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3  structures 1  species 0  interactions 1  sequence 1  architecture

Protein: DHX58_HUMAN (Q96C10)

Summary

This is the summary of UniProt entry DHX58_HUMAN (Q96C10).

Description: Probable ATP-dependent RNA helicase DHX58 EC=3.6.4.13
Source organism: Homo sapiens (Human) (NCBI taxonomy ID 9606)
View Pfam proteome data.
Length: 678 amino acids
Reference Proteome: ✓

Please note: when we start each new Pfam data release, we take a copy of the UniProt sequence database. This snapshot of UniProt forms the basis of the overview that you see here. It is important to note that, although some UniProt entries may be removed after a Pfam release, these entries will not be removed from Pfam until the next Pfam data release.

Pfam domains

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Source Domain Start End
Pfam ResIII 1 172
low_complexity n/a 49 59
disorder n/a 165 166
Pfam RIG-I_C 215 343
disorder n/a 341 345
Pfam Helicase_C 349 475
low_complexity n/a 382 393
disorder n/a 409 412
disorder n/a 414 422
coiled_coil n/a 496 519
low_complexity n/a 524 539
low_complexity n/a 532 545
disorder n/a 541 542
Pfam RIG-I_C-RD 552 667
disorder n/a 574 575

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Sequence information

This is the amino acid sequence of the UniProt sequence database entry with the accession Q96C10. This sequence is stored in the Pfam database and updated with each new Pfam release, but this means that the sequence we store may differ from that stored by UniProt.

Sequence:
1
MELRSYQWEV IMPALEGKNI IIWLPTGAGK TRAAAYVAKR HLETVDGAKV
50
51
VVLVNRVHLV TQHGEEFRRM LDGRWTVTTL SGDMGPRAGF GHLARCHDLL
100
101
ICTAELLQMA LTSPEEEEHV ELTVFSLIVV DECHHTHKDT VYNVIMSQYL
150
151
ELKLQRAQPL PQVLGLTASP GTGGASKLDG AINHVLQLCA NLDTWCIMSP
200
201
QNCCPQLQEH SQQPCKQYNL CHRRSQDPFG DLLKKLMDQI HDHLEMPELS
250
251
RKFGTQMYEQ QVVKLSEAAA LAGLQEQRVY ALHLRRYNDA LLIHDTVRAV
300
301
DALAALQDFY HREHVTKTQI LCAERRLLAL FDDRKNELAH LATHGPENPK
350
351
LEMLEKILQR QFSSSNSPRG IIFTRTRQSA HSLLLWLQQQ QGLQTVDIRA
400
401
QLLIGAGNSS QSTHMTQRDQ QEVIQKFQDG TLNLLVATSV AEEGLDIPHC
450
451
NVVVRYGLLT NEISMVQARG RARADQSVYA FVATEGSREL KRELINEALE
500
501
TLMEQAVAAV QKMDQAEYQA KIRDLQQAAL TKRAAQAAQR ENQRQQFPVE
550
551
HVQLLCINCM VAVGHGSDLR KVEGTHHVNV NPNFSNYYNV SRDPVVINKV
600
601
FKDWKPGGVI SCRNCGEVWG LQMIYKSVKL PVLKVRSMLL ETPQGRIQAK
650
651
KWSRVPFSVP DFDFLQHCAE NLSDLSLD                        
678
 

Show the unformatted sequence.

Checksums:
CRC64:859E1749C7313D06
MD5:69937e623769c7b8bbd033de6d5ff8cc

Structures

For those sequences which have a structure in the Protein DataBank, we use the mapping between UniProt, PDB and Pfam coordinate systems from the PDBe SIFTS project, to allow us to map Pfam domains onto UniProt three-dimensional structures. The table below shows the mapping between Pfam domains, this UniProt entry and a corresponding three dimensional structure.

Pfam family UniProt residues PDB ID PDB chain ID PDB residues View
RIG-I_C-RD 552 - 667 2RQA A 552 - 667 Jmol OpenAstexViewer
2W4R A 552 - 667 Jmol OpenAstexViewer
B 552 - 667 Jmol OpenAstexViewer
C 552 - 667 Jmol OpenAstexViewer
D 552 - 667 Jmol OpenAstexViewer
3EQT A 552 - 667 Jmol OpenAstexViewer
B 552 - 667 Jmol OpenAstexViewer

TreeFam

Below is a phylogenetic tree of animal genes, with ortholog and paralog assignments, from TreeFam.