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2  structures 1  species 0  interactions 1  sequence 1  architecture

Protein: PGAM5_HUMAN (Q96HS1)

Summary

This is the summary of UniProt entry PGAM5_HUMAN (Q96HS1).

Description: Serine/threonine-protein phosphatase PGAM5, mitochondrial EC=3.1.3.16
Source organism: Homo sapiens (Human) (NCBI taxonomy ID 9606)
View Pfam proteome data.
Length: 289 amino acids
Reference Proteome: ✓

Please note: when we start each new Pfam data release, we take a copy of the UniProt sequence database. This snapshot of UniProt forms the basis of the overview that you see here. It is important to note that, although some UniProt entries may be removed after a Pfam release, these entries will not be removed from Pfam until the next Pfam data release.

Pfam domains

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Source Domain Start End
sig_p n/a 1 19
low_complexity n/a 5 19
disorder n/a 32 59
low_complexity n/a 32 55
disorder n/a 84 88
Pfam His_Phos_1 100 278
disorder n/a 114 123
disorder n/a 181 182
disorder n/a 185 186
disorder n/a 286 288

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Sequence information

This is the amino acid sequence of the UniProt sequence database entry with the accession Q96HS1. This sequence is stored in the Pfam database and updated with each new Pfam release, but this means that the sequence we store may differ from that stored by UniProt.

Sequence:
1
MAFRQALQLA ACGLAGGSAA VLFSAVAVGK PRAGGDAEPR PAEPPAWAGG
50
51
ARPGPGVWDP NWDRREPLSL INVRKRNVES GEEELASKLD HYKAKATRHI
100
101
FLIRHSQYHV DGSLEKDRTL TPLGREQAEL TGLRLASLGL KFNKIVHSSM
150
151
TRAIETTDII SRHLPGVCKV STDLLREGAP IEPDPPVSHW KPEAVQYYED
200
201
GARIEAAFRN YIHRADARQE EDSYEIFICH ANVIRYIVCR ALQFPPEGWL
250
251
RLSLNNGSIT HLVIRPNGRV ALRTLGDTGF MPPDKITRS            
289
 

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Checksums:
CRC64:EE20D2F0A99FCD83
MD5:8188ad774ba0ea6dd245c2528d098323

Structures

For those sequences which have a structure in the Protein DataBank, we use the mapping between UniProt, PDB and Pfam coordinate systems from the PDBe SIFTS project, to allow us to map Pfam domains onto UniProt three-dimensional structures. The table below shows the mapping between Pfam domains, this UniProt entry and a corresponding three dimensional structure.

Pfam family UniProt residues PDB ID PDB chain ID PDB residues View
His_Phos_1 100 - 278 3MXO A 100 - 278 Jmol OpenAstexViewer
B 100 - 278 Jmol OpenAstexViewer
3O0T A 100 - 278 Jmol OpenAstexViewer
B 100 - 278 Jmol OpenAstexViewer

TreeFam

Below is a phylogenetic tree of animal genes, with ortholog and paralog assignments, from TreeFam.