Please note: this site relies heavily on the use of javascript. Without a javascript-enabled browser, this site will not function correctly. Please enable javascript and reload the page, or switch to a different browser.
2  structures 1  species 0  interactions 1  sequence 1  architecture

Protein: LRIG1_HUMAN (Q96JA1)

Summary

This is the summary of UniProt entry LRIG1_HUMAN (Q96JA1).

Description: Leucine-rich repeats and immunoglobulin-like domains protein 1
Source organism: Homo sapiens (Human) (NCBI taxonomy ID 9606)
Length: 1093 amino acids
Reference Proteome: ✓

Please note: when we start each new Pfam data release, we take a copy of the UniProt sequence database. This snapshot of UniProt forms the basis of the overview that you see here. It is important to note that, although some UniProt entries may be removed after a Pfam release, these entries will not be removed from Pfam until the next Pfam data release.

Pfam domains

Download the data used to generate the domain graphic in JSON format.

Show or hide the data used to generate the graphic in JSON format.

Source Domain Start End
sig_p n/a 1 33
low_complexity n/a 18 28
low_complexity n/a 32 49
Pfam LRR_8 70 104
Pfam LRR_8 140 189
low_complexity n/a 186 196
Pfam LRR_8 188 247
Pfam LRR_8 307 367
low_complexity n/a 322 342
Pfam LRR_8 382 442
low_complexity n/a 404 416
Pfam LRRCT 465 490
Pfam Ig_3 494 581
low_complexity n/a 517 524
Pfam I-set 599 689
disorder n/a 627 628
disorder n/a 630 638
disorder n/a 641 645
Pfam I-set 693 780
disorder n/a 727 729
disorder n/a 765 766
disorder n/a 780 781
transmembrane n/a 793 816
disorder n/a 825 880
disorder n/a 882 886
disorder n/a 907 928
disorder n/a 945 983
disorder n/a 991 992
disorder n/a 999 1093

Show or hide domain scores.

Sequence information

This is the amino acid sequence of the UniProt sequence database entry with the accession Q96JA1. This sequence is stored in the Pfam database and updated with each new Pfam release, but this means that the sequence we store may differ from that stored by UniProt.

Sequence:
1
MARPVRGGLG APRRSPCLLL LWLLLLRLEP VTAAAGPRAP CAAACTCAGD
50
51
SLDCGGRGLA ALPGDLPSWT RSLNLSYNKL SEIDPAGFED LPNLQEVYLN
100
101
NNELTAVPSL GAASSHVVSL FLQHNKIRSV EGSQLKAYLS LEVLDLSLNN
150
151
ITEVRNTCFP HGPPIKELNL AGNRIGTLEL GAFDGLSRSL LTLRLSKNRI
200
201
TQLPVRAFKL PRLTQLDLNR NRIRLIEGLT FQGLNSLEVL KLQRNNISKL
250
251
TDGAFWGLSK MHVLHLEYNS LVEVNSGSLY GLTALHQLHL SNNSIARIHR
300
301
KGWSFCQKLH ELVLSFNNLT RLDEESLAEL SSLSVLRLSH NSISHIAEGA
350
351
FKGLRSLRVL DLDHNEISGT IEDTSGAFSG LDSLSKLTLF GNKIKSVAKR
400
401
AFSGLEGLEH LNLGGNAIRS VQFDAFVKMK NLKELHISSD SFLCDCQLKW
450
451
LPPWLIGRML QAFVTATCAH PESLKGQSIF SVPPESFVCD DFLKPQIITQ
500
501
PETTMAMVGK DIRFTCSAAS SSSSPMTFAW KKDNEVLTNA DMENFVHVHA
550
551
QDGEVMEYTT ILHLRQVTFG HEGRYQCVIT NHFGSTYSHK ARLTVNVLPS
600
601
FTKTPHDITI RTTTMARLEC AATGHPNPQI AWQKDGGTDF PAARERRMHV
650
651
MPDDDVFFIT DVKIDDAGVY SCTAQNSAGS ISANATLTVL ETPSLVVPLE
700
701
DRVVSVGETV ALQCKATGNP PPRITWFKGD RPLSLTERHH LTPDNQLLVV
750
751
QNVVAEDAGR YTCEMSNTLG TERAHSQLSV LPAAGCRKDG TTVGIFTIAV
800
801
VSSIVLTSLV WVCIIYQTRK KSEEYSVTNT DETVVPPDVP SYLSSQGTLS
850
851
DRQETVVRTE GGPQANGHIE SNGVCPRDAS HFPEPDTHSV ACRQPKLCAG
900
901
SAYHKEPWKA MEKAEGTPGP HKMEHGGRVV CSDCNTEVDC YSRGQAFHPQ
950
951
PVSRDSAQPS APNGPEPGGS DQEHSPHHQC SRTAAGSCPE CQGSLYPSNH
1000
1001
DRMLTAVKKK PMASLDGKGD SSWTLARLYH PDSTELQPAS SLTSGSPERA
1050
1051
EAQYLLVSNG HLPKACDASP ESTPLTGQLP GKQRVPLLLA PKS       
1093
 

