96B26. This sequence is stored in the Pfam database and updated with each new Pfam release, but this means that the sequence we store may differ from that stored by UniProt.

Sequence:
1
MAAGFKTVEP LEYYRRFLKE NCRPDGRELG EFRTTTVNIG SISTADGSAL
50
51
VKLGNTTVIC GVKAEFAAPS TDAPDKGYVV PNVDLPPLCS SRFRSGPPGE
100
101
EAQVASQFIA DVIENSQIIQ KEDLCISPGK LVWVLYCDLI CLDYDGNILD
150
151
ACTFALLAAL KNVQLPEVTI NEETALAEVN LKKKSYLNIR THPVATSFAV
200
201
FDDTLLIVDP TGEEEHLATG TLTIVMDEEG KLCCLHKPGG SGLTGAKLQD
250
251
CMSRAVTRHK EVKKLMDEVI KSMKPK                          
276
 

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Checksums:
CRC64:FC8F5BAE74A1FF55
MD5:8053c83e161ccad7f126c612ec404a6b

Structures

For those sequences which have a structure in the Protein DataBank, we use the mapping between UniProt, PDB and Pfam coordinate systems from the PDBe SIFTS project, to allow us to map Pfam domains onto UniProt three-dimensional structures. The table below shows the mapping between Pfam domains, this UniProt entry and a corresponding three dimensional structure.

Pfam family UniProt residues PDB ID PDB chain ID PDB residues View
RNase_PH 31 - 166 2NN6 C 31 - 166 Jmol OpenAstexViewer
RNase_PH_C 191 - 258 2NN6 C 191 - 258 Jmol OpenAstexViewer

TreeFam

Below is a phylogenetic tree of animal genes, with ortholog and paralog assignments, from TreeFam.