Show the unformatted sequence.

Checksums:
CRC64:7B4F13CA343AF943
MD5:00993a18899500a5952fd77826fa5419

Structures

For those sequences which have a structure in the Protein DataBank, we use the mapping between UniProt, PDB and Pfam coordinate systems from the PDBe SIFTS project, to allow us to map Pfam domains onto UniProt three-dimensional structures. The table below shows the mapping between Pfam domains, this UniProt entry and a corresponding three dimensional structure.

Pfam family UniProt residues PDB ID PDB chain ID PDB residues View
I-set 599 - 689 4U7M A 599 - 689 Show 3D Structure View in InterPro
693 - 780 4U7M A 693 - 780 Show 3D Structure View in InterPro
Ig_3 494 - 581 4U7M A 494 - 581 Show 3D Structure View in InterPro
LRR_8 140 - 189 4U7L A 100 - 149 Show 3D Structure View in InterPro
188 - 247 4U7L A 148 - 207 Show 3D Structure View in InterPro
307 - 367 4U7L A 267 - 327 Show 3D Structure View in InterPro
382 - 442 4U7L A 342 - 402 Show 3D Structure View in InterPro
70 - 104 4U7L A 30 - 64 Show 3D Structure View in InterPro
LRRCT 465 - 490 4U7L A 425 - 450 Show 3D Structure View in InterPro
×

The parts of the structure corresponding to the Pfam family are highlighted in blue.

Loading Structure Data

TreeFam

Below is a phylogenetic tree of animal genes, with ortholog and paralog assignments, from TreeFam.

AlphaFold Structure Prediction

The protein structure below has been predicted by DeepMind with AlphaFold. For more information, please visit the AlphaFold page for this protein.

Model confidence scale

  Very High (pLDDT > 90)
  Confident (90 > pLDDT > 70)
  Low (70 > pLDDT > 50)
  Very Low (pLDDT < 50)
Highly accurate protein structure prediction with AlphaFold. John Jumper, Richard Evans, Alexander Pritzel, Tim Green, Michael Figurnov, Olaf Ronneberger, Kathryn Tunyasuvunakool, Russ Bates, Augustin Žídek, Anna Potapenko, Alex Bridgland, Clemens Meyer, Simon A. A. Kohl, Andrew J. Ballard, Andrew Cowie, Bernardino Romera-Paredes, Stanislav Nikolov, Rishub Jain, Jonas Adler, Trevor Back, Stig Petersen, David Reiman, Ellen Clancy, Michal Zielinski, Martin Steinegger, Michalina Pacholska, Tamas Berghammer, Sebastian Bodenstein, David Silver, Oriol Vinyals, Andrew W. Senior, Koray Kavukcuoglu, Pushmeet Kohli & Demis Hassabis Nature 2021-07-15; DOI: 10.1038/s41586-021-03819-2;